Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations

Previous studies have emphasized ethnically heterogeneous human leukocyte antigen (HLA) classical allele associations to rheumatoid arthritis (RA) risk. We fine-mapped RA risk alleles within the major histocompatibility complex (MHC) in 2782 seropositive RA cases and 4315 controls of Asian descent....

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Veröffentlicht in:	Human molecular genetics 2014-12, Vol.23 (25), p.6916-6926
Hauptverfasser:	Okada, Yukinori, Kim, Kwangwoo, Han, Buhm, Pillai, Nisha E, Ong, Rick T-H, Saw, Woei-Yuh, Luo, Ma, Jiang, Lei, Yin, Jian, Bang, So-Young, Lee, Hye-Soon, Brown, Matthew A, Bae, Sang-Cheol, Xu, Huji, Teo, Yik-Ying, de Bakker, Paul I W, Raychaudhuri, Soumya
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acids - genetics Amino Acids - immunology Arthritis, Rheumatoid - ethnology Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Asians Association Studies Autoantibodies - biosynthesis Chromosome Mapping Citrulline - immunology Epitopes - chemistry Epitopes - immunology Gene Expression Gene Frequency HLA-B Antigens - genetics HLA-B Antigens - immunology HLA-DP beta-Chains - genetics HLA-DP beta-Chains - immunology HLA-DRB1 Chains - genetics HLA-DRB1 Chains - immunology Humans Polymorphism, Genetic Risk Whites
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