Heart ischaemia–reperfusion induces local up‐regulation of vasoconstrictor endothelin ETB receptors in rat coronary arteries downstream of occlusion

Background and Purpose Endothelins act via two receptor subtypes, ETA and ETB. Under physiological conditions in coronary arteries, ETA receptors expressed in smooth muscle cells mediate vasoconstriction whereas ETB receptors mainly found in endothelial cells mediate vasorelaxation. However, under p...

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Veröffentlicht in:	British journal of pharmacology 2014-06, Vol.171 (11), p.2726-2738
Hauptverfasser:	Skovsted, G F, Kruse, L S, Larsen, R, Pedersen, A F, Trautner, S, Sheykhzade, M, Edvinsson, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals coronary artery Coronary vessels Coronary Vessels - physiology endothelin Endothelin A Receptor Antagonists - pharmacology Endothelin B Receptor Antagonists - pharmacology endothelin receptor Hogs Ligation Male Muscle, Smooth, Vascular - physiology Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - physiopathology Myocytes, Smooth Muscle - physiology Oligopeptides - pharmacology Peptides, Cyclic - pharmacology Piperidines - pharmacology Rats, Sprague-Dawley Receptor, Endothelin A - physiology Receptor, Endothelin B - physiology Research Papers Rodents sarafotoxin 6c Smooth muscle Up-Regulation vascular smooth muscle Vasoconstriction Veins & arteries Viper Venoms - pharmacology
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