Comparison of biological properties of umbilical cord-derived mesenchymal stem cells from early and late passages: Immunomodulatory ability is enhanced in aged cells

Mesenchymal stem cells (MSCs) are a potential source of adult stem cells for cell-based therapeutics due to their substantial multilineage differentiation capacity and secretory functions. No information is presently available regarding the maintenance of immunosuppressive properties of this cell ty...

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Veröffentlicht in:	Molecular medicine reports 2015-01, Vol.11 (1), p.166-174
Hauptverfasser:	ZHUANG, YONG, LI, DONG, FU, JINQIU, SHI, QING, LU, YUANYUAN, JU, XIULI
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antigens, Surface - metabolism beta-Galactosidase - metabolism Biosynthesis Cell Differentiation Cell Proliferation Cell surface Cellular Senescence - physiology Comparative analysis Computational Biology - methods Cytokines - genetics Cytokines - metabolism Cytology Dehydrogenases Flow cytometry Gene expression Gene Expression Profiling Gene Expression Regulation Genes Genetic aspects Graft-versus-host reaction Humans Immune system Immunomodulation Immunomodulators immunomodulatory ability Immunophenotyping Immunoregulation Immunosuppression Interleukin 6 Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - ultrastructure Mesenchyme Metabolism Molecular Sequence Annotation Morphology Ontology Physical characteristics Physiological aspects Senescence Stem cells Umbilical cord Umbilical Cord - cytology umbilical cord-mesenchymal stem cell
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