Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome
AIM:To investigate the effects of a low fermentable,oligosaccharides,disaccharides,monosaccharides and polyols diet(LFD)and the probiotic Lactobacillus rhamnosus GG(LGG)in irritable bowel syndrome(IBS).METHODS:Randomised,unblinded controlled trial on the effect of 6-wk treatment with LFD,LGG or a no...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2014-11, Vol.20 (43), p.16215-16226 |
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| creator | Pedersen, Natalia Andersen, Nynne Nyboe Végh, Zsuzsanna Jensen, Lisbeth Ankersen, Dorit Vedel Felding, Maria Simonsen, Mette Hestetun Burisch, Johan Munkholm, Pia |
| description | AIM:To investigate the effects of a low fermentable,oligosaccharides,disaccharides,monosaccharides and polyols diet(LFD)and the probiotic Lactobacillus rhamnosus GG(LGG)in irritable bowel syndrome(IBS).METHODS:Randomised,unblinded controlled trial on the effect of 6-wk treatment with LFD,LGG or a normal Danish/Western diet(ND)in patients with IBS fulfilling Rome III diagnostic criteria,recruited betweenNovember 2009 and April 2013.Patients were required to complete on a weekly basis the IBS severity score system(IBS-SSS)and IBS quality of life(IBS-QOL)questionnaires in a specially developed IBS web selfmonitoring application.We investigated whether LFD or LGG could reduce IBS-SSS and improve QOL in IBS patients.RESULTS:One hundred twenty-three(median age 37years,range:18-74 years),90(73%)females were randomised:42 to LFD,41 to LGG and 40 to ND.A significant reduction in mean±SD of IBS-SSS from baseline to week 6 between LFD vs LGG vs ND was revealed:133±122 vs 68±107,133±122 vs 34±95,P<0.01.Adjusted changes of IBS-SSS for baseline covariates showed statistically significant reduction of IBS-SSS in LFD group compared to ND(IBS-SSS score75;95%CI:24-126,P<0.01),but not in LGG compared to ND(IBS-SSS score 32;95%CI:18-80,P=0.20).IBS-QOL was not altered significantly in any of the three groups:mean±SD in LFD 8±18 vs LGG 7±17,LFD 8±18 vs ND 0.1±15,P=0.13.CONCLUSION:LFD is efficacious for patients with IBS. |
| doi_str_mv | 10.3748/wjg.v20.i43.16215 |
| format | Article |
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All rights reserved. 2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-8bfcc42a9c8804b25dc3031b0d95c367d88930cee8472705295f3923eb1457a63</citedby><cites>FETCH-LOGICAL-c400t-8bfcc42a9c8804b25dc3031b0d95c367d88930cee8472705295f3923eb1457a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239510/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239510/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25473176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pedersen, Natalia</creatorcontrib><creatorcontrib>Andersen, Nynne Nyboe</creatorcontrib><creatorcontrib>Végh, Zsuzsanna</creatorcontrib><creatorcontrib>Jensen, Lisbeth</creatorcontrib><creatorcontrib>Ankersen, Dorit Vedel</creatorcontrib><creatorcontrib>Felding, Maria</creatorcontrib><creatorcontrib>Simonsen, Mette Hestetun</creatorcontrib><creatorcontrib>Burisch, Johan</creatorcontrib><creatorcontrib>Munkholm, Pia</creatorcontrib><title>Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM:To investigate the effects of a low fermentable,oligosaccharides,disaccharides,monosaccharides and polyols diet(LFD)and the probiotic Lactobacillus rhamnosus GG(LGG)in irritable bowel syndrome(IBS).METHODS:Randomised,unblinded controlled trial on the effect of 6-wk treatment with LFD,LGG or a normal Danish/Western diet(ND)in patients with IBS fulfilling Rome III diagnostic criteria,recruited betweenNovember 2009 and April 2013.Patients were required to complete on a weekly basis the IBS severity score system(IBS-SSS)and IBS quality of life(IBS-QOL)questionnaires in a specially developed IBS web selfmonitoring application.We investigated whether LFD or LGG could reduce IBS-SSS and improve QOL in IBS patients.RESULTS:One hundred twenty-three(median age 37years,range:18-74 years),90(73%)females were randomised:42 to LFD,41 to LGG and 40 to ND.A significant reduction in mean±SD of IBS-SSS from baseline to week 6 between LFD vs LGG vs ND was revealed:133±122 vs 68±107,133±122 vs 34±95,P&lt;0.01.Adjusted changes of IBS-SSS for baseline covariates showed statistically significant reduction of IBS-SSS in LFD group compared to ND(IBS-SSS score75;95%CI:24-126,P&lt;0.01),but not in LGG compared to ND(IBS-SSS score 32;95%CI:18-80,P=0.20).IBS-QOL was not altered significantly in any of the three groups:mean±SD in LFD 8±18 vs LGG 7±17,LFD 8±18 vs ND 0.1±15,P=0.13.CONCLUSION:LFD is efficacious for patients with IBS.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>bowel</subject><subject>Denmark</subject><subject>Diet, Carbohydrate-Restricted</subject><subject>Dietary Carbohydrates - metabolism</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Fermentation</subject><subject>Humans</subject><subject>Internet</subject><subject>Irritable</subject><subject>Irritable Bowel Syndrome - diagnosis</subject><subject>Irritable Bowel Syndrome - diet therapy</subject><subject>Irritable Bowel Syndrome - metabolism</subject><subject>Irritable Bowel Syndrome - microbiology</subject><subject>Lactobacillus rhamnosus - physiology</subject><subject>Low</subject><subject>Male</subject><subject>management</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Patient Dropouts</subject><subject>Probiotics - therapeutic use</subject><subject>Quality of Life</subject><subject>Severity of Illness Index</subject><subject>Surveys and Questionnaires</subject><subject>syndrome</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Web-based</subject><subject>Young Adult</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1rGzEQhkVpaZy0P6CXssde1hl9raQeCiFNnIBLWmjPQquVvQraVSKtbfLvKyeuSUcMI5h3Xol5EPqEYU4Fk-e7-_V8S2DuGZ3jhmD-Bs0IwaomksFbNMMAolaUiBN0mvM9AKGUk_fohHAmKBbNDP266p0JU_91GXfV9d33Hxc_q867qdrmamnsFFtjfQibXKXeDGPM5bZYVH6sfEp-Mm1wVRt3LlT5aexSHNwH9G5lQnYfD_UM_bm--n15Uy_vFreXF8vaMoCplu3KWkaMslICawnvLAWKW-gUt7QRnZSKgnVOMkEEcKL4iipCXYsZF6ahZ-jbi-_Dph1cZ904JRP0Q_KDSU86Gq__74y-1-u41YxQxTEUgy8HgxQfNy5PevDZuhDM6OIma9xQRgRtpChS_CK1Keac3Or4DAa9R6ELCl1Q6IJCP6MoM59f_-848W_3RUAPpn0c149-XB81CuQ-FAcmmeKkHMzkPulfftmVDg</recordid><startdate>20141121</startdate><enddate>20141121</enddate><creator>Pedersen, Natalia</creator><creator>Andersen, Nynne Nyboe</creator><creator>Végh, Zsuzsanna</creator><creator>Jensen, Lisbeth</creator><creator>Ankersen, Dorit Vedel</creator><creator>Felding, Maria</creator><creator>Simonsen, Mette Hestetun</creator><creator>Burisch, Johan</creator><creator>Munkholm, Pia</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141121</creationdate><title>Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome</title><author>Pedersen, Natalia ; Andersen, Nynne Nyboe ; Végh, Zsuzsanna ; Jensen, Lisbeth ; Ankersen, Dorit Vedel ; Felding, Maria ; Simonsen, Mette Hestetun ; Burisch, Johan ; Munkholm, Pia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-8bfcc42a9c8804b25dc3031b0d95c367d88930cee8472705295f3923eb1457a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>bowel</topic><topic>Denmark</topic><topic>Diet, Carbohydrate-Restricted</topic><topic>Dietary Carbohydrates - metabolism</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Fermentation</topic><topic>Humans</topic><topic>Internet</topic><topic>Irritable</topic><topic>Irritable Bowel Syndrome - diagnosis</topic><topic>Irritable Bowel Syndrome - diet therapy</topic><topic>Irritable Bowel Syndrome - metabolism</topic><topic>Irritable Bowel Syndrome - microbiology</topic><topic>Lactobacillus rhamnosus - physiology</topic><topic>Low</topic><topic>Male</topic><topic>management</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Patient Dropouts</topic><topic>Probiotics - therapeutic use</topic><topic>Quality of Life</topic><topic>Severity of Illness Index</topic><topic>Surveys and Questionnaires</topic><topic>syndrome</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Web-based</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Pedersen, Natalia</creatorcontrib><creatorcontrib>Andersen, Nynne Nyboe</creatorcontrib><creatorcontrib>Végh, Zsuzsanna</creatorcontrib><creatorcontrib>Jensen, Lisbeth</creatorcontrib><creatorcontrib>Ankersen, Dorit Vedel</creatorcontrib><creatorcontrib>Felding, Maria</creatorcontrib><creatorcontrib>Simonsen, Mette Hestetun</creatorcontrib><creatorcontrib>Burisch, Johan</creatorcontrib><creatorcontrib>Munkholm, Pia</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pedersen, Natalia</au><au>Andersen, Nynne Nyboe</au><au>Végh, Zsuzsanna</au><au>Jensen, Lisbeth</au><au>Ankersen, Dorit Vedel</au><au>Felding, Maria</au><au>Simonsen, Mette Hestetun</au><au>Burisch, Johan</au><au>Munkholm, Pia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2014-11-21</date><risdate>2014</risdate><volume>20</volume><issue>43</issue><spage>16215</spage><epage>16226</epage><pages>16215-16226</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM:To investigate the effects of a low fermentable,oligosaccharides,disaccharides,monosaccharides and polyols diet(LFD)and the probiotic Lactobacillus rhamnosus GG(LGG)in irritable bowel syndrome(IBS).METHODS:Randomised,unblinded controlled trial on the effect of 6-wk treatment with LFD,LGG or a normal Danish/Western diet(ND)in patients with IBS fulfilling Rome III diagnostic criteria,recruited betweenNovember 2009 and April 2013.Patients were required to complete on a weekly basis the IBS severity score system(IBS-SSS)and IBS quality of life(IBS-QOL)questionnaires in a specially developed IBS web selfmonitoring application.We investigated whether LFD or LGG could reduce IBS-SSS and improve QOL in IBS patients.RESULTS:One hundred twenty-three(median age 37years,range:18-74 years),90(73%)females were randomised:42 to LFD,41 to LGG and 40 to ND.A significant reduction in mean±SD of IBS-SSS from baseline to week 6 between LFD vs LGG vs ND was revealed:133±122 vs 68±107,133±122 vs 34±95,P&lt;0.01.Adjusted changes of IBS-SSS for baseline covariates showed statistically significant reduction of IBS-SSS in LFD group compared to ND(IBS-SSS score75;95%CI:24-126,P&lt;0.01),but not in LGG compared to ND(IBS-SSS score 32;95%CI:18-80,P=0.20).IBS-QOL was not altered significantly in any of the three groups:mean±SD in LFD 8±18 vs LGG 7±17,LFD 8±18 vs ND 0.1±15,P=0.13.CONCLUSION:LFD is efficacious for patients with IBS.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>25473176</pmid><doi>10.3748/wjg.v20.i43.16215</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged bowel Denmark Diet, Carbohydrate-Restricted Dietary Carbohydrates - metabolism Feasibility Studies Female Fermentation Humans Internet Irritable Irritable Bowel Syndrome - diagnosis Irritable Bowel Syndrome - diet therapy Irritable Bowel Syndrome - metabolism Irritable Bowel Syndrome - microbiology Lactobacillus rhamnosus - physiology Low Male management Middle Aged Original Patient Dropouts Probiotics - therapeutic use Quality of Life Severity of Illness Index Surveys and Questionnaires syndrome Time Factors Treatment Outcome Web-based Young Adult |
| title | Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome |
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