Radiotherapy for gastric lymphoma: a planning study of 3D conformal radiotherapy, the half-beam method, and intensity-modulated radiotherapy
During radiotherapy for gastric lymphoma, it is difficult to protect the liver and kidneys in cases where there is considerable overlap between these organs and the target volume. This study was conducted to compare the three radiotherapy planning techniques of four-fields 3D conformal radiotherapy...
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| Veröffentlicht in: | Journal of radiation research 2014-11, Vol.55 (6), p.1141-1145 |
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| creator | Inaba, Koji Okamoto, Hiroyuki Wakita, Akihisa Nakamura, Satoshi Kobayashi, Kazuma Harada, Ken Kitaguchi, Mayuka Sekii, Shuhei Takahashi, Kana Yoshio, Kotaro Murakami, Naoya Morota, Madoka Ito, Yoshinori Sumi, Minako Uno, Takashi Itami, Jun |
| description | During radiotherapy for gastric lymphoma, it is difficult to protect the liver and kidneys in cases where there is considerable overlap between these organs and the target volume. This study was conducted to compare the three radiotherapy planning techniques of four-fields 3D conformal radiotherapy (3DCRT), half-field radiotherapy (the half-beam method) and intensity-modulated radiotherapy (IMRT) used to treat primary gastric lymphoma in which the planning target volume (PTV) had a large overlap with the left kidney. A total of 17 patients with gastric diffuse large B-cell lymphoma (DLBCL) were included. In DLBCL, immunochemotherapy (Rituximab + CHOP) was followed by radiotherapy of 40 Gy to the whole stomach and peri-gastric lymph nodes. 3DCRT, the half-field method, and IMRT were compared with respect to the dose–volume histogram (DVH) parameters and generalized equivalent uniform dose (gEUD) to the kidneys, liver and PTV. The mean dose and gEUD for 3DCRT was higher than for IMRT and the half-beam method in the left kidney and both kidneys. The mean dose and gEUD of the left kidney was 2117 cGy and 2224 cGy for 3DCRT, 1520 cGy and 1637 cGy for IMRT, and 1100 cGy and 1357 cGy for the half-beam method, respectively. The mean dose and gEUD of both kidneys was 1335 cGy and 1559 cGy for 3DCRT, 1184 cGy and 1311 cGy for IMRT, and 700 cGy and 937 cGy for the half-beam method, respectively. Dose–volume histograms (DVHs) of the liver revealed a larger volume was irradiated in the dose range 25 Gy). IMRT and the half-beam method had the advantages of dose reduction for the kidneys and liver. |
| doi_str_mv | 10.1093/jrr/rru052 |
| format | Article |
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This study was conducted to compare the three radiotherapy planning techniques of four-fields 3D conformal radiotherapy (3DCRT), half-field radiotherapy (the half-beam method) and intensity-modulated radiotherapy (IMRT) used to treat primary gastric lymphoma in which the planning target volume (PTV) had a large overlap with the left kidney. A total of 17 patients with gastric diffuse large B-cell lymphoma (DLBCL) were included. In DLBCL, immunochemotherapy (Rituximab + CHOP) was followed by radiotherapy of 40 Gy to the whole stomach and peri-gastric lymph nodes. 3DCRT, the half-field method, and IMRT were compared with respect to the dose–volume histogram (DVH) parameters and generalized equivalent uniform dose (gEUD) to the kidneys, liver and PTV. The mean dose and gEUD for 3DCRT was higher than for IMRT and the half-beam method in the left kidney and both kidneys. The mean dose and gEUD of the left kidney was 2117 cGy and 2224 cGy for 3DCRT, 1520 cGy and 1637 cGy for IMRT, and 1100 cGy and 1357 cGy for the half-beam method, respectively. The mean dose and gEUD of both kidneys was 1335 cGy and 1559 cGy for 3DCRT, 1184 cGy and 1311 cGy for IMRT, and 700 cGy and 937 cGy for the half-beam method, respectively. Dose–volume histograms (DVHs) of the liver revealed a larger volume was irradiated in the dose range <25 Gy with 3DCRT, while the half-beam method irradiated a larger volume of liver with the higher dose range (>25 Gy). IMRT and the half-beam method had the advantages of dose reduction for the kidneys and liver.</description><identifier>ISSN: 0449-3060</identifier><identifier>EISSN: 1349-9157</identifier><identifier>DOI: 10.1093/jrr/rru052</identifier><identifier>PMID: 25161174</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Antibodies, Monoclonal, Murine-Derived - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Combined Modality Therapy ; Cyclophosphamide - therapeutic use ; Diffusion ; Doxorubicin - therapeutic use ; Humans ; Kidney - radiation effects ; Kidneys ; Liver ; Liver - radiation effects ; Lymph ; Lymphoma, Large B-Cell, Diffuse - radiotherapy ; Lymphoma, Large B-Cell, Diffuse - therapy ; Lymphomas ; Methods ; Oncology ; Organs at Risk - radiation effects ; Patients ; Prednisone - therapeutic use ; Radiotherapy ; Radiotherapy Planning, Computer-Assisted - methods ; Radiotherapy, Conformal - adverse effects ; Radiotherapy, Conformal - methods ; Radiotherapy, Intensity-Modulated - adverse effects ; Radiotherapy, Intensity-Modulated - methods ; Rituximab ; Stomach ; Stomach Neoplasms - radiotherapy ; Stomach Neoplasms - therapy ; Three dimensional ; Vincristine - therapeutic use</subject><ispartof>Journal of radiation research, 2014-11, Vol.55 (6), p.1141-1145</ispartof><rights>The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. 2014</rights><rights>The Author 2014. 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This study was conducted to compare the three radiotherapy planning techniques of four-fields 3D conformal radiotherapy (3DCRT), half-field radiotherapy (the half-beam method) and intensity-modulated radiotherapy (IMRT) used to treat primary gastric lymphoma in which the planning target volume (PTV) had a large overlap with the left kidney. A total of 17 patients with gastric diffuse large B-cell lymphoma (DLBCL) were included. In DLBCL, immunochemotherapy (Rituximab + CHOP) was followed by radiotherapy of 40 Gy to the whole stomach and peri-gastric lymph nodes. 3DCRT, the half-field method, and IMRT were compared with respect to the dose–volume histogram (DVH) parameters and generalized equivalent uniform dose (gEUD) to the kidneys, liver and PTV. The mean dose and gEUD for 3DCRT was higher than for IMRT and the half-beam method in the left kidney and both kidneys. The mean dose and gEUD of the left kidney was 2117 cGy and 2224 cGy for 3DCRT, 1520 cGy and 1637 cGy for IMRT, and 1100 cGy and 1357 cGy for the half-beam method, respectively. The mean dose and gEUD of both kidneys was 1335 cGy and 1559 cGy for 3DCRT, 1184 cGy and 1311 cGy for IMRT, and 700 cGy and 937 cGy for the half-beam method, respectively. Dose–volume histograms (DVHs) of the liver revealed a larger volume was irradiated in the dose range <25 Gy with 3DCRT, while the half-beam method irradiated a larger volume of liver with the higher dose range (>25 Gy). IMRT and the half-beam method had the advantages of dose reduction for the kidneys and liver.</description><subject>Antibodies, Monoclonal, Murine-Derived - therapeutic use</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Combined Modality Therapy</subject><subject>Cyclophosphamide - therapeutic use</subject><subject>Diffusion</subject><subject>Doxorubicin - therapeutic use</subject><subject>Humans</subject><subject>Kidney - radiation effects</subject><subject>Kidneys</subject><subject>Liver</subject><subject>Liver - radiation effects</subject><subject>Lymph</subject><subject>Lymphoma, Large B-Cell, Diffuse - radiotherapy</subject><subject>Lymphoma, Large B-Cell, Diffuse - therapy</subject><subject>Lymphomas</subject><subject>Methods</subject><subject>Oncology</subject><subject>Organs at Risk - radiation effects</subject><subject>Patients</subject><subject>Prednisone - therapeutic use</subject><subject>Radiotherapy</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>Radiotherapy, Conformal - adverse effects</subject><subject>Radiotherapy, Conformal - methods</subject><subject>Radiotherapy, Intensity-Modulated - adverse effects</subject><subject>Radiotherapy, Intensity-Modulated - methods</subject><subject>Rituximab</subject><subject>Stomach</subject><subject>Stomach Neoplasms - radiotherapy</subject><subject>Stomach Neoplasms - therapy</subject><subject>Three dimensional</subject><subject>Vincristine - therapeutic use</subject><issn>0449-3060</issn><issn>1349-9157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkttqFTEUhoModlu98QEkIEKRTpvTTHa8EEo9QkEQvQ6ZHPakzEymSUaYd-hDm83U0g0ikosskm_9i_z5AXiJ0RlGgp5fx3ge44xq8ghsMGWiErjmj8EGsVJT1KAj8Cyla4QIRzV6Co5IjRuMOduA2-_K-JA7G9W0QBci3KmUo9ewX4apC4N6BxWcejWOftzBlGezwOAg_QB1GAs_qB7GBxqnsBSwU72rWqsGONjcBXMK1WigH7Mdk89LNQQz9ypbc9D7HDxxqk_2xd1-DH5--vjj8kt19e3z18uLq0pzxHLFasYd57XVLSHcMIFaSl2jsbMCWdcKR8xWcau0EYzTbWsINaQhvGnbdksYPQbvV91pbgdrtB1zVL2coh9UXGRQXh7ejL6Tu_BLMkKEwLwInNwJxHAz25Tl4JO2fbHJhjlJzLcN3mLS_A9aY4IoFk1BX6_oTvVW-uJuGa73uLyoaYNrytmeOvsLVZaxgy9_Yp0v5wcNb9cGHUNK0br7h2Ik9wGSJUByDVCBXz205h79k5gCvFmBME__EvoNUVLRTg</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Inaba, Koji</creator><creator>Okamoto, Hiroyuki</creator><creator>Wakita, Akihisa</creator><creator>Nakamura, Satoshi</creator><creator>Kobayashi, Kazuma</creator><creator>Harada, Ken</creator><creator>Kitaguchi, Mayuka</creator><creator>Sekii, Shuhei</creator><creator>Takahashi, Kana</creator><creator>Yoshio, Kotaro</creator><creator>Murakami, Naoya</creator><creator>Morota, Madoka</creator><creator>Ito, Yoshinori</creator><creator>Sumi, Minako</creator><creator>Uno, Takashi</creator><creator>Itami, Jun</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20141101</creationdate><title>Radiotherapy for gastric lymphoma: a planning study of 3D conformal radiotherapy, the half-beam method, and intensity-modulated radiotherapy</title><author>Inaba, Koji ; Okamoto, Hiroyuki ; Wakita, Akihisa ; Nakamura, Satoshi ; Kobayashi, Kazuma ; Harada, Ken ; Kitaguchi, Mayuka ; Sekii, Shuhei ; Takahashi, Kana ; Yoshio, Kotaro ; Murakami, Naoya ; Morota, Madoka ; Ito, Yoshinori ; Sumi, Minako ; Uno, Takashi ; Itami, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c704t-4547f775ecb227d490b33f6c1fe90efb9f2d8a7eacd94738bd23d26276bbb8243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antibodies, Monoclonal, Murine-Derived - therapeutic use</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Combined Modality Therapy</topic><topic>Cyclophosphamide - therapeutic use</topic><topic>Diffusion</topic><topic>Doxorubicin - therapeutic use</topic><topic>Humans</topic><topic>Kidney - radiation effects</topic><topic>Kidneys</topic><topic>Liver</topic><topic>Liver - radiation effects</topic><topic>Lymph</topic><topic>Lymphoma, Large B-Cell, Diffuse - radiotherapy</topic><topic>Lymphoma, Large B-Cell, Diffuse - therapy</topic><topic>Lymphomas</topic><topic>Methods</topic><topic>Oncology</topic><topic>Organs at Risk - radiation effects</topic><topic>Patients</topic><topic>Prednisone - therapeutic use</topic><topic>Radiotherapy</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>Radiotherapy, Conformal - adverse effects</topic><topic>Radiotherapy, Conformal - methods</topic><topic>Radiotherapy, Intensity-Modulated - adverse effects</topic><topic>Radiotherapy, Intensity-Modulated - methods</topic><topic>Rituximab</topic><topic>Stomach</topic><topic>Stomach Neoplasms - radiotherapy</topic><topic>Stomach Neoplasms - therapy</topic><topic>Three dimensional</topic><topic>Vincristine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inaba, Koji</creatorcontrib><creatorcontrib>Okamoto, Hiroyuki</creatorcontrib><creatorcontrib>Wakita, Akihisa</creatorcontrib><creatorcontrib>Nakamura, Satoshi</creatorcontrib><creatorcontrib>Kobayashi, Kazuma</creatorcontrib><creatorcontrib>Harada, Ken</creatorcontrib><creatorcontrib>Kitaguchi, Mayuka</creatorcontrib><creatorcontrib>Sekii, Shuhei</creatorcontrib><creatorcontrib>Takahashi, Kana</creatorcontrib><creatorcontrib>Yoshio, Kotaro</creatorcontrib><creatorcontrib>Murakami, Naoya</creatorcontrib><creatorcontrib>Morota, Madoka</creatorcontrib><creatorcontrib>Ito, Yoshinori</creatorcontrib><creatorcontrib>Sumi, Minako</creatorcontrib><creatorcontrib>Uno, Takashi</creatorcontrib><creatorcontrib>Itami, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Inaba, Koji</au><au>Okamoto, Hiroyuki</au><au>Wakita, Akihisa</au><au>Nakamura, Satoshi</au><au>Kobayashi, Kazuma</au><au>Harada, Ken</au><au>Kitaguchi, Mayuka</au><au>Sekii, Shuhei</au><au>Takahashi, Kana</au><au>Yoshio, Kotaro</au><au>Murakami, Naoya</au><au>Morota, Madoka</au><au>Ito, Yoshinori</au><au>Sumi, Minako</au><au>Uno, Takashi</au><au>Itami, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiotherapy for gastric lymphoma: a planning study of 3D conformal radiotherapy, the half-beam method, and intensity-modulated radiotherapy</atitle><jtitle>Journal of radiation research</jtitle><addtitle>J Radiat Res</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>55</volume><issue>6</issue><spage>1141</spage><epage>1145</epage><pages>1141-1145</pages><issn>0449-3060</issn><eissn>1349-9157</eissn><abstract>During radiotherapy for gastric lymphoma, it is difficult to protect the liver and kidneys in cases where there is considerable overlap between these organs and the target volume. This study was conducted to compare the three radiotherapy planning techniques of four-fields 3D conformal radiotherapy (3DCRT), half-field radiotherapy (the half-beam method) and intensity-modulated radiotherapy (IMRT) used to treat primary gastric lymphoma in which the planning target volume (PTV) had a large overlap with the left kidney. A total of 17 patients with gastric diffuse large B-cell lymphoma (DLBCL) were included. In DLBCL, immunochemotherapy (Rituximab + CHOP) was followed by radiotherapy of 40 Gy to the whole stomach and peri-gastric lymph nodes. 3DCRT, the half-field method, and IMRT were compared with respect to the dose–volume histogram (DVH) parameters and generalized equivalent uniform dose (gEUD) to the kidneys, liver and PTV. The mean dose and gEUD for 3DCRT was higher than for IMRT and the half-beam method in the left kidney and both kidneys. The mean dose and gEUD of the left kidney was 2117 cGy and 2224 cGy for 3DCRT, 1520 cGy and 1637 cGy for IMRT, and 1100 cGy and 1357 cGy for the half-beam method, respectively. The mean dose and gEUD of both kidneys was 1335 cGy and 1559 cGy for 3DCRT, 1184 cGy and 1311 cGy for IMRT, and 700 cGy and 937 cGy for the half-beam method, respectively. Dose–volume histograms (DVHs) of the liver revealed a larger volume was irradiated in the dose range <25 Gy with 3DCRT, while the half-beam method irradiated a larger volume of liver with the higher dose range (>25 Gy). IMRT and the half-beam method had the advantages of dose reduction for the kidneys and liver.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>25161174</pmid><doi>10.1093/jrr/rru052</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of radiation research, 2014-11, Vol.55 (6), p.1141-1145 |
| issn | 0449-3060 1349-9157 |
| language | eng |
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| source | Oxford Journals Open Access Collection |
| subjects | Antibodies, Monoclonal, Murine-Derived - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Combined Modality Therapy Cyclophosphamide - therapeutic use Diffusion Doxorubicin - therapeutic use Humans Kidney - radiation effects Kidneys Liver Liver - radiation effects Lymph Lymphoma, Large B-Cell, Diffuse - radiotherapy Lymphoma, Large B-Cell, Diffuse - therapy Lymphomas Methods Oncology Organs at Risk - radiation effects Patients Prednisone - therapeutic use Radiotherapy Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Conformal - adverse effects Radiotherapy, Conformal - methods Radiotherapy, Intensity-Modulated - adverse effects Radiotherapy, Intensity-Modulated - methods Rituximab Stomach Stomach Neoplasms - radiotherapy Stomach Neoplasms - therapy Three dimensional Vincristine - therapeutic use |
| title | Radiotherapy for gastric lymphoma: a planning study of 3D conformal radiotherapy, the half-beam method, and intensity-modulated radiotherapy |
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