Inhibition of parathyroid hormone secretion and parathyroid hormone-independent diminution of tubular calcium reabsorption by WR-2721, a unique hypocalcemic agent

Hypocalcemia has been observed in patients receiving WR-2721 [S-,2-(3-aminopropylamino)-, ethylphosphorothioic acid]. WR-2721 is a compound that, after being dephosphorylated, provides protection of normal tissues against radio- and chemotherapy. The hypocalcemic response was accompanied by a decrea...

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Veröffentlicht in:	The Journal of clinical investigation 1985-11, Vol.76 (5), p.1851-1856
Hauptverfasser:	HIRSCHEL-SCHOLZ, S, CAVERZASIO, J, BONJOUR, J.-P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amifostine - pharmacology Animals Biological and medical sciences Calcium - blood Calcium - metabolism Cyclic AMP - urine Hormones. Endocrine system Hyperparathyroidism - drug therapy Kidney Tubules - drug effects Kidney Tubules - metabolism Magnesium - blood Male Medical sciences Organothiophosphorus Compounds - pharmacology Parathyroid Glands - physiology Parathyroid Hormone - secretion Pharmacology. Drug treatments Phosphorylation Rats Secretory Rate - drug effects Structure-Activity Relationship
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