Rates of bone loss in the appendicular and axial skeletons of women: evidence of substantial vertebral bone loss before menopause
We made longitudinal measurements of bone mineral density (BMD) in 139 normal women (ages 20-88 yr) at midradius (99% cortical bone) and lumbar spine (approximately 70% trabecular bone) by single- and dual-photon absorptiometry. BMD was measured 2-6 (median, 3) times over an interval of 0.8-3.4 yr (...
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| Veröffentlicht in: | The Journal of clinical investigation 1986-05, Vol.77 (5), p.1487-1491 |
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| container_title | The Journal of clinical investigation |
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| creator | RIGGS, B. L WAHNER, H. W MELTON, L. J. III RICHELSON, L. S JUDD, H. L OFFORD, K. P |
| description | We made longitudinal measurements of bone mineral density (BMD) in 139 normal women (ages 20-88 yr) at midradius (99% cortical bone) and lumbar spine (approximately 70% trabecular bone) by single- and dual-photon absorptiometry. BMD was measured 2-6 (median, 3) times over an interval of 0.8-3.4 yr (median, 2.1 yr). For midradius, BMD did not change (+0.48%/yr, NS) before menopause but decreased (-1.01%/yr, P less than 0.001) after menopause. For lumbar spine, there was significant bone loss both before (-1.32%/yr, P less than 0.001) and after (-0.97%/yr, P = 0.006) menopause; these rates did not differ significantly from each other. Our data show that before menopause little, if any, bone is lost from the appendicular skeleton but substantial amounts are lost from the axial skeleton. Thus, factors in addition to estrogen deficiency must contribute to pathogenesis of involutional osteoporosis in women because about half of overall vertebral bone loss occurs premenopausally. |
| doi_str_mv | 10.1172/jci112462 |
| format | Article |
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L ; WAHNER, H. W ; MELTON, L. J. III ; RICHELSON, L. S ; JUDD, H. L ; OFFORD, K. P</creator><creatorcontrib>RIGGS, B. L ; WAHNER, H. W ; MELTON, L. J. III ; RICHELSON, L. S ; JUDD, H. L ; OFFORD, K. P</creatorcontrib><description>We made longitudinal measurements of bone mineral density (BMD) in 139 normal women (ages 20-88 yr) at midradius (99% cortical bone) and lumbar spine (approximately 70% trabecular bone) by single- and dual-photon absorptiometry. BMD was measured 2-6 (median, 3) times over an interval of 0.8-3.4 yr (median, 2.1 yr). For midradius, BMD did not change (+0.48%/yr, NS) before menopause but decreased (-1.01%/yr, P less than 0.001) after menopause. For lumbar spine, there was significant bone loss both before (-1.32%/yr, P less than 0.001) and after (-0.97%/yr, P = 0.006) menopause; these rates did not differ significantly from each other. Our data show that before menopause little, if any, bone is lost from the appendicular skeleton but substantial amounts are lost from the axial skeleton. Thus, factors in addition to estrogen deficiency must contribute to pathogenesis of involutional osteoporosis in women because about half of overall vertebral bone loss occurs premenopausally.</description><identifier>ISSN: 0021-9738</identifier><identifier>EISSN: 1558-8238</identifier><identifier>DOI: 10.1172/jci112462</identifier><identifier>PMID: 3700651</identifier><identifier>CODEN: JCINAO</identifier><language>eng</language><publisher>Ann Arbor, MI: American Society for Clinical Investigation</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Bone and Bones - analysis ; Densitometry ; Estradiol - blood ; Estrone - blood ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Lumbar Vertebrae - analysis ; Medical sciences ; Menopause ; Middle Aged ; Minerals - analysis ; Osteoporosis - etiology ; Puberal and climacteric disorders (male and female) ; Sex Hormone-Binding Globulin - analysis ; Testosterone - blood</subject><ispartof>The Journal of clinical investigation, 1986-05, Vol.77 (5), p.1487-1491</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-6f9892b7a8defa391286ec1161462fce9f69ec74f9cf307407cac4c9a27e26cc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC424550/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC424550/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8699344$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3700651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RIGGS, B. L</creatorcontrib><creatorcontrib>WAHNER, H. W</creatorcontrib><creatorcontrib>MELTON, L. J. III</creatorcontrib><creatorcontrib>RICHELSON, L. S</creatorcontrib><creatorcontrib>JUDD, H. L</creatorcontrib><creatorcontrib>OFFORD, K. P</creatorcontrib><title>Rates of bone loss in the appendicular and axial skeletons of women: evidence of substantial vertebral bone loss before menopause</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>We made longitudinal measurements of bone mineral density (BMD) in 139 normal women (ages 20-88 yr) at midradius (99% cortical bone) and lumbar spine (approximately 70% trabecular bone) by single- and dual-photon absorptiometry. BMD was measured 2-6 (median, 3) times over an interval of 0.8-3.4 yr (median, 2.1 yr). For midradius, BMD did not change (+0.48%/yr, NS) before menopause but decreased (-1.01%/yr, P less than 0.001) after menopause. For lumbar spine, there was significant bone loss both before (-1.32%/yr, P less than 0.001) and after (-0.97%/yr, P = 0.006) menopause; these rates did not differ significantly from each other. Our data show that before menopause little, if any, bone is lost from the appendicular skeleton but substantial amounts are lost from the axial skeleton. Thus, factors in addition to estrogen deficiency must contribute to pathogenesis of involutional osteoporosis in women because about half of overall vertebral bone loss occurs premenopausally.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - analysis</subject><subject>Densitometry</subject><subject>Estradiol - blood</subject><subject>Estrone - blood</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Lumbar Vertebrae - analysis</subject><subject>Medical sciences</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Minerals - analysis</subject><subject>Osteoporosis - etiology</subject><subject>Puberal and climacteric disorders (male and female)</subject><subject>Sex Hormone-Binding Globulin - analysis</subject><subject>Testosterone - blood</subject><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUFv1DAQhS0EKtvCgR-A5ANC4pBiO44dI3FAK0pbVUJCcI4mzpi6ZO1gOws98s_JsqsFTmPN-954Ro-QZ5ydc67F6zvrORdSiQdkxZumrVpRtw_JijHBK6Pr9jE5zfmOMS5lI0_ISa0ZUw1fkV-foGCm0dE-BqRjzJn6QMstUpgmDIO38wiJQhgo_PQw0vwNRywx_DH9iBsMbyhu_YDB4q6V5z4XCGXHbjEV7NPy-ju9RxcT0sUXJ5gzPiGPHIwZnx7qGfly8f7z-rK6-fjhav3uprJSyVIpZ1ojeg3tgA5qw0Wr0HKu-HK2s2icMmi1dMa6mmnJtAUrrQGhUShr6zPydj93mvsNDhZDWRbrpuQ3kO67CL77Xwn-tvsat50UsmnY4n958Kf4fcZcuo3PFscRAsY5d1q1TDa6XsBXe9Cm5d6E7vgHZ90uru56fbWPa2Gf_7vUkTzks-gvDjpkC6NLEKzPR6xVxtRS1r8BjPGgfA</recordid><startdate>19860501</startdate><enddate>19860501</enddate><creator>RIGGS, B. L</creator><creator>WAHNER, H. W</creator><creator>MELTON, L. J. III</creator><creator>RICHELSON, L. S</creator><creator>JUDD, H. L</creator><creator>OFFORD, K. P</creator><general>American Society for Clinical Investigation</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19860501</creationdate><title>Rates of bone loss in the appendicular and axial skeletons of women: evidence of substantial vertebral bone loss before menopause</title><author>RIGGS, B. L ; WAHNER, H. W ; MELTON, L. J. III ; RICHELSON, L. S ; JUDD, H. L ; OFFORD, K. 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Obstetrics</topic><topic>Humans</topic><topic>Lumbar Vertebrae - analysis</topic><topic>Medical sciences</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Minerals - analysis</topic><topic>Osteoporosis - etiology</topic><topic>Puberal and climacteric disorders (male and female)</topic><topic>Sex Hormone-Binding Globulin - analysis</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RIGGS, B. L</creatorcontrib><creatorcontrib>WAHNER, H. W</creatorcontrib><creatorcontrib>MELTON, L. J. III</creatorcontrib><creatorcontrib>RICHELSON, L. S</creatorcontrib><creatorcontrib>JUDD, H. L</creatorcontrib><creatorcontrib>OFFORD, K. 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For lumbar spine, there was significant bone loss both before (-1.32%/yr, P less than 0.001) and after (-0.97%/yr, P = 0.006) menopause; these rates did not differ significantly from each other. Our data show that before menopause little, if any, bone is lost from the appendicular skeleton but substantial amounts are lost from the axial skeleton. Thus, factors in addition to estrogen deficiency must contribute to pathogenesis of involutional osteoporosis in women because about half of overall vertebral bone loss occurs premenopausally.</abstract><cop>Ann Arbor, MI</cop><pub>American Society for Clinical Investigation</pub><pmid>3700651</pmid><doi>10.1172/jci112462</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of clinical investigation, 1986-05, Vol.77 (5), p.1487-1491 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Biological and medical sciences Bone and Bones - analysis Densitometry Estradiol - blood Estrone - blood Female Gynecology. Andrology. Obstetrics Humans Lumbar Vertebrae - analysis Medical sciences Menopause Middle Aged Minerals - analysis Osteoporosis - etiology Puberal and climacteric disorders (male and female) Sex Hormone-Binding Globulin - analysis Testosterone - blood |
| title | Rates of bone loss in the appendicular and axial skeletons of women: evidence of substantial vertebral bone loss before menopause |
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