Inhibition of lactate removal by ketone bodies in rat liver: evidence for a quantitatively important role of the plasma membrane lactate transporter in lactate metabolism

We studied the effect of DL-3-hydroxybutyrate and acetoacetate on lactate transport into isolated hepatocytes and on lactate removal in the isolated perfused rat liver. Ketone bodies inhibited lactate transport into isolated hepatocytes (maximum, 35% at concentrations of 10-20 mM). Lactate removal a...

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Veröffentlicht in:	The Journal of clinical investigation 1986-09, Vol.78 (3), p.743-747
Hauptverfasser:	METCALFE, H. K, MONSON, J. P, WELCH, S. G, COHEN, R. D
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxybutyric Acid Acetoacetates - pharmacology Animals Biological and medical sciences Biological Transport - drug effects Cell Membrane - metabolism Glucose - biosynthesis Hydroxybutyrates - metabolism Hydroxybutyrates - pharmacology Lactates - metabolism Lactic Acid Liver - drug effects Liver - metabolism Male Medical sciences Metabolic diseases Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Rats Rats, Inbred Strains
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