Endocytic trafficking of laminin is controlled by dystroglycan and is disrupted in cancers

The dynamic interactions between cells and basement membranes serve as essential regulators of tissue architecture and function in metazoans, and perturbation of these interactions contributes to the progression of a wide range of human diseases, including cancers. Here, we reveal the pathway and me...

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Veröffentlicht in:	Journal of cell science 2014-11, Vol.127 (Pt 22), p.4894-4903
Hauptverfasser:	Leonoudakis, Dmitri, Huang, Ge, Akhavan, Armin, Fata, Jimmie E, Singh, Manisha, Gray, Joe W, Muschler, John L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basement Membrane - metabolism Dystroglycans - metabolism Endocytosis Female Humans Laminin - metabolism Mammary Glands, Animal - cytology Mammary Glands, Animal - metabolism Mammary Glands, Human - cytology Mammary Glands, Human - metabolism Mice Mice, Knockout Neoplasms - metabolism Pregnancy
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