A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons

Parkinson's disease (PD), the most common degenerative movement disorder, is caused by a preferential loss of midbrain dopaminergic (mDA) neurons. Both α-synuclein (α-syn) missense and multiplication mutations have been linked to PD. However, the underlying intracellular signalling transduction...

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Veröffentlicht in:	Human molecular genetics 2014-12, Vol.23 (24), p.6567-6574
Hauptverfasser:	Luo, Jing, Sun, Lixin, Lin, Xian, Liu, Guoxiang, Yu, Jia, Parisiadou, Loukia, Xie, Chengsong, Ding, Jinhui, Cai, Huaibin
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - genetics alpha-Synuclein - metabolism Animals Apoptosis - drug effects Calcineurin - genetics Calcineurin - metabolism Calcineurin Inhibitors - pharmacology Cyclosporine - pharmacology Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Gene Expression Regulation HEK293 Cells Humans Mesencephalon - drug effects Mesencephalon - metabolism Mesencephalon - pathology Mice Mice, Transgenic Mutation NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism Parkinson Disease - drug therapy Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - pathology Primary Cell Culture Signal Transduction
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