Non-parametric analysis of seasonality in birth and multiple sclerosis risk in second generation of migrants in Kuwait
There are inconsistent reports about multiple sclerosis (MS) risk among migrants from low to high MS risk geographical regions. This study assessed the overall MS incidence and evaluated seasonality in birth and subsequent MS risk later in the life in second generation of migrants born and lived in...
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| Veröffentlicht in: | BMC neurology 2014-08, Vol.14 (1), p.170-170, Article 170 |
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| creator | Akhtar, Saeed Alroughani, Raed Al-Shammari, Ahmad Al-Abkal, Jarrah Ayad, Yasser |
| description | There are inconsistent reports about multiple sclerosis (MS) risk among migrants from low to high MS risk geographical regions. This study assessed the overall MS incidence and evaluated seasonality in birth and subsequent MS risk later in the life in second generation of migrants born and lived in Kuwait.
We assessed the overall and gender-specific MS risk in second generation of migrants born and lived in Kuwait between January 1, 1950 and April 30, 2013. Data on migrants' MS patients diagnosed and registered in Kuwait National MS Registry were used. Hewitt's non-parametric test was carried out to evaluate the seasonality in migrants' MS births in comparison with the second generation migrants' births in general population.
During the study period, an overall risk of migrants' MS births (per 100,000 non-Kuwaiti births in general population) was 23.8 (95% CI: 20.8 - 27.0). Gender-specific MS risk showed that non-Kuwaiti female had statistically significant (p = 0.003) higher risk (28.6; 95% CI: 24.2 - 33.7) than non-Kuwaiti males (18.7; 95% CI: 15.1-23.0). The month-specific distribution of migrants' MS births compared with migrants' births in general population did not differ significantly (χ2 goodness-of-fit test statistic = 9.51, p = 0.575). Hewitt's non-parametric test revealed an evidence of slight but statistically non-significant (p = 0.090) increased tendency of migrants' MS births during September through February.
The proportion of migrants' MS births (per 100,000 migrants' births in general population) over the study period was 23.8 (95% CI: 20.8 - 27.0), which was statistically significantly higher than the previously reported Kuwaiti national MS births (16.2; 95% CI: 15.1-17.4) in Kuwait. Non-parametric analysis showed slight but statistically non-significant increased tendency of migrants' MS births from September through February. Knowledge of MS risk factors and how and when they act among genetically vulnerable individuals from gestation to early adulthood will help design prevention strategies. |
| doi_str_mv | 10.1186/s12883-014-0170-7 |
| format | Article |
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We assessed the overall and gender-specific MS risk in second generation of migrants born and lived in Kuwait between January 1, 1950 and April 30, 2013. Data on migrants' MS patients diagnosed and registered in Kuwait National MS Registry were used. Hewitt's non-parametric test was carried out to evaluate the seasonality in migrants' MS births in comparison with the second generation migrants' births in general population.
During the study period, an overall risk of migrants' MS births (per 100,000 non-Kuwaiti births in general population) was 23.8 (95% CI: 20.8 - 27.0). Gender-specific MS risk showed that non-Kuwaiti female had statistically significant (p = 0.003) higher risk (28.6; 95% CI: 24.2 - 33.7) than non-Kuwaiti males (18.7; 95% CI: 15.1-23.0). The month-specific distribution of migrants' MS births compared with migrants' births in general population did not differ significantly (χ2 goodness-of-fit test statistic = 9.51, p = 0.575). Hewitt's non-parametric test revealed an evidence of slight but statistically non-significant (p = 0.090) increased tendency of migrants' MS births during September through February.
The proportion of migrants' MS births (per 100,000 migrants' births in general population) over the study period was 23.8 (95% CI: 20.8 - 27.0), which was statistically significantly higher than the previously reported Kuwaiti national MS births (16.2; 95% CI: 15.1-17.4) in Kuwait. Non-parametric analysis showed slight but statistically non-significant increased tendency of migrants' MS births from September through February. Knowledge of MS risk factors and how and when they act among genetically vulnerable individuals from gestation to early adulthood will help design prevention strategies.</description><identifier>ISSN: 1471-2377</identifier><identifier>EISSN: 1471-2377</identifier><identifier>DOI: 10.1186/s12883-014-0170-7</identifier><identifier>PMID: 25154872</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Births ; Care and treatment ; Complications and side effects ; Development and progression ; Female ; Health aspects ; Hospitals ; Humans ; Kuwait - epidemiology ; Male ; Mortality ; Multiple sclerosis ; Multiple Sclerosis - epidemiology ; Neurology ; Patient outcomes ; Population ; Registries ; Risk Factors ; Seasons ; Statistics, Nonparametric ; Studies ; Transients and Migrants ; Vitamin deficiency</subject><ispartof>BMC neurology, 2014-08, Vol.14 (1), p.170-170, Article 170</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Akhtar et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Copyright © 2014 Akhtar et al.; licensee BioMed Central Ltd. 2014 Akhtar et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-f4e99edf09b593219b3295532c193d35a61cfbbbe30342079bc857971aa57b673</citedby><cites>FETCH-LOGICAL-c527t-f4e99edf09b593219b3295532c193d35a61cfbbbe30342079bc857971aa57b673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236647/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236647/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25154872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akhtar, Saeed</creatorcontrib><creatorcontrib>Alroughani, Raed</creatorcontrib><creatorcontrib>Al-Shammari, Ahmad</creatorcontrib><creatorcontrib>Al-Abkal, Jarrah</creatorcontrib><creatorcontrib>Ayad, Yasser</creatorcontrib><title>Non-parametric analysis of seasonality in birth and multiple sclerosis risk in second generation of migrants in Kuwait</title><title>BMC neurology</title><addtitle>BMC Neurol</addtitle><description>There are inconsistent reports about multiple sclerosis (MS) risk among migrants from low to high MS risk geographical regions. This study assessed the overall MS incidence and evaluated seasonality in birth and subsequent MS risk later in the life in second generation of migrants born and lived in Kuwait.
We assessed the overall and gender-specific MS risk in second generation of migrants born and lived in Kuwait between January 1, 1950 and April 30, 2013. Data on migrants' MS patients diagnosed and registered in Kuwait National MS Registry were used. Hewitt's non-parametric test was carried out to evaluate the seasonality in migrants' MS births in comparison with the second generation migrants' births in general population.
During the study period, an overall risk of migrants' MS births (per 100,000 non-Kuwaiti births in general population) was 23.8 (95% CI: 20.8 - 27.0). Gender-specific MS risk showed that non-Kuwaiti female had statistically significant (p = 0.003) higher risk (28.6; 95% CI: 24.2 - 33.7) than non-Kuwaiti males (18.7; 95% CI: 15.1-23.0). The month-specific distribution of migrants' MS births compared with migrants' births in general population did not differ significantly (χ2 goodness-of-fit test statistic = 9.51, p = 0.575). Hewitt's non-parametric test revealed an evidence of slight but statistically non-significant (p = 0.090) increased tendency of migrants' MS births during September through February.
The proportion of migrants' MS births (per 100,000 migrants' births in general population) over the study period was 23.8 (95% CI: 20.8 - 27.0), which was statistically significantly higher than the previously reported Kuwaiti national MS births (16.2; 95% CI: 15.1-17.4) in Kuwait. Non-parametric analysis showed slight but statistically non-significant increased tendency of migrants' MS births from September through February. Knowledge of MS risk factors and how and when they act among genetically vulnerable individuals from gestation to early adulthood will help design prevention strategies.</description><subject>Births</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Female</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Kuwait - epidemiology</subject><subject>Male</subject><subject>Mortality</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - epidemiology</subject><subject>Neurology</subject><subject>Patient outcomes</subject><subject>Population</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Seasons</subject><subject>Statistics, Nonparametric</subject><subject>Studies</subject><subject>Transients and Migrants</subject><subject>Vitamin deficiency</subject><issn>1471-2377</issn><issn>1471-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkktrFTEYhgdRbK3-ADcy4MbN1Fwmt41Qijda2o2uQybzzWnqTHJMMpXz7004tbbFhYSQ2_O9JG_epnmN0THGkr9PmEhJO4T70gXqxJPmEPcCd4QK8fTe_KB5kdI1KpDs8fPmgDDMeinIYXNzEXy3NdEskKOzrfFm3iWX2jC1CUwKZe3yrnW-HVzMVwUY22Wds9vO0CY7QwwVjy79qFACGwqxAQ_RZBd8FVrcJhqfUwXO1l_G5ZfNs8nMCV7djkfN908fv51-6c4vP389PTnvLCMid1MPSsE4ITUwRQlWAyWKMUosVnSkzHBsp2EYgCLaEyTUYCUTSmBjmBi4oEfNh73udh0WGC34HM2st9EtJu50ME4_PPHuSm_Cje4J5byvAu9uBWL4uULKenHJwjwbD2FNGjPOJUWK8f9AmWSEEyIL-vYReh3WWKzeCyJFynv-Uhszg3Z-CuWKtorqE0YVk1zhSh3_gypthMWVz4DJlf0HBXhfYMvXpQjTnR0Y6Zorvc-VLrnSNVe62vDmvo93FX-CRH8D5QrIhg</recordid><startdate>20140826</startdate><enddate>20140826</enddate><creator>Akhtar, Saeed</creator><creator>Alroughani, Raed</creator><creator>Al-Shammari, Ahmad</creator><creator>Al-Abkal, Jarrah</creator><creator>Ayad, Yasser</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140826</creationdate><title>Non-parametric analysis of seasonality in birth and multiple sclerosis risk in second generation of migrants in Kuwait</title><author>Akhtar, Saeed ; Alroughani, Raed ; Al-Shammari, Ahmad ; Al-Abkal, Jarrah ; Ayad, Yasser</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-f4e99edf09b593219b3295532c193d35a61cfbbbe30342079bc857971aa57b673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Births</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Female</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Kuwait - epidemiology</topic><topic>Male</topic><topic>Mortality</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - epidemiology</topic><topic>Neurology</topic><topic>Patient outcomes</topic><topic>Population</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Seasons</topic><topic>Statistics, Nonparametric</topic><topic>Studies</topic><topic>Transients and Migrants</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akhtar, Saeed</creatorcontrib><creatorcontrib>Alroughani, Raed</creatorcontrib><creatorcontrib>Al-Shammari, Ahmad</creatorcontrib><creatorcontrib>Al-Abkal, Jarrah</creatorcontrib><creatorcontrib>Ayad, Yasser</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akhtar, Saeed</au><au>Alroughani, Raed</au><au>Al-Shammari, Ahmad</au><au>Al-Abkal, Jarrah</au><au>Ayad, Yasser</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-parametric analysis of seasonality in birth and multiple sclerosis risk in second generation of migrants in Kuwait</atitle><jtitle>BMC neurology</jtitle><addtitle>BMC Neurol</addtitle><date>2014-08-26</date><risdate>2014</risdate><volume>14</volume><issue>1</issue><spage>170</spage><epage>170</epage><pages>170-170</pages><artnum>170</artnum><issn>1471-2377</issn><eissn>1471-2377</eissn><abstract>There are inconsistent reports about multiple sclerosis (MS) risk among migrants from low to high MS risk geographical regions. This study assessed the overall MS incidence and evaluated seasonality in birth and subsequent MS risk later in the life in second generation of migrants born and lived in Kuwait.
We assessed the overall and gender-specific MS risk in second generation of migrants born and lived in Kuwait between January 1, 1950 and April 30, 2013. Data on migrants' MS patients diagnosed and registered in Kuwait National MS Registry were used. Hewitt's non-parametric test was carried out to evaluate the seasonality in migrants' MS births in comparison with the second generation migrants' births in general population.
During the study period, an overall risk of migrants' MS births (per 100,000 non-Kuwaiti births in general population) was 23.8 (95% CI: 20.8 - 27.0). Gender-specific MS risk showed that non-Kuwaiti female had statistically significant (p = 0.003) higher risk (28.6; 95% CI: 24.2 - 33.7) than non-Kuwaiti males (18.7; 95% CI: 15.1-23.0). The month-specific distribution of migrants' MS births compared with migrants' births in general population did not differ significantly (χ2 goodness-of-fit test statistic = 9.51, p = 0.575). Hewitt's non-parametric test revealed an evidence of slight but statistically non-significant (p = 0.090) increased tendency of migrants' MS births during September through February.
The proportion of migrants' MS births (per 100,000 migrants' births in general population) over the study period was 23.8 (95% CI: 20.8 - 27.0), which was statistically significantly higher than the previously reported Kuwaiti national MS births (16.2; 95% CI: 15.1-17.4) in Kuwait. Non-parametric analysis showed slight but statistically non-significant increased tendency of migrants' MS births from September through February. Knowledge of MS risk factors and how and when they act among genetically vulnerable individuals from gestation to early adulthood will help design prevention strategies.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25154872</pmid><doi>10.1186/s12883-014-0170-7</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Births Care and treatment Complications and side effects Development and progression Female Health aspects Hospitals Humans Kuwait - epidemiology Male Mortality Multiple sclerosis Multiple Sclerosis - epidemiology Neurology Patient outcomes Population Registries Risk Factors Seasons Statistics, Nonparametric Studies Transients and Migrants Vitamin deficiency |
| title | Non-parametric analysis of seasonality in birth and multiple sclerosis risk in second generation of migrants in Kuwait |
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