Lubiprostone vs Senna in postoperative orthopedic surgery patients with opioid-induced constipation:A double-blind,active-comparator trial

AIM:To investigate the efficacy of lubiprostone compared to Senna on bowel symptoms and constipation in post-operative orthopedic patients treated with opioids.METHODS:In this double blind,randomized,active comparator trial,adults who required opioids for analgesia following orthopedic procedures an...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2014-11, Vol.20 (43), p.16323-16333
Hauptverfasser:	Marciniak, Christina M, Toledo, Santiago, Lee, Jungwha, Jesselson, Michael, Bateman, Jillian, Grover, Benjamin, Tierny, Joy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alprostadil - analogs & derivatives Alprostadil - therapeutic use Analgesics, Opioid - adverse effects Cathartics - therapeutic use Chicago Constipation Constipation - chemically induced Constipation - diagnosis Constipation - drug therapy Constipation - physiopathology Defecation - drug effects Double-Blind Method Female Humans Lubiprostone Male Middle Aged Opioids Orthopedic Orthopedic Procedures - adverse effects Pain, Postoperative - diagnosis Pain, Postoperative - etiology Pain, Postoperative - prevention & control Quality of Life Randomized Clinical Trial Recovery of Function Senna Senna Extract - therapeutic use Surveys and Questionnaires Time Factors Treatment Outcome
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