Involvement of substance P in the development of cisplatin‐induced acute and delayed pica in rats
Background and Purpose Although substance P (SP) and neurokinin NK1 receptors have been reported to be involved in cisplatin‐induced acute and delayed emesis, their precise roles remain unclear. Pica, the consumption of non‐nutrient materials such as kaolin in rats, can be used as a model of nausea...
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| Veröffentlicht in: | British journal of pharmacology 2014-06, Vol.171 (11), p.2888-2899 |
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| container_title | British journal of pharmacology |
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| creator | Yamamoto, Kouichi Asano, Keiko Tasaka, Ayana Ogura, Yuko Kim, Seikou Ito, Yui Yamatodani, Atsushi |
| description | Background and Purpose
Although substance P (SP) and neurokinin NK1 receptors have been reported to be involved in cisplatin‐induced acute and delayed emesis, their precise roles remain unclear. Pica, the consumption of non‐nutrient materials such as kaolin in rats, can be used as a model of nausea in humans. We investigated the time‐dependent changes in cisplatin‐induced pica and the involvement of SP and NK1 receptors in this behaviour.
Experimental Approach
Rats were administered cisplatin with or without a daily injection of a 5‐HT3 receptor antagonist (granisetron) or an NK1 receptor antagonist (aprepitant), and kaolin intake was then monitored for 5 days. The effects of granisetron on the cisplatin‐induced expression of preprotachykinin‐A (PPT‐A) mRNA, which encodes mainly for SP, and on SP release in the medulla, measured by in vivo brain microdialysis, were also investigated.
Key Results
Cisplatin induced pica within 8 h of its administration that continued for 5 days. Granisetron inhibited the acute phase (day 1), but not the delayed phase (days 2–5), of pica, whereas aprepitant abolished both phases. Within 24 h of the injection of cisplatin, PPT‐A mRNA expression and SP release in the medulla were significantly increased; these findings lasted during the observation period and were inhibited by granisetron for up to 24 h.
Conclusions and Implications
The profiles of cisplatin‐induced pica in rats are similar to clinical findings for cisplatin‐induced emesis in humans, and we showed that SP production in the medulla and activation of NK1 receptors are involved in this cisplatin‐induced pica. |
| doi_str_mv | 10.1111/bph.12629 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4243862</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3963169171</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5099-d82c95122f389624463a86602f9138f557f01d5add04236a2752f9844db5e8e03</originalsourceid><addsrcrecordid>eNp1kUFLwzAYhoMobk4P_gEpePLQLUmTNL0IOtQNBu6g55Alqcvo0tq0k938Cf5Gf4mZ20QP5vJB3ofn--AF4BzBPgpvMKvmfYQZzg5AF5GUxTTh6BB0IYRpjBDnHXDi_QLCEKb0GHQwYQSxDHeBGrtVWazM0rgmKvPItzPfSKdMNI2si5q5ibRZmaKs9oSyvipkY93n-4d1ulVGR1K1jYmk0wEu5Dr8VFbJjaCWjT8FR7ksvDnbzR54vr97Go7iyePDeHgziRWFWRZrjlVGEcZ5wjOGCWGJ5IxBnGco4TmlaQ6RplJrSHDCJE5piDghekYNNzDpgeutt2pnS6NVOLiWhahqu5T1WpTSir-Js3PxUq4EwSThDAfB5U5Ql6-t8Y1YlG3tws0CpSzNGIJss-ZqS6m69L42-c8GBMWmDxH6EN99BPbi90k_5L6AAAy2wJstzPp_k7idjrbKL-tslag</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1767961060</pqid></control><display><type>article</type><title>Involvement of substance P in the development of cisplatin‐induced acute and delayed pica in rats</title><source>Wiley-Blackwell Journals</source><source>MEDLINE</source><source>Wiley Free Archive</source><source>PubMed (Medline)</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Yamamoto, Kouichi ; Asano, Keiko ; Tasaka, Ayana ; Ogura, Yuko ; Kim, Seikou ; Ito, Yui ; Yamatodani, Atsushi</creator><creatorcontrib>Yamamoto, Kouichi ; Asano, Keiko ; Tasaka, Ayana ; Ogura, Yuko ; Kim, Seikou ; Ito, Yui ; Yamatodani, Atsushi</creatorcontrib><description>Background and Purpose
Although substance P (SP) and neurokinin NK1 receptors have been reported to be involved in cisplatin‐induced acute and delayed emesis, their precise roles remain unclear. Pica, the consumption of non‐nutrient materials such as kaolin in rats, can be used as a model of nausea in humans. We investigated the time‐dependent changes in cisplatin‐induced pica and the involvement of SP and NK1 receptors in this behaviour.
Experimental Approach
Rats were administered cisplatin with or without a daily injection of a 5‐HT3 receptor antagonist (granisetron) or an NK1 receptor antagonist (aprepitant), and kaolin intake was then monitored for 5 days. The effects of granisetron on the cisplatin‐induced expression of preprotachykinin‐A (PPT‐A) mRNA, which encodes mainly for SP, and on SP release in the medulla, measured by in vivo brain microdialysis, were also investigated.
Key Results
Cisplatin induced pica within 8 h of its administration that continued for 5 days. Granisetron inhibited the acute phase (day 1), but not the delayed phase (days 2–5), of pica, whereas aprepitant abolished both phases. Within 24 h of the injection of cisplatin, PPT‐A mRNA expression and SP release in the medulla were significantly increased; these findings lasted during the observation period and were inhibited by granisetron for up to 24 h.
Conclusions and Implications
The profiles of cisplatin‐induced pica in rats are similar to clinical findings for cisplatin‐induced emesis in humans, and we showed that SP production in the medulla and activation of NK1 receptors are involved in this cisplatin‐induced pica.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/bph.12629</identifier><identifier>PMID: 24641692</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>5‐HT3 receptor ; acute emesis ; Animals ; Antiemetics - pharmacology ; Antineoplastic Agents ; brain microdialysis ; Cisplatin ; delayed emesis ; Eating ; Granisetron - pharmacology ; Kaolin - administration & dosage ; Male ; medulla ; Medulla Oblongata - drug effects ; Medulla Oblongata - metabolism ; Morpholines - pharmacology ; Nausea - chemically induced ; Nausea - metabolism ; neurokinin NK1 receptor ; Neurokinin-1 Receptor Antagonists - pharmacology ; pica ; Pica - chemically induced ; Pica - metabolism ; preprotachykinin‐A ; Protein Precursors - genetics ; Rats, Wistar ; Receptors, Neurokinin-1 - metabolism ; Receptors, Serotonin, 5-HT3 - metabolism ; Research Papers ; RNA, Messenger - metabolism ; Rodents ; Serotonin Antagonists - pharmacology ; Solitary Nucleus - drug effects ; Solitary Nucleus - metabolism ; substance P ; Substance P - metabolism ; Tachykinins - genetics</subject><ispartof>British journal of pharmacology, 2014-06, Vol.171 (11), p.2888-2899</ispartof><rights>2014 The British Pharmacological Society</rights><rights>2014 The British Pharmacological Society.</rights><rights>Copyright © 2014 The British Pharmacological Society</rights><rights>2014 The British Pharmacological Society 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5099-d82c95122f389624463a86602f9138f557f01d5add04236a2752f9844db5e8e03</citedby><cites>FETCH-LOGICAL-c5099-d82c95122f389624463a86602f9138f557f01d5add04236a2752f9844db5e8e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243862/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243862/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24641692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamoto, Kouichi</creatorcontrib><creatorcontrib>Asano, Keiko</creatorcontrib><creatorcontrib>Tasaka, Ayana</creatorcontrib><creatorcontrib>Ogura, Yuko</creatorcontrib><creatorcontrib>Kim, Seikou</creatorcontrib><creatorcontrib>Ito, Yui</creatorcontrib><creatorcontrib>Yamatodani, Atsushi</creatorcontrib><title>Involvement of substance P in the development of cisplatin‐induced acute and delayed pica in rats</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>Background and Purpose
Although substance P (SP) and neurokinin NK1 receptors have been reported to be involved in cisplatin‐induced acute and delayed emesis, their precise roles remain unclear. Pica, the consumption of non‐nutrient materials such as kaolin in rats, can be used as a model of nausea in humans. We investigated the time‐dependent changes in cisplatin‐induced pica and the involvement of SP and NK1 receptors in this behaviour.
Experimental Approach
Rats were administered cisplatin with or without a daily injection of a 5‐HT3 receptor antagonist (granisetron) or an NK1 receptor antagonist (aprepitant), and kaolin intake was then monitored for 5 days. The effects of granisetron on the cisplatin‐induced expression of preprotachykinin‐A (PPT‐A) mRNA, which encodes mainly for SP, and on SP release in the medulla, measured by in vivo brain microdialysis, were also investigated.
Key Results
Cisplatin induced pica within 8 h of its administration that continued for 5 days. Granisetron inhibited the acute phase (day 1), but not the delayed phase (days 2–5), of pica, whereas aprepitant abolished both phases. Within 24 h of the injection of cisplatin, PPT‐A mRNA expression and SP release in the medulla were significantly increased; these findings lasted during the observation period and were inhibited by granisetron for up to 24 h.
Conclusions and Implications
The profiles of cisplatin‐induced pica in rats are similar to clinical findings for cisplatin‐induced emesis in humans, and we showed that SP production in the medulla and activation of NK1 receptors are involved in this cisplatin‐induced pica.</description><subject>5‐HT3 receptor</subject><subject>acute emesis</subject><subject>Animals</subject><subject>Antiemetics - pharmacology</subject><subject>Antineoplastic Agents</subject><subject>brain microdialysis</subject><subject>Cisplatin</subject><subject>delayed emesis</subject><subject>Eating</subject><subject>Granisetron - pharmacology</subject><subject>Kaolin - administration & dosage</subject><subject>Male</subject><subject>medulla</subject><subject>Medulla Oblongata - drug effects</subject><subject>Medulla Oblongata - metabolism</subject><subject>Morpholines - pharmacology</subject><subject>Nausea - chemically induced</subject><subject>Nausea - metabolism</subject><subject>neurokinin NK1 receptor</subject><subject>Neurokinin-1 Receptor Antagonists - pharmacology</subject><subject>pica</subject><subject>Pica - chemically induced</subject><subject>Pica - metabolism</subject><subject>preprotachykinin‐A</subject><subject>Protein Precursors - genetics</subject><subject>Rats, Wistar</subject><subject>Receptors, Neurokinin-1 - metabolism</subject><subject>Receptors, Serotonin, 5-HT3 - metabolism</subject><subject>Research Papers</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Solitary Nucleus - drug effects</subject><subject>Solitary Nucleus - metabolism</subject><subject>substance P</subject><subject>Substance P - metabolism</subject><subject>Tachykinins - genetics</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFLwzAYhoMobk4P_gEpePLQLUmTNL0IOtQNBu6g55Alqcvo0tq0k938Cf5Gf4mZ20QP5vJB3ofn--AF4BzBPgpvMKvmfYQZzg5AF5GUxTTh6BB0IYRpjBDnHXDi_QLCEKb0GHQwYQSxDHeBGrtVWazM0rgmKvPItzPfSKdMNI2si5q5ibRZmaKs9oSyvipkY93n-4d1ulVGR1K1jYmk0wEu5Dr8VFbJjaCWjT8FR7ksvDnbzR54vr97Go7iyePDeHgziRWFWRZrjlVGEcZ5wjOGCWGJ5IxBnGco4TmlaQ6RplJrSHDCJE5piDghekYNNzDpgeutt2pnS6NVOLiWhahqu5T1WpTSir-Js3PxUq4EwSThDAfB5U5Ql6-t8Y1YlG3tws0CpSzNGIJss-ZqS6m69L42-c8GBMWmDxH6EN99BPbi90k_5L6AAAy2wJstzPp_k7idjrbKL-tslag</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>Yamamoto, Kouichi</creator><creator>Asano, Keiko</creator><creator>Tasaka, Ayana</creator><creator>Ogura, Yuko</creator><creator>Kim, Seikou</creator><creator>Ito, Yui</creator><creator>Yamatodani, Atsushi</creator><general>Blackwell Publishing Ltd</general><general>BlackWell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>5PM</scope></search><sort><creationdate>201406</creationdate><title>Involvement of substance P in the development of cisplatin‐induced acute and delayed pica in rats</title><author>Yamamoto, Kouichi ; Asano, Keiko ; Tasaka, Ayana ; Ogura, Yuko ; Kim, Seikou ; Ito, Yui ; Yamatodani, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5099-d82c95122f389624463a86602f9138f557f01d5add04236a2752f9844db5e8e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>5‐HT3 receptor</topic><topic>acute emesis</topic><topic>Animals</topic><topic>Antiemetics - pharmacology</topic><topic>Antineoplastic Agents</topic><topic>brain microdialysis</topic><topic>Cisplatin</topic><topic>delayed emesis</topic><topic>Eating</topic><topic>Granisetron - pharmacology</topic><topic>Kaolin - administration & dosage</topic><topic>Male</topic><topic>medulla</topic><topic>Medulla Oblongata - drug effects</topic><topic>Medulla Oblongata - metabolism</topic><topic>Morpholines - pharmacology</topic><topic>Nausea - chemically induced</topic><topic>Nausea - metabolism</topic><topic>neurokinin NK1 receptor</topic><topic>Neurokinin-1 Receptor Antagonists - pharmacology</topic><topic>pica</topic><topic>Pica - chemically induced</topic><topic>Pica - metabolism</topic><topic>preprotachykinin‐A</topic><topic>Protein Precursors - genetics</topic><topic>Rats, Wistar</topic><topic>Receptors, Neurokinin-1 - metabolism</topic><topic>Receptors, Serotonin, 5-HT3 - metabolism</topic><topic>Research Papers</topic><topic>RNA, Messenger - metabolism</topic><topic>Rodents</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Solitary Nucleus - drug effects</topic><topic>Solitary Nucleus - metabolism</topic><topic>substance P</topic><topic>Substance P - metabolism</topic><topic>Tachykinins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamoto, Kouichi</creatorcontrib><creatorcontrib>Asano, Keiko</creatorcontrib><creatorcontrib>Tasaka, Ayana</creatorcontrib><creatorcontrib>Ogura, Yuko</creatorcontrib><creatorcontrib>Kim, Seikou</creatorcontrib><creatorcontrib>Ito, Yui</creatorcontrib><creatorcontrib>Yamatodani, Atsushi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamoto, Kouichi</au><au>Asano, Keiko</au><au>Tasaka, Ayana</au><au>Ogura, Yuko</au><au>Kim, Seikou</au><au>Ito, Yui</au><au>Yamatodani, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of substance P in the development of cisplatin‐induced acute and delayed pica in rats</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>2014-06</date><risdate>2014</risdate><volume>171</volume><issue>11</issue><spage>2888</spage><epage>2899</epage><pages>2888-2899</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>Background and Purpose
Although substance P (SP) and neurokinin NK1 receptors have been reported to be involved in cisplatin‐induced acute and delayed emesis, their precise roles remain unclear. Pica, the consumption of non‐nutrient materials such as kaolin in rats, can be used as a model of nausea in humans. We investigated the time‐dependent changes in cisplatin‐induced pica and the involvement of SP and NK1 receptors in this behaviour.
Experimental Approach
Rats were administered cisplatin with or without a daily injection of a 5‐HT3 receptor antagonist (granisetron) or an NK1 receptor antagonist (aprepitant), and kaolin intake was then monitored for 5 days. The effects of granisetron on the cisplatin‐induced expression of preprotachykinin‐A (PPT‐A) mRNA, which encodes mainly for SP, and on SP release in the medulla, measured by in vivo brain microdialysis, were also investigated.
Key Results
Cisplatin induced pica within 8 h of its administration that continued for 5 days. Granisetron inhibited the acute phase (day 1), but not the delayed phase (days 2–5), of pica, whereas aprepitant abolished both phases. Within 24 h of the injection of cisplatin, PPT‐A mRNA expression and SP release in the medulla were significantly increased; these findings lasted during the observation period and were inhibited by granisetron for up to 24 h.
Conclusions and Implications
The profiles of cisplatin‐induced pica in rats are similar to clinical findings for cisplatin‐induced emesis in humans, and we showed that SP production in the medulla and activation of NK1 receptors are involved in this cisplatin‐induced pica.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24641692</pmid><doi>10.1111/bph.12629</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 5‐HT3 receptor acute emesis Animals Antiemetics - pharmacology Antineoplastic Agents brain microdialysis Cisplatin delayed emesis Eating Granisetron - pharmacology Kaolin - administration & dosage Male medulla Medulla Oblongata - drug effects Medulla Oblongata - metabolism Morpholines - pharmacology Nausea - chemically induced Nausea - metabolism neurokinin NK1 receptor Neurokinin-1 Receptor Antagonists - pharmacology pica Pica - chemically induced Pica - metabolism preprotachykinin‐A Protein Precursors - genetics Rats, Wistar Receptors, Neurokinin-1 - metabolism Receptors, Serotonin, 5-HT3 - metabolism Research Papers RNA, Messenger - metabolism Rodents Serotonin Antagonists - pharmacology Solitary Nucleus - drug effects Solitary Nucleus - metabolism substance P Substance P - metabolism Tachykinins - genetics |
| title | Involvement of substance P in the development of cisplatin‐induced acute and delayed pica in rats |
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