Low Piconewton Towing of CNS Axons against Diffusing and Surface-Bound Repellents Requires the Inhibition of Motor Protein-Associated Pathways

Growth cones, dynamic structures at axon tips, integrate chemical and physical stimuli and translate them into coordinated axon behaviour, e.g. , elongation or turning. External force application to growth cones directs and enhances axon elongation in vitro ; however, direct mechanical stimulation i...

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Veröffentlicht in:	Scientific reports 2014-11, Vol.4 (1), p.7128-7128, Article 7128
Hauptverfasser:	Kilinc, Devrim, Blasiak, Agata, O'Mahony, James J., Lee, Gil U.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/62 14/1 14/34 14/63 631/1647/2204/2209 631/1647/277 631/378/2571/2576 639/166/985 Amides - pharmacology Animals Axon guidance Axons Axons - drug effects Axons - physiology Cell adhesion & migration Cell adhesion molecules Cells, Cultured Central nervous system Central Nervous System - metabolism Chondroitin sulfate Chondroitin Sulfates - chemistry Chondroitin Sulfates - metabolism Contractility Cortex Diffusion Elongation Enzyme inhibitors Growth cones Humanities and Social Sciences Kinesin Mechanical stimuli Mice Microfluidic Analytical Techniques Microfluidics Models, Biological Molecular Motor Proteins - antagonists & inhibitors Molecular Motor Proteins - metabolism Motor task performance multidisciplinary Neurons - cytology Proteoglycans Pyridines - pharmacology Repellents rhoA GTP-Binding Protein - antagonists & inhibitors rhoA GTP-Binding Protein - metabolism RhoA protein Science Semaphorin-3A - metabolism Sulfates
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