Camouflage and Misdirection: The Full-On Assault of Ebola Virus Disease
Ebolaviruses cause a severe hemorrhagic fever syndrome that is rapidly fatal to humans and nonhuman primates. Ebola protein interactions with host cellular proteins disrupt type I and type II interferon responses, RNAi antiviral responses, antigen presentation, T-cell-dependent B cell responses, hum...
Gespeichert in:
| Veröffentlicht in: | Cell 2014-10, Vol.159 (3), p.477-486 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 486 |
|---|---|
| container_issue | 3 |
| container_start_page | 477 |
| container_title | Cell |
| container_volume | 159 |
| creator | Misasi, John Sullivan, Nancy J. |
| description | Ebolaviruses cause a severe hemorrhagic fever syndrome that is rapidly fatal to humans and nonhuman primates. Ebola protein interactions with host cellular proteins disrupt type I and type II interferon responses, RNAi antiviral responses, antigen presentation, T-cell-dependent B cell responses, humoral antibodies, and cell-mediated immunity. This multifaceted approach to evasion and suppression of innate and adaptive immune responses in their target hosts leads to the severe immune dysregulation and “cytokine storm” that is characteristic of fatal ebolavirus infection. Here, we highlight some of the processes by which Ebola interacts with its mammalian hosts to evade antiviral defenses.
The current outbreak of Ebola warrants a detailed understanding of how members of this family of viruses suppress and evade host immune defenses and cause fatal hemorrhagic fever. |
| doi_str_mv | 10.1016/j.cell.2014.10.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4243531</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0092867414012938</els_id><sourcerecordid>1654677412</sourcerecordid><originalsourceid>FETCH-LOGICAL-c587t-5852abc02e37cbb5b0e119d32a1dab49632af06104e493d50ed5ee0852f5a9003</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhS0EokPpC7BAXrLJcO34J0EIqRragtSqm9Kt5Tg3rUeeuNhJpb49jqZUsIGubF1_5-j6HELeMVgzYOrjdu0whDUHJspgDaBekBWDVleCaf6SrABaXjVKiwPyJuctADRSytfkgMtCFI8VOdvYXZyHYG-Q2rGnFz73PqGbfBw_0atbpKdzCNXlSI9ztnOYaBzoSReDpdc-zZl-9Rltxrfk1WBDxqPH85D8OD252nyrzi_Pvm-OzysnGz1VspHcdg441tp1newAGWv7mlvW2060qtwGUAwEirbuJWAvEcvafJC2BagPyZe9793c7bB3OE7JBnOX_M6mBxOtN3-_jP7W3MR7I7ioZc2KwYdHgxR_zpgns_N5ydGOGOdseEmJcwVK_xdlSgqltWD8GaioBTSgZUH5HnUp5pxweFqegVl6NVuzKM3S6zIrvRbR-z-__ST5XWQBPu8BLOHfe0wmO4-jw32bpo_-X_6_AL8gsmw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1643408075</pqid></control><display><type>article</type><title>Camouflage and Misdirection: The Full-On Assault of Ebola Virus Disease</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Misasi, John ; Sullivan, Nancy J.</creator><creatorcontrib>Misasi, John ; Sullivan, Nancy J.</creatorcontrib><description>Ebolaviruses cause a severe hemorrhagic fever syndrome that is rapidly fatal to humans and nonhuman primates. Ebola protein interactions with host cellular proteins disrupt type I and type II interferon responses, RNAi antiviral responses, antigen presentation, T-cell-dependent B cell responses, humoral antibodies, and cell-mediated immunity. This multifaceted approach to evasion and suppression of innate and adaptive immune responses in their target hosts leads to the severe immune dysregulation and “cytokine storm” that is characteristic of fatal ebolavirus infection. Here, we highlight some of the processes by which Ebola interacts with its mammalian hosts to evade antiviral defenses.
The current outbreak of Ebola warrants a detailed understanding of how members of this family of viruses suppress and evade host immune defenses and cause fatal hemorrhagic fever.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/j.cell.2014.10.006</identifier><identifier>PMID: 25417101</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>antibodies ; antigen presentation ; cytokines ; Cytokines - immunology ; Ebola virus ; Ebolavirus ; Ebolavirus - physiology ; fever ; Hemorrhagic Fever, Ebola - immunology ; Hemorrhagic Fever, Ebola - virology ; hosts ; humans ; Immune Evasion ; Immune Tolerance ; Immunity, Humoral ; interferon-gamma ; Primates ; proteins ; RNA interference ; Viral Proteins - metabolism ; Virus Internalization</subject><ispartof>Cell, 2014-10, Vol.159 (3), p.477-486</ispartof><rights>2014 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-5852abc02e37cbb5b0e119d32a1dab49632af06104e493d50ed5ee0852f5a9003</citedby><cites>FETCH-LOGICAL-c587t-5852abc02e37cbb5b0e119d32a1dab49632af06104e493d50ed5ee0852f5a9003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0092867414012938$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25417101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Misasi, John</creatorcontrib><creatorcontrib>Sullivan, Nancy J.</creatorcontrib><title>Camouflage and Misdirection: The Full-On Assault of Ebola Virus Disease</title><title>Cell</title><addtitle>Cell</addtitle><description>Ebolaviruses cause a severe hemorrhagic fever syndrome that is rapidly fatal to humans and nonhuman primates. Ebola protein interactions with host cellular proteins disrupt type I and type II interferon responses, RNAi antiviral responses, antigen presentation, T-cell-dependent B cell responses, humoral antibodies, and cell-mediated immunity. This multifaceted approach to evasion and suppression of innate and adaptive immune responses in their target hosts leads to the severe immune dysregulation and “cytokine storm” that is characteristic of fatal ebolavirus infection. Here, we highlight some of the processes by which Ebola interacts with its mammalian hosts to evade antiviral defenses.
The current outbreak of Ebola warrants a detailed understanding of how members of this family of viruses suppress and evade host immune defenses and cause fatal hemorrhagic fever.</description><subject>antibodies</subject><subject>antigen presentation</subject><subject>cytokines</subject><subject>Cytokines - immunology</subject><subject>Ebola virus</subject><subject>Ebolavirus</subject><subject>Ebolavirus - physiology</subject><subject>fever</subject><subject>Hemorrhagic Fever, Ebola - immunology</subject><subject>Hemorrhagic Fever, Ebola - virology</subject><subject>hosts</subject><subject>humans</subject><subject>Immune Evasion</subject><subject>Immune Tolerance</subject><subject>Immunity, Humoral</subject><subject>interferon-gamma</subject><subject>Primates</subject><subject>proteins</subject><subject>RNA interference</subject><subject>Viral Proteins - metabolism</subject><subject>Virus Internalization</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS0EokPpC7BAXrLJcO34J0EIqRragtSqm9Kt5Tg3rUeeuNhJpb49jqZUsIGubF1_5-j6HELeMVgzYOrjdu0whDUHJspgDaBekBWDVleCaf6SrABaXjVKiwPyJuctADRSytfkgMtCFI8VOdvYXZyHYG-Q2rGnFz73PqGbfBw_0atbpKdzCNXlSI9ztnOYaBzoSReDpdc-zZl-9Rltxrfk1WBDxqPH85D8OD252nyrzi_Pvm-OzysnGz1VspHcdg441tp1newAGWv7mlvW2060qtwGUAwEirbuJWAvEcvafJC2BagPyZe9793c7bB3OE7JBnOX_M6mBxOtN3-_jP7W3MR7I7ioZc2KwYdHgxR_zpgns_N5ydGOGOdseEmJcwVK_xdlSgqltWD8GaioBTSgZUH5HnUp5pxweFqegVl6NVuzKM3S6zIrvRbR-z-__ST5XWQBPu8BLOHfe0wmO4-jw32bpo_-X_6_AL8gsmw</recordid><startdate>20141023</startdate><enddate>20141023</enddate><creator>Misasi, John</creator><creator>Sullivan, Nancy J.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20141023</creationdate><title>Camouflage and Misdirection: The Full-On Assault of Ebola Virus Disease</title><author>Misasi, John ; Sullivan, Nancy J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-5852abc02e37cbb5b0e119d32a1dab49632af06104e493d50ed5ee0852f5a9003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>antibodies</topic><topic>antigen presentation</topic><topic>cytokines</topic><topic>Cytokines - immunology</topic><topic>Ebola virus</topic><topic>Ebolavirus</topic><topic>Ebolavirus - physiology</topic><topic>fever</topic><topic>Hemorrhagic Fever, Ebola - immunology</topic><topic>Hemorrhagic Fever, Ebola - virology</topic><topic>hosts</topic><topic>humans</topic><topic>Immune Evasion</topic><topic>Immune Tolerance</topic><topic>Immunity, Humoral</topic><topic>interferon-gamma</topic><topic>Primates</topic><topic>proteins</topic><topic>RNA interference</topic><topic>Viral Proteins - metabolism</topic><topic>Virus Internalization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Misasi, John</creatorcontrib><creatorcontrib>Sullivan, Nancy J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Misasi, John</au><au>Sullivan, Nancy J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Camouflage and Misdirection: The Full-On Assault of Ebola Virus Disease</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2014-10-23</date><risdate>2014</risdate><volume>159</volume><issue>3</issue><spage>477</spage><epage>486</epage><pages>477-486</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Ebolaviruses cause a severe hemorrhagic fever syndrome that is rapidly fatal to humans and nonhuman primates. Ebola protein interactions with host cellular proteins disrupt type I and type II interferon responses, RNAi antiviral responses, antigen presentation, T-cell-dependent B cell responses, humoral antibodies, and cell-mediated immunity. This multifaceted approach to evasion and suppression of innate and adaptive immune responses in their target hosts leads to the severe immune dysregulation and “cytokine storm” that is characteristic of fatal ebolavirus infection. Here, we highlight some of the processes by which Ebola interacts with its mammalian hosts to evade antiviral defenses.
The current outbreak of Ebola warrants a detailed understanding of how members of this family of viruses suppress and evade host immune defenses and cause fatal hemorrhagic fever.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25417101</pmid><doi>10.1016/j.cell.2014.10.006</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0092-8674 |
| ispartof | Cell, 2014-10, Vol.159 (3), p.477-486 |
| issn | 0092-8674 1097-4172 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4243531 |
| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | antibodies antigen presentation cytokines Cytokines - immunology Ebola virus Ebolavirus Ebolavirus - physiology fever Hemorrhagic Fever, Ebola - immunology Hemorrhagic Fever, Ebola - virology hosts humans Immune Evasion Immune Tolerance Immunity, Humoral interferon-gamma Primates proteins RNA interference Viral Proteins - metabolism Virus Internalization |
| title | Camouflage and Misdirection: The Full-On Assault of Ebola Virus Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T04%3A22%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Camouflage%20and%20Misdirection:%20The%20Full-On%20Assault%20of%20Ebola%20Virus%20Disease&rft.jtitle=Cell&rft.au=Misasi,%20John&rft.date=2014-10-23&rft.volume=159&rft.issue=3&rft.spage=477&rft.epage=486&rft.pages=477-486&rft.issn=0092-8674&rft.eissn=1097-4172&rft_id=info:doi/10.1016/j.cell.2014.10.006&rft_dat=%3Cproquest_pubme%3E1654677412%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1643408075&rft_id=info:pmid/25417101&rft_els_id=S0092867414012938&rfr_iscdi=true |