Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

Depending on endoplasmic reticulum (ER) stress levels, the ER transmembrane multidomain protein IRE1α promotes either adaptation or apoptosis. Unfolded ER proteins cause IRE1α lumenal domain homo-oligomerization, inducing trans autophosphorylation that further drives homo-oligomerization of its cyto...

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Veröffentlicht in:	Cell 2014-07, Vol.158 (3), p.534-548
Hauptverfasser:	Ghosh, Rajarshi, Wang, Likun, Wang, Eric S., Perera, B. Gayani K., Igbaria, Aeid, Morita, Shuhei, Prado, Kris, Thamsen, Maike, Caswell, Deborah, Macias, Hector, Weiberth, Kurt F., Gliedt, Micah J., Alavi, Marcel V., Hari, Sanjay B., Mitra, Arinjay K., Bhhatarai, Barun, Schürer, Stephan C., Snapp, Erik L., Gould, Douglas B., German, Michael S., Backes, Bradley J., Maly, Dustin J., Oakes, Scott A., Papa, Feroz R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation animal disease models Animals apoptosis Apoptosis - drug effects Cell Line cell viability diabetes endoplasmic reticulum Endoplasmic Reticulum Stress Endoribonucleases - antagonists & inhibitors Endoribonucleases - chemistry Endoribonucleases - metabolism Enzyme Activation - drug effects Humans hyperglycemia insulin islets of Langerhans Islets of Langerhans - metabolism macular degeneration Male messenger RNA Mice oligomerization photoreceptors Protein Kinase Inhibitors - pharmacology protein phosphorylation Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - chemistry Protein Serine-Threonine Kinases - metabolism Rats Retina - metabolism ribonucleases Ribonucleases - antagonists & inhibitors transcription factors
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