Antiretroviral therapy in HIV-infected elite controllers: impact on gut immunology, microbial translocation, and biomarkers of serious non-AIDS conditions
Elite controllers (ECs) maintain undetectable HIV viral loads without antiretroviral therapy (ART) but are at increased risk of serious non-AIDS conditions (SNA). We assessed the impact of ART in ECs on gut immune dysfunction and biomarkers predicting SNA (blood CD4/CD8 ratio, plasma IL-6, D-dimer l...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2014-12, Vol.67 (5), p.514-518 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
| container_volume | 67 |
| creator | Kim, Connie J Kovacs, Colin Chun, Tae-Wook Kandel, Gabor Osborne, Brendan J W Huibner, Sanja Shahabi, Kamnoosh Yue, Feng-Yun Benko, Erika Ostowski, Mario Kaul, Rupert |
| description | Elite controllers (ECs) maintain undetectable HIV viral loads without antiretroviral therapy (ART) but are at increased risk of serious non-AIDS conditions (SNA). We assessed the impact of ART in ECs on gut immune dysfunction and biomarkers predicting SNA (blood CD4/CD8 ratio, plasma IL-6, D-dimer levels). At baseline, ECs had elevated IL-6 and D-dimer levels and reduced CD4/CD8 ratio compared with HIV-uninfected controls, but no difference in microbial translocation or gut CD4 subsets. ART increased CD4/CD8 ratio but did not normalize IL-6 and D-dimer levels. EC SNA pathogenesis may be independent of gut immune dysfunction, and resolution may require prolonged ART. |
| doi_str_mv | 10.1097/QAI.0000000000000359 |
| format | Article |
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EC SNA pathogenesis may be independent of gut immune dysfunction, and resolution may require prolonged ART.</description><subject>Adult</subject><subject>Aged</subject><subject>AIDS/HIV</subject><subject>Anti-Retroviral Agents - therapeutic use</subject><subject>Antiretroviral Therapy, Highly Active - methods</subject><subject>Bacterial Translocation</subject><subject>Biomarkers</subject><subject>CD4-CD8 Ratio</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - analysis</subject><subject>Gastrointestinal Tract - immunology</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Long-Term Survivors</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Middle Aged</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUdtO3DAQtapWBbb9A4T82AdCfYsT96HSikJZCQlVhb5GjjO7GBw7tR2k_RW-tl4VEMw8zIzm6Jy5IHRIyQklqvn6a7k6Ia-N1-od2qdKiKppW_G-5DWrK0F5vYcOUrojhEoh1Ee0x2qudr6PHpc-2wg5hgcbtcP5FqKetth6fLH6U1m_BpNhwOBsBmyCL0jnIKZv2I6TNhkHjzdzLtU4--DCZnuMR2ti6O2OLmqfXDA62-CPsfYD7m0YdbwvFDiscYJow5ywD75arn783kkMdodOn9CHtXYJPj_FBbo5P7s-vagur36uTpeX1cSkzJVoDB24boQ2a5DCENMroQamJZGDUrpmrKWKQlMzKmsBgvVccKZaJoUilPIF-v6fd5r7EQYDZUftuinaMue2C9p2bzve3nab8NAJxmlbTrlAX54IYvg7Q8rdaJMB57SHsltHZQEJ0hBRoEevtV5Enh_C_wGg4pGq</recordid><startdate>20141215</startdate><enddate>20141215</enddate><creator>Kim, Connie J</creator><creator>Kovacs, Colin</creator><creator>Chun, Tae-Wook</creator><creator>Kandel, Gabor</creator><creator>Osborne, Brendan J W</creator><creator>Huibner, Sanja</creator><creator>Shahabi, Kamnoosh</creator><creator>Yue, Feng-Yun</creator><creator>Benko, Erika</creator><creator>Ostowski, Mario</creator><creator>Kaul, Rupert</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141215</creationdate><title>Antiretroviral therapy in HIV-infected elite controllers: impact on gut immunology, microbial translocation, and biomarkers of serious non-AIDS conditions</title><author>Kim, Connie J ; 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| ispartof | Journal of acquired immune deficiency syndromes (1999), 2014-12, Vol.67 (5), p.514-518 |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Free E- Journals; Journals@Ovid Complete |
| subjects | Adult Aged AIDS/HIV Anti-Retroviral Agents - therapeutic use Antiretroviral Therapy, Highly Active - methods Bacterial Translocation Biomarkers CD4-CD8 Ratio Female Fibrin Fibrinogen Degradation Products - analysis Gastrointestinal Tract - immunology HIV Infections - complications HIV Infections - drug therapy HIV Long-Term Survivors Humans Interleukin-6 - blood Male Middle Aged |
| title | Antiretroviral therapy in HIV-infected elite controllers: impact on gut immunology, microbial translocation, and biomarkers of serious non-AIDS conditions |
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