Incidence of remission in adults with type 2 diabetes: the diabetes & aging study
To estimate the incidence of remission in adults with type 2 diabetes not treated with bariatric surgery and to identify variables associated with remission. We quantified the incidence of diabetes remission and examined its correlates among 122,781 adults with type 2 diabetes in an integrated healt...
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| Veröffentlicht in: | Diabetes care 2014-12, Vol.37 (12), p.3188-3195 |
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| creator | Karter, Andrew J Nundy, Shantanu Parker, Melissa M Moffet, Howard H Huang, Elbert S |
| description | To estimate the incidence of remission in adults with type 2 diabetes not treated with bariatric surgery and to identify variables associated with remission.
We quantified the incidence of diabetes remission and examined its correlates among 122,781 adults with type 2 diabetes in an integrated healthcare delivery system. Remission required the absence of ongoing drug therapy and was defined as follows: 1) partial: at least 1 year of subdiabetic hyperglycemia (hemoglobin A1c [HbA₁c] level 5.7-6.4% [39-46 mmol/mol]); 2) complete: at least 1 year of normoglycemia (HbA₁c level |
| doi_str_mv | 10.2337/dc14-0874 |
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We quantified the incidence of diabetes remission and examined its correlates among 122,781 adults with type 2 diabetes in an integrated healthcare delivery system. Remission required the absence of ongoing drug therapy and was defined as follows: 1) partial: at least 1 year of subdiabetic hyperglycemia (hemoglobin A1c [HbA₁c] level 5.7-6.4% [39-46 mmol/mol]); 2) complete: at least 1 year of normoglycemia (HbA₁c level <5.7% [<39 mmol/mol]); and 3) prolonged: complete remission for at least 5 years.
The incidence density (remissions per 1,000 person-years; 95% CI) of partial, complete, or prolonged remission was 2.8 (2.6-2.9), 0.24 (0.20-0.28), and 0.04 (0.01-0.06), respectively. The 7-year cumulative incidence of partial, complete, or prolonged remission was 1.47% (1.40-1.54%), 0.14% (0.12-0.16%), and 0.007% (0.003-0.020%), respectively. The 7-year cumulative incidence of achieving any remission was 1.60% in the whole cohort (1.53-1.68%) and 4.6% in the subgroup with new-onset diabetes (<2 years since diagnosis) (4.3-4.9%). After adjusting for demographic and clinical characteristics, correlates of remission included age >65 years, African American race, <2 years since diagnosis, baseline HbA₁c level <5.7% (<39 mmol/mol), and no diabetes medication at baseline.
In community settings, remission of type 2 diabetes does occur without bariatric surgery, but it is very rare.]]></description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc14-0874</identifier><identifier>PMID: 25231895</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>United States: American Diabetes Association</publisher><subject>Adult ; Aged ; Aging ; Bariatric Surgery - statistics & numerical data ; Cohort Studies ; Correlation analysis ; Diabetes ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - therapy ; Drug therapy ; Epidemiology/Health Services Research ; Female ; Gastrointestinal surgery ; Health care delivery ; Humans ; Incidence ; Male ; Middle Aged ; Remission Induction</subject><ispartof>Diabetes care, 2014-12, Vol.37 (12), p.3188-3195</ispartof><rights>2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.</rights><rights>Copyright American Diabetes Association Dec 2014</rights><rights>2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-ae7f472b65d12e3e0a51195f8b22960c29e262b9d36bff03c0f6a54bc92a9eca3</citedby><cites>FETCH-LOGICAL-c436t-ae7f472b65d12e3e0a51195f8b22960c29e262b9d36bff03c0f6a54bc92a9eca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25231895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karter, Andrew J</creatorcontrib><creatorcontrib>Nundy, Shantanu</creatorcontrib><creatorcontrib>Parker, Melissa M</creatorcontrib><creatorcontrib>Moffet, Howard H</creatorcontrib><creatorcontrib>Huang, Elbert S</creatorcontrib><title>Incidence of remission in adults with type 2 diabetes: the diabetes & aging study</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description><![CDATA[To estimate the incidence of remission in adults with type 2 diabetes not treated with bariatric surgery and to identify variables associated with remission.
We quantified the incidence of diabetes remission and examined its correlates among 122,781 adults with type 2 diabetes in an integrated healthcare delivery system. Remission required the absence of ongoing drug therapy and was defined as follows: 1) partial: at least 1 year of subdiabetic hyperglycemia (hemoglobin A1c [HbA₁c] level 5.7-6.4% [39-46 mmol/mol]); 2) complete: at least 1 year of normoglycemia (HbA₁c level <5.7% [<39 mmol/mol]); and 3) prolonged: complete remission for at least 5 years.
The incidence density (remissions per 1,000 person-years; 95% CI) of partial, complete, or prolonged remission was 2.8 (2.6-2.9), 0.24 (0.20-0.28), and 0.04 (0.01-0.06), respectively. The 7-year cumulative incidence of partial, complete, or prolonged remission was 1.47% (1.40-1.54%), 0.14% (0.12-0.16%), and 0.007% (0.003-0.020%), respectively. The 7-year cumulative incidence of achieving any remission was 1.60% in the whole cohort (1.53-1.68%) and 4.6% in the subgroup with new-onset diabetes (<2 years since diagnosis) (4.3-4.9%). After adjusting for demographic and clinical characteristics, correlates of remission included age >65 years, African American race, <2 years since diagnosis, baseline HbA₁c level <5.7% (<39 mmol/mol), and no diabetes medication at baseline.
In community settings, remission of type 2 diabetes does occur without bariatric surgery, but it is very rare.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Bariatric Surgery - statistics & numerical data</subject><subject>Cohort Studies</subject><subject>Correlation analysis</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>Drug therapy</subject><subject>Epidemiology/Health Services Research</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Health care delivery</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Remission Induction</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1r3DAQhkVpaDZpD_0DQVAoycGpNJIsK4dCWPIFgVJoz0KWx7sKXnljyQn77-Ml6dLklJMY9PAy7zyEfOXsFITQPxrPZcEqLT-QGTdCFUrJ6iOZMS5NoYyBfXKQ0h1jTMqq-kT2QYHglVEz8vsm-tBg9Ej7lg64CimFPtIQqWvGLif6GPKS5s0aKdAmuBozpjOal7ib6HfqFiEuaMpjs_lM9lrXJfzy8h6Sv5cXf-bXxe2vq5v5-W3hpShz4VC3UkNdqoYDCmROcW5UW9UApmQeDEIJtWlEWbctE561pVOy9gacQe_EIfn5nLse6xU2HmMeXGfXQ1i5YWN7F-zrnxiWdtE_WAlCGy2ngOOXgKG_HzFlO5X32HUuYj8my0sFuqwEVO9AQTM9FRAT-u0NetePQ5wuMVGSaSkVYxN18kz5oU9pwHa3N2d269Rundqt04k9-r_ojvwnUTwBoJSbaA</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Karter, Andrew J</creator><creator>Nundy, Shantanu</creator><creator>Parker, Melissa M</creator><creator>Moffet, Howard H</creator><creator>Huang, Elbert S</creator><general>American Diabetes Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>5PM</scope></search><sort><creationdate>20141201</creationdate><title>Incidence of remission in adults with type 2 diabetes: the diabetes & aging study</title><author>Karter, Andrew J ; Nundy, Shantanu ; Parker, Melissa M ; Moffet, Howard H ; Huang, Elbert S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-ae7f472b65d12e3e0a51195f8b22960c29e262b9d36bff03c0f6a54bc92a9eca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Bariatric Surgery - statistics & numerical data</topic><topic>Cohort Studies</topic><topic>Correlation analysis</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>Drug therapy</topic><topic>Epidemiology/Health Services Research</topic><topic>Female</topic><topic>Gastrointestinal surgery</topic><topic>Health care delivery</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Remission Induction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karter, Andrew J</creatorcontrib><creatorcontrib>Nundy, Shantanu</creatorcontrib><creatorcontrib>Parker, Melissa M</creatorcontrib><creatorcontrib>Moffet, Howard H</creatorcontrib><creatorcontrib>Huang, Elbert S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karter, Andrew J</au><au>Nundy, Shantanu</au><au>Parker, Melissa M</au><au>Moffet, Howard H</au><au>Huang, Elbert S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of remission in adults with type 2 diabetes: the diabetes & aging study</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>37</volume><issue>12</issue><spage>3188</spage><epage>3195</epage><pages>3188-3195</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract><![CDATA[To estimate the incidence of remission in adults with type 2 diabetes not treated with bariatric surgery and to identify variables associated with remission.
We quantified the incidence of diabetes remission and examined its correlates among 122,781 adults with type 2 diabetes in an integrated healthcare delivery system. Remission required the absence of ongoing drug therapy and was defined as follows: 1) partial: at least 1 year of subdiabetic hyperglycemia (hemoglobin A1c [HbA₁c] level 5.7-6.4% [39-46 mmol/mol]); 2) complete: at least 1 year of normoglycemia (HbA₁c level <5.7% [<39 mmol/mol]); and 3) prolonged: complete remission for at least 5 years.
The incidence density (remissions per 1,000 person-years; 95% CI) of partial, complete, or prolonged remission was 2.8 (2.6-2.9), 0.24 (0.20-0.28), and 0.04 (0.01-0.06), respectively. The 7-year cumulative incidence of partial, complete, or prolonged remission was 1.47% (1.40-1.54%), 0.14% (0.12-0.16%), and 0.007% (0.003-0.020%), respectively. The 7-year cumulative incidence of achieving any remission was 1.60% in the whole cohort (1.53-1.68%) and 4.6% in the subgroup with new-onset diabetes (<2 years since diagnosis) (4.3-4.9%). After adjusting for demographic and clinical characteristics, correlates of remission included age >65 years, African American race, <2 years since diagnosis, baseline HbA₁c level <5.7% (<39 mmol/mol), and no diabetes medication at baseline.
In community settings, remission of type 2 diabetes does occur without bariatric surgery, but it is very rare.]]></abstract><cop>United States</cop><pub>American Diabetes Association</pub><pmid>25231895</pmid><doi>10.2337/dc14-0874</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aging Bariatric Surgery - statistics & numerical data Cohort Studies Correlation analysis Diabetes Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - therapy Drug therapy Epidemiology/Health Services Research Female Gastrointestinal surgery Health care delivery Humans Incidence Male Middle Aged Remission Induction |
| title | Incidence of remission in adults with type 2 diabetes: the diabetes & aging study |
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