Hyperpolarized butyrate: A metabolic probe of short chain fatty acid metabolism in the heart

Purpose Butyrate, a short chain fatty acid, was studied as a novel hyperpolarized substrate for use in dynamic nuclear polarization enhanced magnetic resonance spectroscopy experiments, to define the pathways of short chain fatty acid and ketone body metabolism in real time. Methods Butyrate was pol...

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Veröffentlicht in:	Magnetic resonance in medicine 2014-05, Vol.71 (5), p.1663-1669
Hauptverfasser:	Ball, Daniel R., Rowlands, Ben, Dodd, Michael S., Le Page, Lydia, Ball, Vicky, Carr, Carolyn A., Clarke, Kieran, Tyler, Damian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals butyrate Butyrates - pharmacokinetics Carbon Isotopes - pharmacokinetics dynamic nuclear polarization Fatty Acids, Volatile - metabolism heart hyperpolarization In Vitro Techniques Isotope Labeling ketone bodies magnetic resonance spectroscopy Male Molecular Probe Techniques Myocardium - metabolism Proton Magnetic Resonance Spectroscopy - methods Radiopharmaceuticals - pharmacokinetics Rats Rats, Wistar short chain fatty acids Spectroscopic Methodology—Notes Tissue Distribution
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