Positive inotropic and vasodilator actions of milrinone in patients with severe congestive heart failure: dose-response relationships and comparison to nitroprusside

Milrinone is a potent positive inotropic and vascular smooth muscle-relaxing agent in vitro, and therefore, it is not known to what extent each of these actions contributes to the drug's hemodynamic effects in patients with heart failure. In 11 patients with New York Heart Association class III...

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Veröffentlicht in:	The Journal of clinical investigation 1985-02, Vol.75 (2), p.643-649
Hauptverfasser:	JASKI, B. E, FIFER, M. A, WRIGHT, R. F, BRAUNWALD, E, COLUCCI, W. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Cardiotonic agents Cardiotonic Agents - administration & dosage Cardiovascular system Dose-Response Relationship, Drug Female Heart Failure - drug therapy Heart Failure - physiopathology Hemodynamics - drug effects Humans Male Medical sciences Middle Aged Milrinone Nitroprusside - administration & dosage Pharmacology. Drug treatments Pyridones - administration & dosage Vasodilator Agents - administration & dosage
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