Time-resolved fluorescence lifetime for cutaneous melanoma detection

Time-resolved fluorescence lifetime for cutaneous melanoma detection

Melanoma is the most aggressive skin cancer type. It is characterized by pigmented lesions with high tissue invasion and metastatic potential. The early detection of melanoma is extremely important to improve patient prognosis and survival rate, since it can progress to the deadly metastatic stage....

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Veröffentlicht in:Biomedical optics express 2014-09, Vol.5 (9), p.3080-3089
Hauptverfasser: Pires, Layla, Nogueira, Marcelo Saito, Pratavieira, Sebastião, Moriyama, Lilian Tan, Kurachi, Cristina
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container_issue 9
container_start_page 3080
container_title Biomedical optics express
container_volume 5
creator Pires, Layla
Nogueira, Marcelo Saito
Pratavieira, Sebastião
Moriyama, Lilian Tan
Kurachi, Cristina
description Melanoma is the most aggressive skin cancer type. It is characterized by pigmented lesions with high tissue invasion and metastatic potential. The early detection of melanoma is extremely important to improve patient prognosis and survival rate, since it can progress to the deadly metastatic stage. Presently, the melanoma diagnosis is based on the clinical analysis of the macroscopic lesion characteristics such as shape, color, borders following the ABCD rules. The aim of this study is to evaluate the time-resolved fluorescence lifetime of NADH and FAD molecules to detect cutaneous melanoma in an experimental in vivo model. Forty-two lesions were analyzed and the data was classified using linear discriminant analysis, a sensitivity of 99.4%, specificity of 97.4% and accuracy of 98.4% were achieved. These results show the potential of this fluorescence spectroscopy for melanoma detection.
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title Time-resolved fluorescence lifetime for cutaneous melanoma detection
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