Relation between geometric dimensions of coronary artery stenoses and myocardial perfusion reserve in man
To determine the relation between stenosis anatomy and perfusion in man, 31 patients had quantitative coronary arteriography and positron imaging (PET) with Rb-82 or N-13 ammonia at rest and after dipyridamole-handgrip stress. 10 patients were also studied after angioplasty (total stenoses = 41). Pe...
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| Veröffentlicht in: | The Journal of clinical investigation 1987-05, Vol.79 (5), p.1473-1478 |
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| container_issue | 5 |
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| container_title | The Journal of clinical investigation |
| container_volume | 79 |
| creator | GOLDSTEIN, R. A KIRKEEIDE, R. L DEMER, L. L MERHIGE, M NISHIKAWA, A SMALLING, R. W MULLANI, N. A GOULD, K. L |
| description | To determine the relation between stenosis anatomy and perfusion in man, 31 patients had quantitative coronary arteriography and positron imaging (PET) with Rb-82 or N-13 ammonia at rest and after dipyridamole-handgrip stress. 10 patients were also studied after angioplasty (total stenoses = 41). Percent narrowing and absolute cross-sectional luminal area were related through a quadratic function to myocardial perfusion reserve determined with PET. Arteriographically determined coronary flow reserve was linearly related to relative myocardial perfusion reserve as expected, based on the derivation of equations for stenosis flow reserve. All of the correlations had considerable scatter, indicating that no single measurement derived by coronary arteriography was a good indicator of perfusion reserve by PET in individual patients. This study provides the relation between all anatomic dimensions of coronary artery stenoses and myocardial perfusion reserve in man, and suggests that PET indicates the functional significance of coronary artery stenoses for clinical purposes. |
| doi_str_mv | 10.1172/jci112976 |
| format | Article |
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A ; KIRKEEIDE, R. L ; DEMER, L. L ; MERHIGE, M ; NISHIKAWA, A ; SMALLING, R. W ; MULLANI, N. A ; GOULD, K. L</creator><creatorcontrib>GOLDSTEIN, R. A ; KIRKEEIDE, R. L ; DEMER, L. L ; MERHIGE, M ; NISHIKAWA, A ; SMALLING, R. W ; MULLANI, N. A ; GOULD, K. L</creatorcontrib><description>To determine the relation between stenosis anatomy and perfusion in man, 31 patients had quantitative coronary arteriography and positron imaging (PET) with Rb-82 or N-13 ammonia at rest and after dipyridamole-handgrip stress. 10 patients were also studied after angioplasty (total stenoses = 41). Percent narrowing and absolute cross-sectional luminal area were related through a quadratic function to myocardial perfusion reserve determined with PET. Arteriographically determined coronary flow reserve was linearly related to relative myocardial perfusion reserve as expected, based on the derivation of equations for stenosis flow reserve. All of the correlations had considerable scatter, indicating that no single measurement derived by coronary arteriography was a good indicator of perfusion reserve by PET in individual patients. This study provides the relation between all anatomic dimensions of coronary artery stenoses and myocardial perfusion reserve in man, and suggests that PET indicates the functional significance of coronary artery stenoses for clinical purposes.</description><identifier>ISSN: 0021-9738</identifier><identifier>EISSN: 1558-8238</identifier><identifier>DOI: 10.1172/jci112976</identifier><identifier>PMID: 3494749</identifier><identifier>CODEN: JCINAO</identifier><language>eng</language><publisher>Ann Arbor, MI: American Society for Clinical Investigation</publisher><subject>Arterial Occlusive Diseases - pathology ; Biological and medical sciences ; Cardiac Catheterization ; Cardiology. Vascular system ; Coronary Circulation ; Coronary heart disease ; Coronary Vessels ; Female ; Heart ; Humans ; Male ; Mathematics ; Medical sciences ; Perfusion ; Tomography, Emission-Computed</subject><ispartof>The Journal of clinical investigation, 1987-05, Vol.79 (5), p.1473-1478</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-da29ff6e04ec26e7512c713cf02e6c35bb5160400660dbd8bb7fa69fd8fc70933</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC424422/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC424422/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8367453$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3494749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOLDSTEIN, R. A</creatorcontrib><creatorcontrib>KIRKEEIDE, R. L</creatorcontrib><creatorcontrib>DEMER, L. L</creatorcontrib><creatorcontrib>MERHIGE, M</creatorcontrib><creatorcontrib>NISHIKAWA, A</creatorcontrib><creatorcontrib>SMALLING, R. W</creatorcontrib><creatorcontrib>MULLANI, N. A</creatorcontrib><creatorcontrib>GOULD, K. L</creatorcontrib><title>Relation between geometric dimensions of coronary artery stenoses and myocardial perfusion reserve in man</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>To determine the relation between stenosis anatomy and perfusion in man, 31 patients had quantitative coronary arteriography and positron imaging (PET) with Rb-82 or N-13 ammonia at rest and after dipyridamole-handgrip stress. 10 patients were also studied after angioplasty (total stenoses = 41). Percent narrowing and absolute cross-sectional luminal area were related through a quadratic function to myocardial perfusion reserve determined with PET. Arteriographically determined coronary flow reserve was linearly related to relative myocardial perfusion reserve as expected, based on the derivation of equations for stenosis flow reserve. All of the correlations had considerable scatter, indicating that no single measurement derived by coronary arteriography was a good indicator of perfusion reserve by PET in individual patients. This study provides the relation between all anatomic dimensions of coronary artery stenoses and myocardial perfusion reserve in man, and suggests that PET indicates the functional significance of coronary artery stenoses for clinical purposes.</description><subject>Arterial Occlusive Diseases - pathology</subject><subject>Biological and medical sciences</subject><subject>Cardiac Catheterization</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Circulation</subject><subject>Coronary heart disease</subject><subject>Coronary Vessels</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Mathematics</subject><subject>Medical sciences</subject><subject>Perfusion</subject><subject>Tomography, Emission-Computed</subject><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU9r3DAUxEVISTfbHPIBCjqEQg5u9V_2IYewtEnKQqG0ZyHLT4mCLW0ke8t--zrssiSnOcxv3hsYhC4p-UqpZt-eXaCUNVqdoAWVsq5qxutTtCCE0arRvP6Izkt5JoQKIcUZOuOiEVo0CxR-Q2_HkCJuYfwHEPEjpAHGHBzuwgCxzF7ByWOXcoo277DNI8xSRoipQME2dnjYJWdzF2yPN5D99JrCGQrkLeAQ8WDjJ_TB277AxUGX6O-P739W99X6193D6nZdOaHEWHWWNd4rIAIcU6AlZU5T7jxhoByXbSupIoIQpUjXdnXbam9V47vaO00azpfoZn93M7UDdA7imG1vNjkMc3uTbDDvnRiezGPaGsGEYGzOfznkc3qZoIxmCMVB39sIaSpGa1ELKdUMXu9Bl1MpGfzxByXmdRbzc_Wwn2VmP78tdSQPO8z-1cG3xdneZxtdKEes5koLyfl_vEmYnQ</recordid><startdate>19870501</startdate><enddate>19870501</enddate><creator>GOLDSTEIN, R. 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L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation between geometric dimensions of coronary artery stenoses and myocardial perfusion reserve in man</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>1987-05-01</date><risdate>1987</risdate><volume>79</volume><issue>5</issue><spage>1473</spage><epage>1478</epage><pages>1473-1478</pages><issn>0021-9738</issn><eissn>1558-8238</eissn><coden>JCINAO</coden><abstract>To determine the relation between stenosis anatomy and perfusion in man, 31 patients had quantitative coronary arteriography and positron imaging (PET) with Rb-82 or N-13 ammonia at rest and after dipyridamole-handgrip stress. 10 patients were also studied after angioplasty (total stenoses = 41). Percent narrowing and absolute cross-sectional luminal area were related through a quadratic function to myocardial perfusion reserve determined with PET. Arteriographically determined coronary flow reserve was linearly related to relative myocardial perfusion reserve as expected, based on the derivation of equations for stenosis flow reserve. All of the correlations had considerable scatter, indicating that no single measurement derived by coronary arteriography was a good indicator of perfusion reserve by PET in individual patients. This study provides the relation between all anatomic dimensions of coronary artery stenoses and myocardial perfusion reserve in man, and suggests that PET indicates the functional significance of coronary artery stenoses for clinical purposes.</abstract><cop>Ann Arbor, MI</cop><pub>American Society for Clinical Investigation</pub><pmid>3494749</pmid><doi>10.1172/jci112976</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Arterial Occlusive Diseases - pathology Biological and medical sciences Cardiac Catheterization Cardiology. Vascular system Coronary Circulation Coronary heart disease Coronary Vessels Female Heart Humans Male Mathematics Medical sciences Perfusion Tomography, Emission-Computed |
| title | Relation between geometric dimensions of coronary artery stenoses and myocardial perfusion reserve in man |
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