Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes

Eukaryotic RNAs with premature termination codons (PTCs) are eliminated by nonsense-mediated decay (NMD). While human nonsense RNA degradation can be initiated either by an endonucleolytic cleavage event near the PTC or through decapping, the individual contribution of these activities on endogenous...

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Veröffentlicht in:	Genes & development 2014-11, Vol.28 (22), p.2498-2517
Hauptverfasser:	Lykke-Andersen, Søren, Chen, Yun, Ardal, Britt R, Lilje, Berit, Waage, Johannes, Sandelin, Albin, Jensen, Torben Heick
Format:	Artikel
Sprache:	eng
Schlagworte:	Endonucleases - metabolism HEK293 Cells Humans Nonsense Mediated mRNA Decay - genetics Nonsense Mediated mRNA Decay - physiology Protein Isoforms Research Paper RNA Splicing RNA, Small Nucleolar - metabolism Telomerase - genetics Telomerase - metabolism
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