Fractal Globules: A New Approach to Artificial Molecular Machines
The over-damped relaxation of elastic networks constructed by contact maps of hierarchically folded fractal (crumpled) polymer globules was investigated in detail. It was found that the relaxation dynamics of an anisotropic fractal globule is very similar to the behavior of biological molecular mach...
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| Veröffentlicht in: | Biophysical journal 2014-11, Vol.107 (10), p.2361-2368 |
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| container_title | Biophysical journal |
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| creator | Avetisov, Vladik A. Ivanov, Viktor A. Meshkov, Dmitry A. Nechaev, Sergei K. |
| description | The over-damped relaxation of elastic networks constructed by contact maps of hierarchically folded fractal (crumpled) polymer globules was investigated in detail. It was found that the relaxation dynamics of an anisotropic fractal globule is very similar to the behavior of biological molecular machines like motor proteins. When it is perturbed, the system quickly relaxes to a low-dimensional manifold, M, with a large basin of attraction and then slowly approaches equilibrium, not escaping M. Taking these properties into account, it is suggested that fractal globules, even those made by synthetic polymers, are artificial molecular machines that can transform perturbations into directed quasimechanical motion along a defined path. |
| doi_str_mv | 10.1016/j.bpj.2014.10.019 |
| format | Article |
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It was found that the relaxation dynamics of an anisotropic fractal globule is very similar to the behavior of biological molecular machines like motor proteins. When it is perturbed, the system quickly relaxes to a low-dimensional manifold, M, with a large basin of attraction and then slowly approaches equilibrium, not escaping M. 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Taking these properties into account, it is suggested that fractal globules, even those made by synthetic polymers, are artificial molecular machines that can transform perturbations into directed quasimechanical motion along a defined path.</description><subject>Anisotropy</subject><subject>Biomimetics</subject><subject>Biophysics</subject><subject>Biopolymers</subject><subject>Dynamical systems</subject><subject>Dynamics</subject><subject>Elasticity</subject><subject>Equilibrium</subject><subject>Fractal analysis</subject><subject>Fractals</subject><subject>Globules</subject><subject>Models, Molecular</subject><subject>Molecular biology</subject><subject>Molecular Conformation</subject><subject>Molecular machines</subject><subject>Molecular Machines, Motors and Nanoscale Biophysics</subject><subject>Molecular Motor Proteins - metabolism</subject><subject>Networks</subject><subject>Polymers - chemistry</subject><subject>Proteins</subject><issn>0006-3495</issn><issn>1542-0086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi1ERZfCA3BBkbhwyXbs2E4MUqWoogWphQucLceZUEfeONhJEW-PV1sq4FD1ZNnzza_xfIS8orClQOXpuO3mccuA8nzfAlVPyIYKzkqARj4lGwCQZcWVOCbPUxoBKBNAn5FjJjhtKhAb0l5EYxfji0sfutVjele0xWf8WbTzHIOxN8USijYubnDWZew6eLSrN7G4zkU3YXpBjgbjE768O0_It4sPX88_lldfLj-dt1elFXWzlMaqzrBBSaFQ1hw6amwvBIWGCSGtkdRywQAN9gOI3oBAalnHZVcZMfR9dULODrnz2u2wtzgt0Xg9R7cz8ZcOxul_K5O70d_DreaMUy5kDnh7FxDDjxXToncuWfTeTBjWpKmUqpFQ1_UjUFarhikuMvrmP3QMa5zyJjJV1bJSWUKm6IGyMaQUcbifm4Leu9Sjzi713uX-KbvMPa___vB9xx95GXh_ADCv_dZh1Mk6nCz2LqJddB_cA_G_AUaGriM</recordid><startdate>20141118</startdate><enddate>20141118</enddate><creator>Avetisov, Vladik A.</creator><creator>Ivanov, Viktor A.</creator><creator>Meshkov, Dmitry A.</creator><creator>Nechaev, Sergei K.</creator><general>Elsevier Inc</general><general>Biophysical Society</general><general>The Biophysical Society</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>7TB</scope><scope>7U5</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20141118</creationdate><title>Fractal Globules: A New Approach to Artificial Molecular Machines</title><author>Avetisov, Vladik A. ; 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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Anisotropy Biomimetics Biophysics Biopolymers Dynamical systems Dynamics Elasticity Equilibrium Fractal analysis Fractals Globules Models, Molecular Molecular biology Molecular Conformation Molecular machines Molecular Machines, Motors and Nanoscale Biophysics Molecular Motor Proteins - metabolism Networks Polymers - chemistry Proteins |
| title | Fractal Globules: A New Approach to Artificial Molecular Machines |
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