Interval lung cancers not detected on screening chest X-rays: How are they different?
Abstract Background The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial provides us an opportunity to describe interval lung cancers not detected by screening chest X-ray (CXR) compared to screen-detected cancers. Methods Participants were screened for lung cancer with CXR at baseline...
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| creator | Kvale, Paul A Johnson, Christine Cole Tammemägi, Martin Marcus, Pamela M Zylak, Carl J Spizarny, David L Hocking, William Oken, Martin Commins, John Ragard, Lawrence Hu, Ping Berg, Christine Prorok, Philip |
| description | Abstract Background The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial provides us an opportunity to describe interval lung cancers not detected by screening chest X-ray (CXR) compared to screen-detected cancers. Methods Participants were screened for lung cancer with CXR at baseline and annually for two (never smokers) or three (ever smokers) more years. Screen-detected cancers were those with a positive CXR and diagnosed within 12 months. Putative interval cancers were those with a negative CXR screen but with a diagnosis of lung cancer within 12 months. Potential interval cancers were re-reviewed to determine whether lung cancer was missed and probably present during the initial interpretation or whether the lesion was a “true interval” cancer. Results 77,445 participants were randomized to the intervention arm with 70,633 screened. Of 5227 positive screens from any screening round, 299 resulted in screen-detected lung cancers; 151 had potential interval cancers with 127 CXR available for re-review. Cancer was probably present in 45/127 (35.4%) at time of screening; 82 (64.6%) were “true interval” cancers. Compared to screen-detected cancers, true interval cancers were more common among males, persons with |
| doi_str_mv | 10.1016/j.lungcan.2014.07.013 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4232302</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0169500214003134</els_id><sourcerecordid>1564353854</sourcerecordid><originalsourceid>FETCH-LOGICAL-c622t-619ef2c81c2f0b7fc9aab773146bae439a81072c7ca6266baed1e6309d1f593d3</originalsourceid><addsrcrecordid>eNqFks9vFCEUx4nR2LX6J2i4mHiZkQfz00ObplHbpIkHbeLthWXedFlnocLMmv3vZbJrW3spFxL48H0PPjD2FkQOAqqP63yY3I3RLpcCilzUuQD1jC2gqWXWKCWfs0Xi2qwUQh6xVzGuhYAaRPuSHckSpEpjwa4v3Uhhqwc-x_GUZyhE7vzIOxrJjNRx73g0gcjZmVhRHPnPLOhd_MQv_B-uA_FxRTve2b6nQG48fc1e9HqI9OYwH7PrL59_nF9kV9--Xp6fXWWmknLMKmipl6YBI3uxrHvTar2sawVFtdRUqFY3IGppaqMrWc1rHVClRNtBX7aqU8fsZJ97Oy031JlUO-gBb4Pd6LBDry3-v-PsCm_8FguppBIyBXw4BAT_e0o3w42NhoZBO_JTRCirQpWqKYuElnvUBB9joP6uDAicleAaD0pwVoKixqQknXv3sMe7U_8cJOD9AdDR6KEPyYGN91zTQLI2c6d7jtKLbi0FjMZS8tXZkERh5-2TrZw8SjCDdTYV_UU7ims_BZd0IWCUKPD7_H_m7wOFEApUof4CwYvCeA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1564353854</pqid></control><display><type>article</type><title>Interval lung cancers not detected on screening chest X-rays: How are they different?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kvale, Paul A ; Johnson, Christine Cole ; Tammemägi, Martin ; Marcus, Pamela M ; Zylak, Carl J ; Spizarny, David L ; Hocking, William ; Oken, Martin ; Commins, John ; Ragard, Lawrence ; Hu, Ping ; Berg, Christine ; Prorok, Philip</creator><creatorcontrib>Kvale, Paul A ; Johnson, Christine Cole ; Tammemägi, Martin ; Marcus, Pamela M ; Zylak, Carl J ; Spizarny, David L ; Hocking, William ; Oken, Martin ; Commins, John ; Ragard, Lawrence ; Hu, Ping ; Berg, Christine ; Prorok, Philip</creatorcontrib><description>Abstract Background The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial provides us an opportunity to describe interval lung cancers not detected by screening chest X-ray (CXR) compared to screen-detected cancers. Methods Participants were screened for lung cancer with CXR at baseline and annually for two (never smokers) or three (ever smokers) more years. Screen-detected cancers were those with a positive CXR and diagnosed within 12 months. Putative interval cancers were those with a negative CXR screen but with a diagnosis of lung cancer within 12 months. Potential interval cancers were re-reviewed to determine whether lung cancer was missed and probably present during the initial interpretation or whether the lesion was a “true interval” cancer. Results 77,445 participants were randomized to the intervention arm with 70,633 screened. Of 5227 positive screens from any screening round, 299 resulted in screen-detected lung cancers; 151 had potential interval cancers with 127 CXR available for re-review. Cancer was probably present in 45/127 (35.4%) at time of screening; 82 (64.6%) were “true interval” cancers. Compared to screen-detected cancers, true interval cancers were more common among males, persons with <12 years education and those with a history of smoking. True interval lung cancers were more often small cell, 28.1% vs. 7.4%, and less often adenocarcinoma, 25.6% vs. 56.2% ( p < 0.001), more advanced stage IV (30.5% vs. 16.6%, p < 0.02), and less likely to be in the right upper lobe, 17.1% vs. 36.1% ( p < 0.02). Conclusion True interval lung cancers differ from CXR-screen-detected cancers with regard to demographic variables, stage, cell type and location. ClinicalTrials.gov number: NCT00002540.</description><identifier>ISSN: 0169-5002</identifier><identifier>ISSN: 1872-8332</identifier><identifier>EISSN: 1872-8332</identifier><identifier>DOI: 10.1016/j.lungcan.2014.07.013</identifier><identifier>PMID: 25123333</identifier><identifier>CODEN: LUCAE5</identifier><language>eng</language><publisher>Oxford: Elsevier Ireland Ltd</publisher><subject>Aged ; Biological and medical sciences ; Chest radiograph ; Chest X-ray screen-detected lung cancers ; Female ; Hematology, Oncology and Palliative Medicine ; Humans ; Lung cancer ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - pathology ; Male ; Mass Chest X-Ray ; Medical sciences ; Middle Aged ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasm Grading ; Neoplasm Staging ; Odds Ratio ; PLCO Cancer Screening Trial ; Pneumology ; Pulmonary tumour ; Pulmonary/Respiratory ; Risk Factors ; Screening interval lung cancers ; Sensitivity and Specificity ; Tumors ; Tumors of the respiratory system and mediastinum</subject><ispartof>Lung cancer (Amsterdam, Netherlands), 2014-10, Vol.86 (1), p.41-46</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2014 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.</rights><rights>2014 Elsevier Ltd. All rights reserved. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c622t-619ef2c81c2f0b7fc9aab773146bae439a81072c7ca6266baed1e6309d1f593d3</citedby><cites>FETCH-LOGICAL-c622t-619ef2c81c2f0b7fc9aab773146bae439a81072c7ca6266baed1e6309d1f593d3</cites><orcidid>0000-0002-2966-4391</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0169500214003134$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28811093$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25123333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kvale, Paul A</creatorcontrib><creatorcontrib>Johnson, Christine Cole</creatorcontrib><creatorcontrib>Tammemägi, Martin</creatorcontrib><creatorcontrib>Marcus, Pamela M</creatorcontrib><creatorcontrib>Zylak, Carl J</creatorcontrib><creatorcontrib>Spizarny, David L</creatorcontrib><creatorcontrib>Hocking, William</creatorcontrib><creatorcontrib>Oken, Martin</creatorcontrib><creatorcontrib>Commins, John</creatorcontrib><creatorcontrib>Ragard, Lawrence</creatorcontrib><creatorcontrib>Hu, Ping</creatorcontrib><creatorcontrib>Berg, Christine</creatorcontrib><creatorcontrib>Prorok, Philip</creatorcontrib><title>Interval lung cancers not detected on screening chest X-rays: How are they different?</title><title>Lung cancer (Amsterdam, Netherlands)</title><addtitle>Lung Cancer</addtitle><description>Abstract Background The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial provides us an opportunity to describe interval lung cancers not detected by screening chest X-ray (CXR) compared to screen-detected cancers. Methods Participants were screened for lung cancer with CXR at baseline and annually for two (never smokers) or three (ever smokers) more years. Screen-detected cancers were those with a positive CXR and diagnosed within 12 months. Putative interval cancers were those with a negative CXR screen but with a diagnosis of lung cancer within 12 months. Potential interval cancers were re-reviewed to determine whether lung cancer was missed and probably present during the initial interpretation or whether the lesion was a “true interval” cancer. Results 77,445 participants were randomized to the intervention arm with 70,633 screened. Of 5227 positive screens from any screening round, 299 resulted in screen-detected lung cancers; 151 had potential interval cancers with 127 CXR available for re-review. Cancer was probably present in 45/127 (35.4%) at time of screening; 82 (64.6%) were “true interval” cancers. Compared to screen-detected cancers, true interval cancers were more common among males, persons with <12 years education and those with a history of smoking. True interval lung cancers were more often small cell, 28.1% vs. 7.4%, and less often adenocarcinoma, 25.6% vs. 56.2% ( p < 0.001), more advanced stage IV (30.5% vs. 16.6%, p < 0.02), and less likely to be in the right upper lobe, 17.1% vs. 36.1% ( p < 0.02). Conclusion True interval lung cancers differ from CXR-screen-detected cancers with regard to demographic variables, stage, cell type and location. ClinicalTrials.gov number: NCT00002540.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chest radiograph</subject><subject>Chest X-ray screen-detected lung cancers</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Mass Chest X-Ray</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Staging</subject><subject>Odds Ratio</subject><subject>PLCO Cancer Screening Trial</subject><subject>Pneumology</subject><subject>Pulmonary tumour</subject><subject>Pulmonary/Respiratory</subject><subject>Risk Factors</subject><subject>Screening interval lung cancers</subject><subject>Sensitivity and Specificity</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0169-5002</issn><issn>1872-8332</issn><issn>1872-8332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9vFCEUx4nR2LX6J2i4mHiZkQfz00ObplHbpIkHbeLthWXedFlnocLMmv3vZbJrW3spFxL48H0PPjD2FkQOAqqP63yY3I3RLpcCilzUuQD1jC2gqWXWKCWfs0Xi2qwUQh6xVzGuhYAaRPuSHckSpEpjwa4v3Uhhqwc-x_GUZyhE7vzIOxrJjNRx73g0gcjZmVhRHPnPLOhd_MQv_B-uA_FxRTve2b6nQG48fc1e9HqI9OYwH7PrL59_nF9kV9--Xp6fXWWmknLMKmipl6YBI3uxrHvTar2sawVFtdRUqFY3IGppaqMrWc1rHVClRNtBX7aqU8fsZJ97Oy031JlUO-gBb4Pd6LBDry3-v-PsCm_8FguppBIyBXw4BAT_e0o3w42NhoZBO_JTRCirQpWqKYuElnvUBB9joP6uDAicleAaD0pwVoKixqQknXv3sMe7U_8cJOD9AdDR6KEPyYGN91zTQLI2c6d7jtKLbi0FjMZS8tXZkERh5-2TrZw8SjCDdTYV_UU7ims_BZd0IWCUKPD7_H_m7wOFEApUof4CwYvCeA</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Kvale, Paul A</creator><creator>Johnson, Christine Cole</creator><creator>Tammemägi, Martin</creator><creator>Marcus, Pamela M</creator><creator>Zylak, Carl J</creator><creator>Spizarny, David L</creator><creator>Hocking, William</creator><creator>Oken, Martin</creator><creator>Commins, John</creator><creator>Ragard, Lawrence</creator><creator>Hu, Ping</creator><creator>Berg, Christine</creator><creator>Prorok, Philip</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2966-4391</orcidid></search><sort><creationdate>20141001</creationdate><title>Interval lung cancers not detected on screening chest X-rays: How are they different?</title><author>Kvale, Paul A ; Johnson, Christine Cole ; Tammemägi, Martin ; Marcus, Pamela M ; Zylak, Carl J ; Spizarny, David L ; Hocking, William ; Oken, Martin ; Commins, John ; Ragard, Lawrence ; Hu, Ping ; Berg, Christine ; Prorok, Philip</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-619ef2c81c2f0b7fc9aab773146bae439a81072c7ca6266baed1e6309d1f593d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chest radiograph</topic><topic>Chest X-ray screen-detected lung cancers</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Mass Chest X-Ray</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Staging</topic><topic>Odds Ratio</topic><topic>PLCO Cancer Screening Trial</topic><topic>Pneumology</topic><topic>Pulmonary tumour</topic><topic>Pulmonary/Respiratory</topic><topic>Risk Factors</topic><topic>Screening interval lung cancers</topic><topic>Sensitivity and Specificity</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kvale, Paul A</creatorcontrib><creatorcontrib>Johnson, Christine Cole</creatorcontrib><creatorcontrib>Tammemägi, Martin</creatorcontrib><creatorcontrib>Marcus, Pamela M</creatorcontrib><creatorcontrib>Zylak, Carl J</creatorcontrib><creatorcontrib>Spizarny, David L</creatorcontrib><creatorcontrib>Hocking, William</creatorcontrib><creatorcontrib>Oken, Martin</creatorcontrib><creatorcontrib>Commins, John</creatorcontrib><creatorcontrib>Ragard, Lawrence</creatorcontrib><creatorcontrib>Hu, Ping</creatorcontrib><creatorcontrib>Berg, Christine</creatorcontrib><creatorcontrib>Prorok, Philip</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kvale, Paul A</au><au>Johnson, Christine Cole</au><au>Tammemägi, Martin</au><au>Marcus, Pamela M</au><au>Zylak, Carl J</au><au>Spizarny, David L</au><au>Hocking, William</au><au>Oken, Martin</au><au>Commins, John</au><au>Ragard, Lawrence</au><au>Hu, Ping</au><au>Berg, Christine</au><au>Prorok, Philip</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interval lung cancers not detected on screening chest X-rays: How are they different?</atitle><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle><addtitle>Lung Cancer</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>86</volume><issue>1</issue><spage>41</spage><epage>46</epage><pages>41-46</pages><issn>0169-5002</issn><issn>1872-8332</issn><eissn>1872-8332</eissn><coden>LUCAE5</coden><abstract>Abstract Background The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial provides us an opportunity to describe interval lung cancers not detected by screening chest X-ray (CXR) compared to screen-detected cancers. Methods Participants were screened for lung cancer with CXR at baseline and annually for two (never smokers) or three (ever smokers) more years. Screen-detected cancers were those with a positive CXR and diagnosed within 12 months. Putative interval cancers were those with a negative CXR screen but with a diagnosis of lung cancer within 12 months. Potential interval cancers were re-reviewed to determine whether lung cancer was missed and probably present during the initial interpretation or whether the lesion was a “true interval” cancer. Results 77,445 participants were randomized to the intervention arm with 70,633 screened. Of 5227 positive screens from any screening round, 299 resulted in screen-detected lung cancers; 151 had potential interval cancers with 127 CXR available for re-review. Cancer was probably present in 45/127 (35.4%) at time of screening; 82 (64.6%) were “true interval” cancers. Compared to screen-detected cancers, true interval cancers were more common among males, persons with <12 years education and those with a history of smoking. True interval lung cancers were more often small cell, 28.1% vs. 7.4%, and less often adenocarcinoma, 25.6% vs. 56.2% ( p < 0.001), more advanced stage IV (30.5% vs. 16.6%, p < 0.02), and less likely to be in the right upper lobe, 17.1% vs. 36.1% ( p < 0.02). Conclusion True interval lung cancers differ from CXR-screen-detected cancers with regard to demographic variables, stage, cell type and location. ClinicalTrials.gov number: NCT00002540.</abstract><cop>Oxford</cop><pub>Elsevier Ireland Ltd</pub><pmid>25123333</pmid><doi>10.1016/j.lungcan.2014.07.013</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-2966-4391</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biological and medical sciences Chest radiograph Chest X-ray screen-detected lung cancers Female Hematology, Oncology and Palliative Medicine Humans Lung cancer Lung Neoplasms - diagnostic imaging Lung Neoplasms - pathology Male Mass Chest X-Ray Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Grading Neoplasm Staging Odds Ratio PLCO Cancer Screening Trial Pneumology Pulmonary tumour Pulmonary/Respiratory Risk Factors Screening interval lung cancers Sensitivity and Specificity Tumors Tumors of the respiratory system and mediastinum |
| title | Interval lung cancers not detected on screening chest X-rays: How are they different? |
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