Induction of autophagy contributes to cisplatin resistance in human ovarian cancer cells

Cisplatin resistance is a major challenge in the clinical treatment of ovarian cancer, of which the underlying mechanisms remain unknown. The aim of the present study was to explore the role of autophagy in cisplatin resistance in ovarian cancer cells. A2780cp cisplatin-resistant ovarian carcinoma c...

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Veröffentlicht in:	Molecular medicine reports 2015-01, Vol.11 (1), p.91-98
Hauptverfasser:	BAO, LINGJIE, JARAMILLO, MELBA C, ZHANG, ZHENBO, ZHENG, YUNXI, YAO, MING, ZHANG, DONNA D, YI, XIAOFANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Autophagy Autophagy (Cytology) Autophagy - drug effects Autophagy - genetics Cancer therapies Cell death Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Chemotherapy Cisplatin Cisplatin - pharmacology Drug resistance Drug Resistance, Neoplasm - genetics Drug therapy Electron microscopy Esophageal cancer Female Flow cytometry Genetic aspects Health aspects Humans Kinases Laboratories Liver cancer Microtubule-associated protein 1 Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Phagocytosis Phagosomes Proteins resistance Risk factors RNA, Small Interfering siRNA Tetrazolium salt Transmission electron microscopy
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