The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells

Human Period 2 (hPer2) is a transcriptional regulator at the core of the circadian clock mechanism that is responsible for generating the negative feedback loop that sustains the clock. Its relevance to human disease is underlined by alterations in its function that affect numerous biochemical and p...

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Veröffentlicht in:	Molecular biology of the cell 2014-10, Vol.25 (19), p.3081-3093
Hauptverfasser:	Gotoh, Tetsuya, Vila-Caballer, Marian, Santos, Carlo S, Liu, Jingjing, Yang, Jianhua, Finkielstein, Carla V
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - genetics Biomarkers, Tumor - genetics Cell Cycle Proteins - genetics Circadian Clocks - genetics Circadian Rhythm - genetics Cyclin-Dependent Kinase Inhibitor p21 - genetics DNA Damage DNA Repair Exoribonucleases - genetics Gene Expression Regulation HCT116 Cells Humans Multiprotein Complexes - metabolism Nuclear Proteins - genetics Period Circadian Proteins - biosynthesis Period Circadian Proteins - metabolism Protein Binding Proto-Oncogene Proteins c-mdm2 - metabolism Transcription, Genetic Transcriptional Activation - genetics Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Ubiquitination
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