ArfA recognizes the lack of mRNA in the mRNA channel after RF2 binding for ribosome rescue

Although trans-translation mediated by tmRNA-SmpB has long been known as the sole system to relieve bacterial stalled ribosomes, ArfA has recently been identified as an alternative factor for ribosome rescue in Escherichia coli. This process requires hydrolysis of nascent peptidyl-tRNA by RF2, which...

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Veröffentlicht in:	Nucleic acids research 2014-12, Vol.42 (21), p.13339-13352
Hauptverfasser:	Kurita, Daisuke, Chadani, Yuhei, Muto, Akira, Abo, Tatsuhiko, Himeno, Hyouta
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cysteine - genetics Escherichia coli Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Models, Molecular Mutation Peptide Termination Factors - metabolism Protein Binding Ribosomes - chemistry Ribosomes - metabolism RNA RNA, Messenger - chemistry RNA, Messenger - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism
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