KITLG is a novel target of miR‐34c that is associated with the inhibition of growth and invasion in colorectal cancer cells

MiR‐34c is considered a potent tumour suppressor because of its negative regulation of multiple target mRNAs that are critically associated with tumorigenesis and metastasis. In the present study, we demonstrated a novel target of miR‐34c, KITLG, which has been implicated in colorectal cancer (CRC)....

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Veröffentlicht in:	Journal of cellular and molecular medicine 2014-10, Vol.18 (10), p.2092-2102
Hauptverfasser:	Yang, Shu, Li, Wen‐shuai, Dong, Fang, Sun, Hai‐mei, Wu, Bo, Tan, Jun, Zou, Wan‐jing, Zhou, De‐shan
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Apoptosis Blotting, Western Cell Cycle Cell growth Cell Movement Cell Proliferation Colorectal cancer colorectal cancer cell Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms - prevention & control Fluorescent Antibody Technique Gene expression Gene Expression Regulation, Neoplastic Humans Infections KITLG Metastases Metastasis MicroRNAs MicroRNAs - genetics miR‐34c Original Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics siRNA Stem Cell Factor - antagonists & inhibitors Stem Cell Factor - genetics Stem Cell Factor - metabolism Stem cells Tumor Cells, Cultured Tumorigenesis Tumors tumour suppressor
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