High miR-449b expression in prostate cancer is associated with biochemical recurrence after radical prostatectomy
Prostate cancer is one of the leading causes of cancer death amongst men in economically advanced countries. The disease is characterized by a greatly varying clinical course, where some patients harbor non- or slowly-progressive disease, others highly aggressive disease. There is a great lack of ma...
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| Veröffentlicht in: | BMC cancer 2014-11, Vol.14 (1), p.859-859, Article 859 |
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| creator | Mortensen, Martin Mørck Høyer, Søren Orntoft, Torben Falck Sørensen, Karina Dalsgaard Dyrskjøt, Lars Borre, Michael |
| description | Prostate cancer is one of the leading causes of cancer death amongst men in economically advanced countries. The disease is characterized by a greatly varying clinical course, where some patients harbor non- or slowly-progressive disease, others highly aggressive disease. There is a great lack of markers to differentiate between aggressive and indolent disease. Markers that could help to identify patients needing curative treatment while sparing those who do not.
MicroRNA profiling of 672 microRNAs using multiplex RT-qPCR was performed using 36 prostate cancer samples to evaluate the association of microRNAs and biochemical recurrence after radical prostatectomy.
Among 31 microRNAs associated with recurrence, we identified miR-449b, which was further validated in an independent cohort of 163 radical prostatectomy patients. Patients expressing miR-449b had a significantly higher risk of recurrence (HR = 1.57; p = 0.028), and miR-449b was shown to be an independent predictor of recurrence after prostatectomy (HR = 1.9; p = 0.003) when modeled with known risk factors of recurrent disease in multivariate analysis.
High miR-449b expression was shown to be an independent predictor of biochemical recurrence after radical prostatectomy. |
| doi_str_mv | 10.1186/1471-2407-14-859 |
| format | Article |
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MicroRNA profiling of 672 microRNAs using multiplex RT-qPCR was performed using 36 prostate cancer samples to evaluate the association of microRNAs and biochemical recurrence after radical prostatectomy.
Among 31 microRNAs associated with recurrence, we identified miR-449b, which was further validated in an independent cohort of 163 radical prostatectomy patients. Patients expressing miR-449b had a significantly higher risk of recurrence (HR = 1.57; p = 0.028), and miR-449b was shown to be an independent predictor of recurrence after prostatectomy (HR = 1.9; p = 0.003) when modeled with known risk factors of recurrent disease in multivariate analysis.
High miR-449b expression was shown to be an independent predictor of biochemical recurrence after radical prostatectomy.</description><identifier>ISSN: 1471-2407</identifier><identifier>EISSN: 1471-2407</identifier><identifier>DOI: 10.1186/1471-2407-14-859</identifier><identifier>PMID: 25416653</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Aged ; Biomarkers ; Biopsy ; Cohort Studies ; Gene Expression ; Gene Expression Profiling ; Hospitals ; Humans ; Lasers ; Male ; MicroRNAs ; MicroRNAs - genetics ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Patients ; Prostate cancer ; Prostatectomy ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - mortality ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Recurrence ; Reproducibility of Results ; Surveillance ; Urology</subject><ispartof>BMC cancer, 2014-11, Vol.14 (1), p.859-859, Article 859</ispartof><rights>2014 Mortensen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Mortensen et al.; licensee BioMed Central Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b484t-2a5222ff3d992624c9b7afbb589103321cd36061df2055e6ce82978343aa39e3</citedby><cites>FETCH-LOGICAL-b484t-2a5222ff3d992624c9b7afbb589103321cd36061df2055e6ce82978343aa39e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247690/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247690/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25416653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mortensen, Martin Mørck</creatorcontrib><creatorcontrib>Høyer, Søren</creatorcontrib><creatorcontrib>Orntoft, Torben Falck</creatorcontrib><creatorcontrib>Sørensen, Karina Dalsgaard</creatorcontrib><creatorcontrib>Dyrskjøt, Lars</creatorcontrib><creatorcontrib>Borre, Michael</creatorcontrib><title>High miR-449b expression in prostate cancer is associated with biochemical recurrence after radical prostatectomy</title><title>BMC cancer</title><addtitle>BMC Cancer</addtitle><description>Prostate cancer is one of the leading causes of cancer death amongst men in economically advanced countries. The disease is characterized by a greatly varying clinical course, where some patients harbor non- or slowly-progressive disease, others highly aggressive disease. There is a great lack of markers to differentiate between aggressive and indolent disease. Markers that could help to identify patients needing curative treatment while sparing those who do not.
MicroRNA profiling of 672 microRNAs using multiplex RT-qPCR was performed using 36 prostate cancer samples to evaluate the association of microRNAs and biochemical recurrence after radical prostatectomy.
Among 31 microRNAs associated with recurrence, we identified miR-449b, which was further validated in an independent cohort of 163 radical prostatectomy patients. Patients expressing miR-449b had a significantly higher risk of recurrence (HR = 1.57; p = 0.028), and miR-449b was shown to be an independent predictor of recurrence after prostatectomy (HR = 1.9; p = 0.003) when modeled with known risk factors of recurrent disease in multivariate analysis.
High miR-449b expression was shown to be an independent predictor of biochemical recurrence after radical prostatectomy.</description><subject>Aged</subject><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Cohort Studies</subject><subject>Gene Expression</subject><subject>Gene Expression Profiling</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Lasers</subject><subject>Male</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Staging</subject><subject>Patients</subject><subject>Prostate cancer</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - mortality</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Recurrence</subject><subject>Reproducibility of Results</subject><subject>Surveillance</subject><subject>Urology</subject><issn>1471-2407</issn><issn>1471-2407</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1ks1r3DAQxUVpaD7ae05B0EsvTvRlWboEypJmAwuBkLuQ5fGugm1tJDtt_vtod5MlKe1Jw8xPj6enQeiUknNKlbygoqIFE6QqqChUqT-ho33r87v6EB2n9EAIrRRRX9AhKwWVsuRH6HHulyvc-7tCCF1j-LOOkJIPA_YDXseQRjsCdnZwELFP2KYUnM-9Bv_24wrXPrgV9N7ZDkdwU4yQUWzbMfPRNtvBm44bQ__8FR20tkvw7fU8Qfe_ru5n82Jxe30z-7koaqHEWDBbMsbaljdaM8mE03Vl27oulaaEc0ZdwyWRtGkZKUuQDhTTleKCW8s18BN0uZNdT3UPjYNhjLYz6-h7G59NsN58nAx-ZZbhyQgmKqlJFpjtBPIT_yPwceJCbzaJm03iuTL5Q7LKj1cbMTxOkEbT--Sg6-wAYUqGSqZKJjmVGf3-F_oQpjjkjLYU0VoTkSmyo1wONUVo944oMZul-JeHs_dR7C-8bQF_AWuqs9I</recordid><startdate>20141121</startdate><enddate>20141121</enddate><creator>Mortensen, Martin Mørck</creator><creator>Høyer, Søren</creator><creator>Orntoft, Torben Falck</creator><creator>Sørensen, Karina Dalsgaard</creator><creator>Dyrskjøt, Lars</creator><creator>Borre, Michael</creator><general>BioMed Central</general><general>BioMed Central Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141121</creationdate><title>High miR-449b expression in prostate cancer is associated with biochemical recurrence after radical prostatectomy</title><author>Mortensen, Martin Mørck ; Høyer, Søren ; Orntoft, Torben Falck ; Sørensen, Karina Dalsgaard ; Dyrskjøt, Lars ; Borre, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b484t-2a5222ff3d992624c9b7afbb589103321cd36061df2055e6ce82978343aa39e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Biomarkers</topic><topic>Biopsy</topic><topic>Cohort Studies</topic><topic>Gene Expression</topic><topic>Gene Expression Profiling</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Lasers</topic><topic>Male</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Staging</topic><topic>Patients</topic><topic>Prostate cancer</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - mortality</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Recurrence</topic><topic>Reproducibility of Results</topic><topic>Surveillance</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mortensen, Martin Mørck</creatorcontrib><creatorcontrib>Høyer, Søren</creatorcontrib><creatorcontrib>Orntoft, Torben Falck</creatorcontrib><creatorcontrib>Sørensen, Karina Dalsgaard</creatorcontrib><creatorcontrib>Dyrskjøt, Lars</creatorcontrib><creatorcontrib>Borre, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mortensen, Martin Mørck</au><au>Høyer, Søren</au><au>Orntoft, Torben Falck</au><au>Sørensen, Karina Dalsgaard</au><au>Dyrskjøt, Lars</au><au>Borre, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High miR-449b expression in prostate cancer is associated with biochemical recurrence after radical prostatectomy</atitle><jtitle>BMC cancer</jtitle><addtitle>BMC Cancer</addtitle><date>2014-11-21</date><risdate>2014</risdate><volume>14</volume><issue>1</issue><spage>859</spage><epage>859</epage><pages>859-859</pages><artnum>859</artnum><issn>1471-2407</issn><eissn>1471-2407</eissn><abstract>Prostate cancer is one of the leading causes of cancer death amongst men in economically advanced countries. The disease is characterized by a greatly varying clinical course, where some patients harbor non- or slowly-progressive disease, others highly aggressive disease. There is a great lack of markers to differentiate between aggressive and indolent disease. Markers that could help to identify patients needing curative treatment while sparing those who do not.
MicroRNA profiling of 672 microRNAs using multiplex RT-qPCR was performed using 36 prostate cancer samples to evaluate the association of microRNAs and biochemical recurrence after radical prostatectomy.
Among 31 microRNAs associated with recurrence, we identified miR-449b, which was further validated in an independent cohort of 163 radical prostatectomy patients. Patients expressing miR-449b had a significantly higher risk of recurrence (HR = 1.57; p = 0.028), and miR-449b was shown to be an independent predictor of recurrence after prostatectomy (HR = 1.9; p = 0.003) when modeled with known risk factors of recurrent disease in multivariate analysis.
High miR-449b expression was shown to be an independent predictor of biochemical recurrence after radical prostatectomy.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>25416653</pmid><doi>10.1186/1471-2407-14-859</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Aged Biomarkers Biopsy Cohort Studies Gene Expression Gene Expression Profiling Hospitals Humans Lasers Male MicroRNAs MicroRNAs - genetics Middle Aged Neoplasm Grading Neoplasm Staging Patients Prostate cancer Prostatectomy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Recurrence Reproducibility of Results Surveillance Urology |
| title | High miR-449b expression in prostate cancer is associated with biochemical recurrence after radical prostatectomy |
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