Growth hormone receptor signaling is dispensable for HSC function and aging

Growth hormone receptor (Ghr) signaling is important in a wide variety of cellular processes including aging; however, the role of Ghr signaling in hematopoietic stem cell (HSC) biology remains unexplored. Within the hematopoietic system, Ghr is expressed in a highly HSC-specific manner and is signi...

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Veröffentlicht in:	Blood 2014-11, Vol.124 (20), p.3076-3080
Hauptverfasser:	Stewart, Morag H., Gutierrez-Martinez, Paula, Beerman, Isabel, Garrison, Brian, Gallagher, Emily J., LeRoith, Derek, Rossi, Derrick J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Brief Report Cellular Senescence Gene Deletion Gene Expression Growth Hormone - administration & dosage Growth Hormone - metabolism Hematopoiesis Hematopoiesis and Stem Cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Mice Receptors, Somatotropin - genetics Receptors, Somatotropin - metabolism Signal Transduction
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