GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy

Seizures frequently accompany gliomas and often escalate to peritumoral epilepsy. Previous work revealed the importance of tumor‐derived excitatory glutamate (Glu) release mediated by the cystine‐glutamate transporter (SXC) in epileptogenesis. We now show a novel contribution of GABAergic disinhibit...

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Veröffentlicht in:	Glia 2015-01, Vol.63 (1), p.23-36
Hauptverfasser:	Campbell, Susan L., Robel, Stefanie, Cuddapah, Vishnu A., Robert, Stephanie, Buckingham, Susan C., Kahle, Kristopher T., Sontheimer, Harald
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Brain Neoplasms - complications Brain Neoplasms - metabolism Epilepsy Epilepsy - etiology Epilepsy - metabolism Female GABA gamma-Aminobutyric Acid - metabolism glioma Glioma - complications Glioma - metabolism Interneurons - metabolism K Cl- Cotransporters KCC2 Male Mice Neurons - metabolism peritumoral epilepsy Receptors, GABA-A - metabolism Symporters - metabolism Synaptic Transmission - physiology
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