Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis
Our aim was to evaluate the safety and efficacy of a low-intensity resistance training program combined with partial blow flow restriction (BFR training) in a cohort of patients with polymyositis (PM) and dermatomyositis (DM). In total, 13 patients with PM and DM completed a 12-week twice a week low...
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| Veröffentlicht in: | Arthritis research & therapy 2014-10, Vol.16 (5), p.473-473, Article 473 |
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| creator | Mattar, Melina Andrade Gualano, Bruno Perandini, Luiz Augusto Shinjo, Samuel Katsuyuki Lima, Fernanda Rodrigues Sá-Pinto, Ana Lúcia Roschel, Hamilton |
| description | Our aim was to evaluate the safety and efficacy of a low-intensity resistance training program combined with partial blow flow restriction (BFR training) in a cohort of patients with polymyositis (PM) and dermatomyositis (DM).
In total, 13 patients with PM and DM completed a 12-week twice a week low-intensity (that is, 30% one-repetition-maximum (1RM)) resistance exercise training program combined with partial blood flow restriction (BFR). Assessments of muscle strength, physical function, quadriceps cross sectional (CSA) area, health-related quality of life, and clinical and laboratory parameters were assessed at baseline and after the intervention.
The BFR training program was effective in increasing the maximal dynamic strength in both the leg-press (19.6%, P |
| doi_str_mv | 10.1186/s13075-014-0473-5 |
| format | Article |
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In total, 13 patients with PM and DM completed a 12-week twice a week low-intensity (that is, 30% one-repetition-maximum (1RM)) resistance exercise training program combined with partial blood flow restriction (BFR). Assessments of muscle strength, physical function, quadriceps cross sectional (CSA) area, health-related quality of life, and clinical and laboratory parameters were assessed at baseline and after the intervention.
The BFR training program was effective in increasing the maximal dynamic strength in both the leg-press (19.6%, P <0.001) and knee-extension exercises (25.2% P <0.001), as well as in the timed-stands (15.1%, P <0.001) and timed-up-and-go test (-4.5%, P =0.002). Quadriceps CSA was also significantly increased after the intervention (4.57%, P =0.01). Similarly, all of the components of the Short Form-36 Health Survey, the Health Assessment Questionnaire scores, and the patient- and physician reported Visual Analogue Scale were significantly improved after training (P <0.05). Importantly, no clinical evidence or any other self-reported adverse event were found. Laboratory parameters (creatine kinase and aldolase) were also unchanged (P >0.05) after the intervention.
We demonstrated that a 12-week supervised low-intensity resistance training program associated with partial blood flow restriction may be safe and effective in improving muscle strength and function as well as muscle mass and health-related quality of life in patients with PM and DM.
Clinicaltrials.gov NCT01501019. Registered November 29, 2011.</description><identifier>ISSN: 1478-6354</identifier><identifier>EISSN: 1478-6362</identifier><identifier>EISSN: 1478-6354</identifier><identifier>DOI: 10.1186/s13075-014-0473-5</identifier><identifier>PMID: 25344395</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Analysis ; Blood Flow Velocity ; Care and treatment ; Creatine ; Creatine kinase ; Dermatomyositis - physiopathology ; Dermatomyositis - therapy ; Female ; Health aspects ; Humans ; Longitudinal Studies ; Male ; Medical colleges ; Middle Aged ; Muscle Strength ; Muscle, Skeletal - blood supply ; Muscle, Skeletal - physiopathology ; Polymyositis ; Polymyositis - physiopathology ; Polymyositis - therapy ; Prospective Studies ; Quadriceps Muscle - blood supply ; Quadriceps Muscle - physiopathology ; Quality of Life ; Resistance Training - methods ; Surveys and Questionnaires ; Treatment Outcome ; Visual Analog Scale</subject><ispartof>Arthritis research & therapy, 2014-10, Vol.16 (5), p.473-473, Article 473</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>Mattar et al.; licensee BioMed Central Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b597t-47840ef8fa1e044312589450e3253ef730dbddaaf40a31b523cd45c89d80e5fb3</citedby><cites>FETCH-LOGICAL-b597t-47840ef8fa1e044312589450e3253ef730dbddaaf40a31b523cd45c89d80e5fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232679/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232679/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25344395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mattar, Melina Andrade</creatorcontrib><creatorcontrib>Gualano, Bruno</creatorcontrib><creatorcontrib>Perandini, Luiz Augusto</creatorcontrib><creatorcontrib>Shinjo, Samuel Katsuyuki</creatorcontrib><creatorcontrib>Lima, Fernanda Rodrigues</creatorcontrib><creatorcontrib>Sá-Pinto, Ana Lúcia</creatorcontrib><creatorcontrib>Roschel, Hamilton</creatorcontrib><title>Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis</title><title>Arthritis research & therapy</title><addtitle>Arthritis Res Ther</addtitle><description>Our aim was to evaluate the safety and efficacy of a low-intensity resistance training program combined with partial blow flow restriction (BFR training) in a cohort of patients with polymyositis (PM) and dermatomyositis (DM).
In total, 13 patients with PM and DM completed a 12-week twice a week low-intensity (that is, 30% one-repetition-maximum (1RM)) resistance exercise training program combined with partial blood flow restriction (BFR). Assessments of muscle strength, physical function, quadriceps cross sectional (CSA) area, health-related quality of life, and clinical and laboratory parameters were assessed at baseline and after the intervention.
The BFR training program was effective in increasing the maximal dynamic strength in both the leg-press (19.6%, P <0.001) and knee-extension exercises (25.2% P <0.001), as well as in the timed-stands (15.1%, P <0.001) and timed-up-and-go test (-4.5%, P =0.002). Quadriceps CSA was also significantly increased after the intervention (4.57%, P =0.01). Similarly, all of the components of the Short Form-36 Health Survey, the Health Assessment Questionnaire scores, and the patient- and physician reported Visual Analogue Scale were significantly improved after training (P <0.05). Importantly, no clinical evidence or any other self-reported adverse event were found. Laboratory parameters (creatine kinase and aldolase) were also unchanged (P >0.05) after the intervention.
We demonstrated that a 12-week supervised low-intensity resistance training program associated with partial blood flow restriction may be safe and effective in improving muscle strength and function as well as muscle mass and health-related quality of life in patients with PM and DM.
Clinicaltrials.gov NCT01501019. Registered November 29, 2011.</description><subject>Adult</subject><subject>Analysis</subject><subject>Blood Flow Velocity</subject><subject>Care and treatment</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Dermatomyositis - physiopathology</subject><subject>Dermatomyositis - therapy</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical colleges</subject><subject>Middle Aged</subject><subject>Muscle Strength</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Polymyositis</subject><subject>Polymyositis - physiopathology</subject><subject>Polymyositis - therapy</subject><subject>Prospective Studies</subject><subject>Quadriceps Muscle - blood supply</subject><subject>Quadriceps Muscle - physiopathology</subject><subject>Quality of Life</subject><subject>Resistance Training - methods</subject><subject>Surveys and Questionnaires</subject><subject>Treatment Outcome</subject><subject>Visual Analog Scale</subject><issn>1478-6354</issn><issn>1478-6362</issn><issn>1478-6354</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UstuFDEQHCEQCYEP4IIsceEywR7b87ggReEpReIAnC2P3d40mrEX25tov4MfxsMkK1YK8sFWd1V1l7ur6iWj54z17dvEOO1kTZmoqeh4LR9Vp0x0fd3ytnl8eEtxUj1L6SelTTM04ml10kguBB_kafX7m3aQ90R7S7YhJRwnIOAcmJxIcGQKtzX6DD5hQUVImLL2BkiOGj36DdEpBYM6gyW3mK_JVseMeiLjFIIlrggstBzRZAyeoC91pv28D0UR09_CFuKsc7iPPa-eOD0leHF3n1U_Pn74fvm5vvr66cvlxVU9yqHLdTEnKLjeaQa02GGN7AchKfBiD1zHqR2t1doJqjkbZcONFdL0g-0pSDfys-rdqrvdjTNYA76YmtQ24qzjXgWN6jjj8Vptwo0SDW_abigC71eBEcN_BI4zJsxqHZoqQ1PL0JQsMm_u-ojh1678lZoxGZgm7SHskmKtKM0LJhfo6xW60RMo9C4UXbPA1YUUtOe8Y11BnT-AKsfCjCZ4cFjiRwS2EkwsOxDBHTwwqpZVe7DrV__-3oFxv1v8DxGG1CU</recordid><startdate>20141025</startdate><enddate>20141025</enddate><creator>Mattar, Melina Andrade</creator><creator>Gualano, Bruno</creator><creator>Perandini, Luiz Augusto</creator><creator>Shinjo, Samuel Katsuyuki</creator><creator>Lima, Fernanda Rodrigues</creator><creator>Sá-Pinto, Ana Lúcia</creator><creator>Roschel, Hamilton</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141025</creationdate><title>Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis</title><author>Mattar, Melina Andrade ; Gualano, Bruno ; Perandini, Luiz Augusto ; Shinjo, Samuel Katsuyuki ; Lima, Fernanda Rodrigues ; Sá-Pinto, Ana Lúcia ; Roschel, Hamilton</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b597t-47840ef8fa1e044312589450e3253ef730dbddaaf40a31b523cd45c89d80e5fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Blood Flow Velocity</topic><topic>Care and treatment</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Dermatomyositis - physiopathology</topic><topic>Dermatomyositis - therapy</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical colleges</topic><topic>Middle Aged</topic><topic>Muscle Strength</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Polymyositis</topic><topic>Polymyositis - physiopathology</topic><topic>Polymyositis - therapy</topic><topic>Prospective Studies</topic><topic>Quadriceps Muscle - blood supply</topic><topic>Quadriceps Muscle - physiopathology</topic><topic>Quality of Life</topic><topic>Resistance Training - methods</topic><topic>Surveys and Questionnaires</topic><topic>Treatment Outcome</topic><topic>Visual Analog Scale</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mattar, Melina Andrade</creatorcontrib><creatorcontrib>Gualano, Bruno</creatorcontrib><creatorcontrib>Perandini, Luiz Augusto</creatorcontrib><creatorcontrib>Shinjo, Samuel Katsuyuki</creatorcontrib><creatorcontrib>Lima, Fernanda Rodrigues</creatorcontrib><creatorcontrib>Sá-Pinto, Ana Lúcia</creatorcontrib><creatorcontrib>Roschel, Hamilton</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arthritis research & therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mattar, Melina Andrade</au><au>Gualano, Bruno</au><au>Perandini, Luiz Augusto</au><au>Shinjo, Samuel Katsuyuki</au><au>Lima, Fernanda Rodrigues</au><au>Sá-Pinto, Ana Lúcia</au><au>Roschel, Hamilton</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis</atitle><jtitle>Arthritis research & therapy</jtitle><addtitle>Arthritis Res Ther</addtitle><date>2014-10-25</date><risdate>2014</risdate><volume>16</volume><issue>5</issue><spage>473</spage><epage>473</epage><pages>473-473</pages><artnum>473</artnum><issn>1478-6354</issn><eissn>1478-6362</eissn><eissn>1478-6354</eissn><abstract>Our aim was to evaluate the safety and efficacy of a low-intensity resistance training program combined with partial blow flow restriction (BFR training) in a cohort of patients with polymyositis (PM) and dermatomyositis (DM).
In total, 13 patients with PM and DM completed a 12-week twice a week low-intensity (that is, 30% one-repetition-maximum (1RM)) resistance exercise training program combined with partial blood flow restriction (BFR). Assessments of muscle strength, physical function, quadriceps cross sectional (CSA) area, health-related quality of life, and clinical and laboratory parameters were assessed at baseline and after the intervention.
The BFR training program was effective in increasing the maximal dynamic strength in both the leg-press (19.6%, P <0.001) and knee-extension exercises (25.2% P <0.001), as well as in the timed-stands (15.1%, P <0.001) and timed-up-and-go test (-4.5%, P =0.002). Quadriceps CSA was also significantly increased after the intervention (4.57%, P =0.01). Similarly, all of the components of the Short Form-36 Health Survey, the Health Assessment Questionnaire scores, and the patient- and physician reported Visual Analogue Scale were significantly improved after training (P <0.05). Importantly, no clinical evidence or any other self-reported adverse event were found. Laboratory parameters (creatine kinase and aldolase) were also unchanged (P >0.05) after the intervention.
We demonstrated that a 12-week supervised low-intensity resistance training program associated with partial blood flow restriction may be safe and effective in improving muscle strength and function as well as muscle mass and health-related quality of life in patients with PM and DM.
Clinicaltrials.gov NCT01501019. Registered November 29, 2011.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25344395</pmid><doi>10.1186/s13075-014-0473-5</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature - Complete Springer Journals; PubMed Central; Springer Nature OA/Free Journals |
| subjects | Adult Analysis Blood Flow Velocity Care and treatment Creatine Creatine kinase Dermatomyositis - physiopathology Dermatomyositis - therapy Female Health aspects Humans Longitudinal Studies Male Medical colleges Middle Aged Muscle Strength Muscle, Skeletal - blood supply Muscle, Skeletal - physiopathology Polymyositis Polymyositis - physiopathology Polymyositis - therapy Prospective Studies Quadriceps Muscle - blood supply Quadriceps Muscle - physiopathology Quality of Life Resistance Training - methods Surveys and Questionnaires Treatment Outcome Visual Analog Scale |
| title | Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis |
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