Susceptibility to particle health effects, miRNA and exosomes: rationale and study protocol of the SPHERE study
Despite epidemiological findings showing increased air pollution related cardiovascular diseases (CVD), the knowledge of the involved molecular mechanisms remains moderate or weak. Particulate matter (PM) produces a local strong inflammatory reaction in the pulmonary environment but there is no fina...
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| creator | Bollati, Valentina Iodice, Simona Favero, Chiara Angelici, Laura Albetti, Benedetta Cacace, Raquel Cantone, Laura Carugno, Michele Cavalleri, Tommaso De Giorgio, Barbara Dioni, Laura Fustinoni, Silvia Hoxha, Mirjam Marinelli, Barbara Motta, Valeria Patrini, Lorenzo Pergoli, Laura Riboldi, Luciano Rizzo, Giovanna Rota, Federica Sucato, Sabrina Tarantini, Letizia Tirelli, Amedea Silvia Vigna, Luisella Bertazzi, Pieralberto Pesatori, Angela Cecilia |
| description | Despite epidemiological findings showing increased air pollution related cardiovascular diseases (CVD), the knowledge of the involved molecular mechanisms remains moderate or weak. Particulate matter (PM) produces a local strong inflammatory reaction in the pulmonary environment but there is no final evidence that PM physically enters and deposits in blood vessels. Extracellular vesicles (EVs) and their miRNA cargo might be the ideal candidate to mediate the effects of PM, since they could be potentially produced by the respiratory system, reach the systemic circulation and lead to the development of cardiovascular effects.The SPHERE ("Susceptibility to Particle Health Effects, miRNAs and Exosomes") project was granted by ERC-2011-StG 282413, to examine possible molecular mechanisms underlying the effects of PM exposure in relation to health outcomes.
The study population will include 2000 overweight (25 |
| doi_str_mv | 10.1186/1471-2458-14-1137 |
| format | Article |
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The study population will include 2000 overweight (25 < BMI < 30 kg/cm2) or obese (BMI ≥ 30 kg/cm2) subjects presenting at the Center for Obesity and Work (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy).Each subject donates blood, urine and hair samples. Extensive epidemiological and clinical data are collected. Exposure to PM is assigned to each subject using both daily PM10 concentration series from air quality monitors and pollutant levels estimated by the FARM (Flexible air Quality Regional Model) modelling system and elaborated by the Regional Environmental Protection Agency.The recruitment period started in September 2010 and will continue until 2015. At December 31, 2013 we recruited 1250 subjects, of whom 87% lived in the province of Milan.Primary study outcomes include cardiometabolic and respiratory health effects. The main molecular mechanism we are investigating focuses on EV-associated microRNAs.
SPHERE is the first large study aimed to explore EVs as a novel potential mechanism of how air pollution exposure acts in a highly susceptible population. The rigorous study design, the availability of banked biological samples and the potential to integrate epidemiological, clinical and molecular data will also furnish a powerful base for investigating different complementary molecular mechanisms. Our findings, if confirmed, could lead to the identification of potentially reversible alterations that might be considered as possible targets for new diagnostic and therapeutic interventions.</description><identifier>ISSN: 1471-2458</identifier><identifier>EISSN: 1471-2458</identifier><identifier>DOI: 10.1186/1471-2458-14-1137</identifier><identifier>PMID: 25371091</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Air Pollutants - analysis ; Air pollution ; Air Pollution - adverse effects ; Analysis ; Body mass index ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - urine ; Disease Susceptibility ; Environmental aspects ; Environmental Monitoring ; Epidemiology ; Exosomes - chemistry ; Female ; Gene expression ; Health aspects ; Humans ; Italy ; Laboratories ; Male ; MicroRNAs ; MicroRNAs - analysis ; Middle Aged ; Models, Theoretical ; Obesity ; Outdoor air quality ; Respiratory Tract Diseases - blood ; Respiratory Tract Diseases - etiology ; Respiratory Tract Diseases - urine ; Studies ; Study Protocol ; Urine</subject><ispartof>BMC public health, 2014-11, Vol.14 (1), p.1137-1137, Article 1137</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Bollati et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Bollati et al.; licensee BioMed Central Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b588t-92cf91c728ae3443c00f1ab68af9e6df51dc0ff82829edcb1ff015866d010fd83</citedby><cites>FETCH-LOGICAL-b588t-92cf91c728ae3443c00f1ab68af9e6df51dc0ff82829edcb1ff015866d010fd83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242553/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242553/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25371091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bollati, Valentina</creatorcontrib><creatorcontrib>Iodice, Simona</creatorcontrib><creatorcontrib>Favero, Chiara</creatorcontrib><creatorcontrib>Angelici, Laura</creatorcontrib><creatorcontrib>Albetti, Benedetta</creatorcontrib><creatorcontrib>Cacace, Raquel</creatorcontrib><creatorcontrib>Cantone, Laura</creatorcontrib><creatorcontrib>Carugno, Michele</creatorcontrib><creatorcontrib>Cavalleri, Tommaso</creatorcontrib><creatorcontrib>De Giorgio, Barbara</creatorcontrib><creatorcontrib>Dioni, Laura</creatorcontrib><creatorcontrib>Fustinoni, Silvia</creatorcontrib><creatorcontrib>Hoxha, Mirjam</creatorcontrib><creatorcontrib>Marinelli, Barbara</creatorcontrib><creatorcontrib>Motta, Valeria</creatorcontrib><creatorcontrib>Patrini, Lorenzo</creatorcontrib><creatorcontrib>Pergoli, Laura</creatorcontrib><creatorcontrib>Riboldi, Luciano</creatorcontrib><creatorcontrib>Rizzo, Giovanna</creatorcontrib><creatorcontrib>Rota, Federica</creatorcontrib><creatorcontrib>Sucato, Sabrina</creatorcontrib><creatorcontrib>Tarantini, Letizia</creatorcontrib><creatorcontrib>Tirelli, Amedea Silvia</creatorcontrib><creatorcontrib>Vigna, Luisella</creatorcontrib><creatorcontrib>Bertazzi, Pieralberto</creatorcontrib><creatorcontrib>Pesatori, Angela Cecilia</creatorcontrib><title>Susceptibility to particle health effects, miRNA and exosomes: rationale and study protocol of the SPHERE study</title><title>BMC public health</title><addtitle>BMC Public Health</addtitle><description>Despite epidemiological findings showing increased air pollution related cardiovascular diseases (CVD), the knowledge of the involved molecular mechanisms remains moderate or weak. Particulate matter (PM) produces a local strong inflammatory reaction in the pulmonary environment but there is no final evidence that PM physically enters and deposits in blood vessels. Extracellular vesicles (EVs) and their miRNA cargo might be the ideal candidate to mediate the effects of PM, since they could be potentially produced by the respiratory system, reach the systemic circulation and lead to the development of cardiovascular effects.The SPHERE ("Susceptibility to Particle Health Effects, miRNAs and Exosomes") project was granted by ERC-2011-StG 282413, to examine possible molecular mechanisms underlying the effects of PM exposure in relation to health outcomes.
The study population will include 2000 overweight (25 < BMI < 30 kg/cm2) or obese (BMI ≥ 30 kg/cm2) subjects presenting at the Center for Obesity and Work (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy).Each subject donates blood, urine and hair samples. Extensive epidemiological and clinical data are collected. Exposure to PM is assigned to each subject using both daily PM10 concentration series from air quality monitors and pollutant levels estimated by the FARM (Flexible air Quality Regional Model) modelling system and elaborated by the Regional Environmental Protection Agency.The recruitment period started in September 2010 and will continue until 2015. At December 31, 2013 we recruited 1250 subjects, of whom 87% lived in the province of Milan.Primary study outcomes include cardiometabolic and respiratory health effects. The main molecular mechanism we are investigating focuses on EV-associated microRNAs.
SPHERE is the first large study aimed to explore EVs as a novel potential mechanism of how air pollution exposure acts in a highly susceptible population. The rigorous study design, the availability of banked biological samples and the potential to integrate epidemiological, clinical and molecular data will also furnish a powerful base for investigating different complementary molecular mechanisms. Our findings, if confirmed, could lead to the identification of potentially reversible alterations that might be considered as possible targets for new diagnostic and therapeutic interventions.</description><subject>Air Pollutants - analysis</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Analysis</subject><subject>Body mass index</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - urine</subject><subject>Disease Susceptibility</subject><subject>Environmental aspects</subject><subject>Environmental Monitoring</subject><subject>Epidemiology</subject><subject>Exosomes - chemistry</subject><subject>Female</subject><subject>Gene expression</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Italy</subject><subject>Laboratories</subject><subject>Male</subject><subject>MicroRNAs</subject><subject>MicroRNAs - analysis</subject><subject>Middle Aged</subject><subject>Models, Theoretical</subject><subject>Obesity</subject><subject>Outdoor air quality</subject><subject>Respiratory Tract Diseases - blood</subject><subject>Respiratory Tract Diseases - etiology</subject><subject>Respiratory Tract Diseases - urine</subject><subject>Studies</subject><subject>Study Protocol</subject><subject>Urine</subject><issn>1471-2458</issn><issn>1471-2458</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk1v1DAQhiMEoh_wA7ggS1w4NMVjx4nNAWlVFopUAWrhbDmO3XWVxIvtIPbf47Bl6aIiIR88mnnm1eidKYpngE8BeP0KqgZKUjFeQlUC0OZBcbjLPbwTHxRHMd5gDA1n5HFxQBhtAAs4LPzVFLVZJ9e63qUNSh6tVUhO9watjOrTChlrjU7xBA3u8uMCqbFD5oePfjDxNQoqOT-qTM_5mKZug9bBJ699j7xFaWXQ1efz5eVyW3xSPLKqj-bp7X9cfH23_HJ2Xl58ev_hbHFRtozzVAqirQDdEK4MrSqqMbag2porK0zdWQadxtZywokwnW7BWgyM13WHAduO0-PizVZ3PbVDJsyYgurlOrhBhY30ysn9yuhW8tp_lxWpCGM0C7zdCrTO_0Ngv6L9IGfD5Wx4juS8kCzz8naO4L9NJiY5uGx436vR-ClKqCnDlIha_AdKGsEYx7Pqi7_QGz-FvIZfVM25EAL_oa7zfqQbrc-D6llULhgVTNRQkUyd3kPl15nBaT8a63J-rwG2DTr4GIOxO1MAy_ku77Xh-d117Dp-HyL9CQNv3WQ</recordid><startdate>20141104</startdate><enddate>20141104</enddate><creator>Bollati, Valentina</creator><creator>Iodice, Simona</creator><creator>Favero, Chiara</creator><creator>Angelici, Laura</creator><creator>Albetti, Benedetta</creator><creator>Cacace, Raquel</creator><creator>Cantone, Laura</creator><creator>Carugno, Michele</creator><creator>Cavalleri, Tommaso</creator><creator>De Giorgio, Barbara</creator><creator>Dioni, Laura</creator><creator>Fustinoni, Silvia</creator><creator>Hoxha, Mirjam</creator><creator>Marinelli, Barbara</creator><creator>Motta, Valeria</creator><creator>Patrini, Lorenzo</creator><creator>Pergoli, Laura</creator><creator>Riboldi, Luciano</creator><creator>Rizzo, Giovanna</creator><creator>Rota, Federica</creator><creator>Sucato, Sabrina</creator><creator>Tarantini, Letizia</creator><creator>Tirelli, Amedea Silvia</creator><creator>Vigna, Luisella</creator><creator>Bertazzi, Pieralberto</creator><creator>Pesatori, Angela Cecilia</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7X8</scope><scope>7TV</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>20141104</creationdate><title>Susceptibility to particle health effects, miRNA and exosomes: rationale and study protocol of the SPHERE study</title><author>Bollati, Valentina ; Iodice, Simona ; Favero, Chiara ; Angelici, Laura ; Albetti, Benedetta ; Cacace, Raquel ; Cantone, Laura ; Carugno, Michele ; Cavalleri, Tommaso ; De Giorgio, Barbara ; Dioni, Laura ; Fustinoni, Silvia ; Hoxha, Mirjam ; Marinelli, Barbara ; Motta, Valeria ; Patrini, Lorenzo ; Pergoli, Laura ; Riboldi, Luciano ; Rizzo, Giovanna ; Rota, Federica ; Sucato, Sabrina ; Tarantini, Letizia ; Tirelli, Amedea Silvia ; Vigna, Luisella ; Bertazzi, Pieralberto ; Pesatori, Angela Cecilia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b588t-92cf91c728ae3443c00f1ab68af9e6df51dc0ff82829edcb1ff015866d010fd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Air Pollutants - 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Particulate matter (PM) produces a local strong inflammatory reaction in the pulmonary environment but there is no final evidence that PM physically enters and deposits in blood vessels. Extracellular vesicles (EVs) and their miRNA cargo might be the ideal candidate to mediate the effects of PM, since they could be potentially produced by the respiratory system, reach the systemic circulation and lead to the development of cardiovascular effects.The SPHERE ("Susceptibility to Particle Health Effects, miRNAs and Exosomes") project was granted by ERC-2011-StG 282413, to examine possible molecular mechanisms underlying the effects of PM exposure in relation to health outcomes.
The study population will include 2000 overweight (25 < BMI < 30 kg/cm2) or obese (BMI ≥ 30 kg/cm2) subjects presenting at the Center for Obesity and Work (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy).Each subject donates blood, urine and hair samples. Extensive epidemiological and clinical data are collected. Exposure to PM is assigned to each subject using both daily PM10 concentration series from air quality monitors and pollutant levels estimated by the FARM (Flexible air Quality Regional Model) modelling system and elaborated by the Regional Environmental Protection Agency.The recruitment period started in September 2010 and will continue until 2015. At December 31, 2013 we recruited 1250 subjects, of whom 87% lived in the province of Milan.Primary study outcomes include cardiometabolic and respiratory health effects. The main molecular mechanism we are investigating focuses on EV-associated microRNAs.
SPHERE is the first large study aimed to explore EVs as a novel potential mechanism of how air pollution exposure acts in a highly susceptible population. The rigorous study design, the availability of banked biological samples and the potential to integrate epidemiological, clinical and molecular data will also furnish a powerful base for investigating different complementary molecular mechanisms. Our findings, if confirmed, could lead to the identification of potentially reversible alterations that might be considered as possible targets for new diagnostic and therapeutic interventions.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25371091</pmid><doi>10.1186/1471-2458-14-1137</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1471-2458 |
| ispartof | BMC public health, 2014-11, Vol.14 (1), p.1137-1137, Article 1137 |
| issn | 1471-2458 1471-2458 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4242553 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Air Pollutants - analysis Air pollution Air Pollution - adverse effects Analysis Body mass index Cardiovascular Diseases - blood Cardiovascular Diseases - etiology Cardiovascular Diseases - urine Disease Susceptibility Environmental aspects Environmental Monitoring Epidemiology Exosomes - chemistry Female Gene expression Health aspects Humans Italy Laboratories Male MicroRNAs MicroRNAs - analysis Middle Aged Models, Theoretical Obesity Outdoor air quality Respiratory Tract Diseases - blood Respiratory Tract Diseases - etiology Respiratory Tract Diseases - urine Studies Study Protocol Urine |
| title | Susceptibility to particle health effects, miRNA and exosomes: rationale and study protocol of the SPHERE study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T05%3A49%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Susceptibility%20to%20particle%20health%20effects,%20miRNA%20and%20exosomes:%20rationale%20and%20study%20protocol%20of%20the%20SPHERE%20study&rft.jtitle=BMC%20public%20health&rft.au=Bollati,%20Valentina&rft.date=2014-11-04&rft.volume=14&rft.issue=1&rft.spage=1137&rft.epage=1137&rft.pages=1137-1137&rft.artnum=1137&rft.issn=1471-2458&rft.eissn=1471-2458&rft_id=info:doi/10.1186/1471-2458-14-1137&rft_dat=%3Cgale_pubme%3EA539596142%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1626889990&rft_id=info:pmid/25371091&rft_galeid=A539596142&rfr_iscdi=true |