Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability
Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing (RAP), visual attention and working memory. Genetic variants in Doublecortin domain‐contain...
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| Veröffentlicht in: | Genes, brain and behavior brain and behavior, 2014-11, Vol.13 (8), p.802-811 |
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| creator | Truong, D. T. Che, A. Rendall, A. R. Szalkowski, C. E. LoTurco, J. J. Galaburda, A. M. Holly Fitch, R. |
| description | Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing (RAP), visual attention and working memory. Genetic variants in Doublecortin domain‐containing protein 2 (DCDC2) have been associated with dyslexia, impairments in phonological processing and in short‐term/working memory. The purpose of this study was to determine whether sensory and behavioral impairments can result directly from mutation of the Dcdc2 gene in mice. Several behavioral tasks, including a modified pre‐pulse inhibition paradigm (to examine auditory processing), a 4/8 radial arm maze (to assess/dissociate working vs. reference memory) and rotarod (to examine sensorimotor ability and motor learning), were used to assess the effects of Dcdc2 mutation. Behavioral results revealed deficits in RAP, working memory and reference memory in Dcdc2del2/del2 mice when compared with matched wild types. Current findings parallel clinical research linking genetic variants of DCDC2 with specific impairments of phonological processing and memory ability.
Dcdc2 mutant mice show impaired working and reference memory performance on a 4/8 radial arm water maze. |
| doi_str_mv | 10.1111/gbb.12170 |
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Dcdc2 mutant mice show impaired working and reference memory performance on a 4/8 radial arm water maze.</description><identifier>ISSN: 1601-1848</identifier><identifier>EISSN: 1601-183X</identifier><identifier>DOI: 10.1111/gbb.12170</identifier><identifier>PMID: 25130614</identifier><identifier>CODEN: GBBEAO</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Auditory Perception - genetics ; Auditory Perceptual Disorders - genetics ; Behavior, Animal - physiology ; Brain ; Children & youth ; Dcdc2 ; Dyslexia ; language impairment ; Male ; Maze Learning - physiology ; Memory - physiology ; Mice ; Mice, Knockout ; Microtubule-Associated Proteins - genetics ; Motor Skills - physiology ; Mutation ; Phonetics ; rapid auditory processing ; Rotarod Performance Test ; working memory</subject><ispartof>Genes, brain and behavior, 2014-11, Vol.13 (8), p.802-811</ispartof><rights>2014 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society</rights><rights>2014 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5790-ded5aa7eb2c48ec96e9e6e35c8dba255afef89584f295ef5d1841e2e35b9a73c3</citedby><cites>FETCH-LOGICAL-c5790-ded5aa7eb2c48ec96e9e6e35c8dba255afef89584f295ef5d1841e2e35b9a73c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fgbb.12170$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fgbb.12170$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fgbb.12170$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25130614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Truong, D. T.</creatorcontrib><creatorcontrib>Che, A.</creatorcontrib><creatorcontrib>Rendall, A. R.</creatorcontrib><creatorcontrib>Szalkowski, C. E.</creatorcontrib><creatorcontrib>LoTurco, J. J.</creatorcontrib><creatorcontrib>Galaburda, A. M.</creatorcontrib><creatorcontrib>Holly Fitch, R.</creatorcontrib><title>Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability</title><title>Genes, brain and behavior</title><addtitle>Genes Brain Behav</addtitle><description>Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing (RAP), visual attention and working memory. Genetic variants in Doublecortin domain‐containing protein 2 (DCDC2) have been associated with dyslexia, impairments in phonological processing and in short‐term/working memory. The purpose of this study was to determine whether sensory and behavioral impairments can result directly from mutation of the Dcdc2 gene in mice. Several behavioral tasks, including a modified pre‐pulse inhibition paradigm (to examine auditory processing), a 4/8 radial arm maze (to assess/dissociate working vs. reference memory) and rotarod (to examine sensorimotor ability and motor learning), were used to assess the effects of Dcdc2 mutation. Behavioral results revealed deficits in RAP, working memory and reference memory in Dcdc2del2/del2 mice when compared with matched wild types. Current findings parallel clinical research linking genetic variants of DCDC2 with specific impairments of phonological processing and memory ability.
Dcdc2 mutant mice show impaired working and reference memory performance on a 4/8 radial arm water maze.</description><subject>Animals</subject><subject>Auditory Perception - genetics</subject><subject>Auditory Perceptual Disorders - genetics</subject><subject>Behavior, Animal - physiology</subject><subject>Brain</subject><subject>Children & youth</subject><subject>Dcdc2</subject><subject>Dyslexia</subject><subject>language impairment</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Memory - physiology</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Microtubule-Associated Proteins - genetics</subject><subject>Motor Skills - physiology</subject><subject>Mutation</subject><subject>Phonetics</subject><subject>rapid auditory processing</subject><subject>Rotarod Performance Test</subject><subject>working memory</subject><issn>1601-1848</issn><issn>1601-183X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFLHDEUx0NRqtUe-gUk4KU9rOZlJpnMpeDaVgWLlxa8hUzyZo3MTLbJTMt--2a7uqggNJeE9378eC9_Qj4AO4F8ThdNcwIcKvaG7INkMANV3O5s36XaI-9SumcMqkLBW7LHBRRMQrlPbr9Poxl9GGho6RfrLKd-oL23SDs0LtExUN8vjY89DmNaN83k_Bjiii5jsJiSHxbUDI722K-rpvGdH1eHZLc1XcL3D_cB-fnt64_zy9n1zcXV-dn1zIqqZjOHThhTYcNtqdDWEmuUWAirXGO4EKbFVtVClS2vBbbC5XUAeSaa2lSFLQ7I5413OTU9OpunjKbTy-h7E1c6GK-fdwZ_pxfhty55CSBVFnx8EMTwa8I06t4ni11nBgxT0iALwUomJfsPlFesglrIjB6_QO_DFIf8E2tKVqAymalPG8rGkFLEdjs3ML2OVudo9b9oM3v0dNEt-ZhlBk43wB_f4ep1k76YzzfKv4d7ric</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Truong, D. T.</creator><creator>Che, A.</creator><creator>Rendall, A. R.</creator><creator>Szalkowski, C. E.</creator><creator>LoTurco, J. J.</creator><creator>Galaburda, A. M.</creator><creator>Holly Fitch, R.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201411</creationdate><title>Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability</title><author>Truong, D. T. ; Che, A. ; Rendall, A. R. ; Szalkowski, C. E. ; LoTurco, J. J. ; Galaburda, A. M. ; Holly Fitch, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5790-ded5aa7eb2c48ec96e9e6e35c8dba255afef89584f295ef5d1841e2e35b9a73c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Auditory Perception - genetics</topic><topic>Auditory Perceptual Disorders - genetics</topic><topic>Behavior, Animal - physiology</topic><topic>Brain</topic><topic>Children & youth</topic><topic>Dcdc2</topic><topic>Dyslexia</topic><topic>language impairment</topic><topic>Male</topic><topic>Maze Learning - physiology</topic><topic>Memory - physiology</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Microtubule-Associated Proteins - genetics</topic><topic>Motor Skills - physiology</topic><topic>Mutation</topic><topic>Phonetics</topic><topic>rapid auditory processing</topic><topic>Rotarod Performance Test</topic><topic>working memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Truong, D. T.</creatorcontrib><creatorcontrib>Che, A.</creatorcontrib><creatorcontrib>Rendall, A. R.</creatorcontrib><creatorcontrib>Szalkowski, C. E.</creatorcontrib><creatorcontrib>LoTurco, J. J.</creatorcontrib><creatorcontrib>Galaburda, A. M.</creatorcontrib><creatorcontrib>Holly Fitch, R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes, brain and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Truong, D. T.</au><au>Che, A.</au><au>Rendall, A. R.</au><au>Szalkowski, C. E.</au><au>LoTurco, J. J.</au><au>Galaburda, A. M.</au><au>Holly Fitch, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability</atitle><jtitle>Genes, brain and behavior</jtitle><addtitle>Genes Brain Behav</addtitle><date>2014-11</date><risdate>2014</risdate><volume>13</volume><issue>8</issue><spage>802</spage><epage>811</epage><pages>802-811</pages><issn>1601-1848</issn><eissn>1601-183X</eissn><coden>GBBEAO</coden><abstract>Dyslexia is a complex neurodevelopmental disorder characterized by impaired reading ability despite normal intellect, and is associated with specific difficulties in phonological and rapid auditory processing (RAP), visual attention and working memory. Genetic variants in Doublecortin domain‐containing protein 2 (DCDC2) have been associated with dyslexia, impairments in phonological processing and in short‐term/working memory. The purpose of this study was to determine whether sensory and behavioral impairments can result directly from mutation of the Dcdc2 gene in mice. Several behavioral tasks, including a modified pre‐pulse inhibition paradigm (to examine auditory processing), a 4/8 radial arm maze (to assess/dissociate working vs. reference memory) and rotarod (to examine sensorimotor ability and motor learning), were used to assess the effects of Dcdc2 mutation. Behavioral results revealed deficits in RAP, working memory and reference memory in Dcdc2del2/del2 mice when compared with matched wild types. Current findings parallel clinical research linking genetic variants of DCDC2 with specific impairments of phonological processing and memory ability.
Dcdc2 mutant mice show impaired working and reference memory performance on a 4/8 radial arm water maze.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>25130614</pmid><doi>10.1111/gbb.12170</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Auditory Perception - genetics Auditory Perceptual Disorders - genetics Behavior, Animal - physiology Brain Children & youth Dcdc2 Dyslexia language impairment Male Maze Learning - physiology Memory - physiology Mice Mice, Knockout Microtubule-Associated Proteins - genetics Motor Skills - physiology Mutation Phonetics rapid auditory processing Rotarod Performance Test working memory |
| title | Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability |
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