Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions?

Background and Purpose Cardiovascular risk is higher in men and postmenopausal women compared with premenopausal women. This may be due to sex differences in endothelial function. Here, sex differences in endothelial function of porcine coronary arteries (PCAs) were investigated. Experimental Approa...

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Veröffentlicht in:	British journal of pharmacology 2014-06, Vol.171 (11), p.2751-2766
Hauptverfasser:	Wong, P S, Roberts, R E, Randall, M D
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Animals Apamin - pharmacology bradykinin Bradykinin - pharmacology Carbenoxolone - pharmacology Catalase - pharmacology connexin (Cx) Connexins - metabolism Coronary Vessels - physiology Endothelium, Vascular - physiology endothelium‐derived hyperpolarization (EDH) Female gap junctions Gap Junctions - physiology Glycyrrhetinic Acid - analogs & derivatives Glycyrrhetinic Acid - pharmacology hydrogen peroxide (H2O2) Hydrogen Peroxide - pharmacology Indomethacin - pharmacology intermediate‐conductance calcium‐activated K+ channel (IKca) Male NG-Nitroarginine Methyl Ester - pharmacology nitric oxide (NO) Polyethylene Glycols - pharmacology porcine coronary artery (PCA) Pyrazoles - pharmacology Research Papers Sex Characteristics sex differences small‐conductance calcium‐activated K+ channel (SKca) Swine Vasoconstrictor Agents - pharmacology Vasodilation Vasodilator Agents - pharmacology
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