Evaluation of Hyperthermia of Magnetic Nanoparticles by Dehydrating DNA
A method based on the thermodynamic equilibrium reached between the hybridization and denaturation of double-stranded DNA (ds-DNA) is opened up to evaluate the hyperthermia performance of magnetic nanoparticles (MNPs). Two kinds of MNPs with different sizes and magnetic performance are chosen and th...
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| Veröffentlicht in: | Scientific reports 2014-11, Vol.4 (1), p.7216-7216, Article 7216 |
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| creator | Yu, Lina Liu, Jinming Wu, Kai Klein, Todd Jiang, Yong Wang, Jian-Ping |
| description | A method based on the thermodynamic equilibrium reached between the hybridization and denaturation of double-stranded DNA (ds-DNA) is opened up to evaluate the hyperthermia performance of magnetic nanoparticles (MNPs). Two kinds of MNPs with different sizes and magnetic performance are chosen and their temperature increments at the surface area under an alternating magnetic field (AMF) are calculated and compared through the concentration variation of ds-DNA modified on the surface. The temperature difference between the surface area of MNPs and bulk solution is also investigated, which can reach as high as 57.8°C when AMF applied for 300 s. This method provides a direct path way of comparison hyperthermia ability of MNPs and serves as a good reference to choose MNPs and decides the therapy parameters based on the unique drug response of individual patient. |
| doi_str_mv | 10.1038/srep07216 |
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Two kinds of MNPs with different sizes and magnetic performance are chosen and their temperature increments at the surface area under an alternating magnetic field (AMF) are calculated and compared through the concentration variation of ds-DNA modified on the surface. The temperature difference between the surface area of MNPs and bulk solution is also investigated, which can reach as high as 57.8°C when AMF applied for 300 s. This method provides a direct path way of comparison hyperthermia ability of MNPs and serves as a good reference to choose MNPs and decides the therapy parameters based on the unique drug response of individual patient.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep07216</identifier><identifier>PMID: 25427561</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>639/301/357/354 ; 639/638/298/920 ; Dehydration - chemically induced ; Denaturation ; Deoxyribonucleic acid ; DNA ; DNA - chemistry ; Fever ; Fever - chemically induced ; Hot Temperature ; Humanities and Social Sciences ; Hybridization ; Hyperthermia ; Hyperthermia, Induced - methods ; Magnetic Fields ; Magnetics - methods ; Magnetite Nanoparticles - chemistry ; multidisciplinary ; Nanoparticles ; Science ; Surface area ; Temperature effects ; Thermodynamics</subject><ispartof>Scientific reports, 2014-11, Vol.4 (1), p.7216-7216, Article 7216</ispartof><rights>The Author(s) 2014</rights><rights>Copyright Nature Publishing Group Nov 2014</rights><rights>Copyright © 2014, Macmillan Publishers Limited. All rights reserved 2014 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-9ff3a1c5061535f6f64500f74f0b607627caaac22f2c340477d39cf05082a1bb3</citedby><cites>FETCH-LOGICAL-c438t-9ff3a1c5061535f6f64500f74f0b607627caaac22f2c340477d39cf05082a1bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245595/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245595/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25427561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Lina</creatorcontrib><creatorcontrib>Liu, Jinming</creatorcontrib><creatorcontrib>Wu, Kai</creatorcontrib><creatorcontrib>Klein, Todd</creatorcontrib><creatorcontrib>Jiang, Yong</creatorcontrib><creatorcontrib>Wang, Jian-Ping</creatorcontrib><title>Evaluation of Hyperthermia of Magnetic Nanoparticles by Dehydrating DNA</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>A method based on the thermodynamic equilibrium reached between the hybridization and denaturation of double-stranded DNA (ds-DNA) is opened up to evaluate the hyperthermia performance of magnetic nanoparticles (MNPs). Two kinds of MNPs with different sizes and magnetic performance are chosen and their temperature increments at the surface area under an alternating magnetic field (AMF) are calculated and compared through the concentration variation of ds-DNA modified on the surface. The temperature difference between the surface area of MNPs and bulk solution is also investigated, which can reach as high as 57.8°C when AMF applied for 300 s. 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Liu, Jinming ; Wu, Kai ; Klein, Todd ; Jiang, Yong ; Wang, Jian-Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-9ff3a1c5061535f6f64500f74f0b607627caaac22f2c340477d39cf05082a1bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>639/301/357/354</topic><topic>639/638/298/920</topic><topic>Dehydration - chemically induced</topic><topic>Denaturation</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA - chemistry</topic><topic>Fever</topic><topic>Fever - chemically induced</topic><topic>Hot Temperature</topic><topic>Humanities and Social Sciences</topic><topic>Hybridization</topic><topic>Hyperthermia</topic><topic>Hyperthermia, Induced - methods</topic><topic>Magnetic Fields</topic><topic>Magnetics - methods</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>multidisciplinary</topic><topic>Nanoparticles</topic><topic>Science</topic><topic>Surface area</topic><topic>Temperature effects</topic><topic>Thermodynamics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Lina</creatorcontrib><creatorcontrib>Liu, Jinming</creatorcontrib><creatorcontrib>Wu, Kai</creatorcontrib><creatorcontrib>Klein, Todd</creatorcontrib><creatorcontrib>Jiang, Yong</creatorcontrib><creatorcontrib>Wang, Jian-Ping</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Lina</au><au>Liu, Jinming</au><au>Wu, Kai</au><au>Klein, Todd</au><au>Jiang, Yong</au><au>Wang, Jian-Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Hyperthermia of Magnetic Nanoparticles by Dehydrating DNA</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2014-11-27</date><risdate>2014</risdate><volume>4</volume><issue>1</issue><spage>7216</spage><epage>7216</epage><pages>7216-7216</pages><artnum>7216</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>A method based on the thermodynamic equilibrium reached between the hybridization and denaturation of double-stranded DNA (ds-DNA) is opened up to evaluate the hyperthermia performance of magnetic nanoparticles (MNPs). Two kinds of MNPs with different sizes and magnetic performance are chosen and their temperature increments at the surface area under an alternating magnetic field (AMF) are calculated and compared through the concentration variation of ds-DNA modified on the surface. The temperature difference between the surface area of MNPs and bulk solution is also investigated, which can reach as high as 57.8°C when AMF applied for 300 s. This method provides a direct path way of comparison hyperthermia ability of MNPs and serves as a good reference to choose MNPs and decides the therapy parameters based on the unique drug response of individual patient.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25427561</pmid><doi>10.1038/srep07216</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 639/301/357/354 639/638/298/920 Dehydration - chemically induced Denaturation Deoxyribonucleic acid DNA DNA - chemistry Fever Fever - chemically induced Hot Temperature Humanities and Social Sciences Hybridization Hyperthermia Hyperthermia, Induced - methods Magnetic Fields Magnetics - methods Magnetite Nanoparticles - chemistry multidisciplinary Nanoparticles Science Surface area Temperature effects Thermodynamics |
| title | Evaluation of Hyperthermia of Magnetic Nanoparticles by Dehydrating DNA |
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