The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome

The majority of Lynch syndrome (LS), also known as hereditary non-polyposis colorectal cancer (HNPCC), has been linked to heterozygous defects in DNA mismatch repair (MMR). MMR is a highly conserved pathway that recognizes and repairs polymerase misincorporation errors and nucleotide damage as well...

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Veröffentlicht in:	Familial cancer 2013-06, Vol.12 (2), p.159-168
Hauptverfasser:	Martín-López, Juana V., Fishel, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cancer Research Colorectal Neoplasms, Hereditary Nonpolyposis - genetics DNA Mismatch Repair - genetics Epidemiology Human Genetics Humans Original Article
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