Co-morbidities are the key nominators of the health related quality of life in mild and moderate COPD
Co-morbidities are common in chronic obstructive pulmonary disease (COPD). We assessed the contribution of common co-morbidities on health related quality of life (HRQoL) among COPD patients. Using both generic (15D) and respiratory-specific (AQ20) instruments, HRQoL was assessed in a hospital based...
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| Veröffentlicht in: | BMC pulmonary medicine 2014-06, Vol.14 (1), p.102-102, Article 102 |
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| creator | Koskela, Jukka Kilpeläinen, Maritta Kupiainen, Henna Mazur, Witold Sintonen, Harri Boezen, Marike Lindqvist, Ari Postma, Dirkje Laitinen, Tarja |
| description | Co-morbidities are common in chronic obstructive pulmonary disease (COPD). We assessed the contribution of common co-morbidities on health related quality of life (HRQoL) among COPD patients.
Using both generic (15D) and respiratory-specific (AQ20) instruments, HRQoL was assessed in a hospital based COPD population (N = 739, 64% males, mean age 64 years, SD 7 years) in this observational study with inferential analysis. The prevalence of their co-morbidities was compared with those of 5000 population controls. The patients represented all severity stages of COPD and the patterns of common concomitant disorders differed between patients.
Co-morbidities such as psychiatric conditions, alcohol abuse, cardiovascular diseases, and diabetes were more common among COPD patients than in age and gender matched controls. Psychiatric conditions and alcohol abuse were the strongest determinants of HRQoL in COPD and could be detected by both 15D (Odds Ratio 4.7 and 2.3 respectively) and AQ20 (OR 2.0 and 3.0) instruments. Compared to respiratory specific AQ20, generic 15D was more sensitive to the effects of comorbidities while AQ20 was slightly more sensitive for the low FEV1. FEV1 was a strong determinant of HRQoL only at more severe stages of disease (FEV1 |
| doi_str_mv | 10.1186/1471-2466-14-102 |
| format | Article |
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Using both generic (15D) and respiratory-specific (AQ20) instruments, HRQoL was assessed in a hospital based COPD population (N = 739, 64% males, mean age 64 years, SD 7 years) in this observational study with inferential analysis. The prevalence of their co-morbidities was compared with those of 5000 population controls. The patients represented all severity stages of COPD and the patterns of common concomitant disorders differed between patients.
Co-morbidities such as psychiatric conditions, alcohol abuse, cardiovascular diseases, and diabetes were more common among COPD patients than in age and gender matched controls. Psychiatric conditions and alcohol abuse were the strongest determinants of HRQoL in COPD and could be detected by both 15D (Odds Ratio 4.7 and 2.3 respectively) and AQ20 (OR 2.0 and 3.0) instruments. Compared to respiratory specific AQ20, generic 15D was more sensitive to the effects of comorbidities while AQ20 was slightly more sensitive for the low FEV1. FEV1 was a strong determinant of HRQoL only at more severe stages of disease (FEV1 < 40% of predicted). Poor HRQoL also predicted death during the next five years.
The results suggest that co-morbidities may impair HRQoL at an early stage of the disease, while bronchial obstruction becomes a significant determinant of HRQoL only in severe COPD.</description><identifier>ISSN: 1471-2466</identifier><identifier>EISSN: 1471-2466</identifier><identifier>DOI: 10.1186/1471-2466-14-102</identifier><identifier>PMID: 24946786</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Acquisitions & mergers ; Aged ; Airway management ; Alcoholism - epidemiology ; Analysis ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Chronic obstructive pulmonary disease ; Clinical medicine ; Clinical trials ; Comorbidity ; Comparative analysis ; Diabetes Mellitus - epidemiology ; Drug therapy ; Family medical history ; Female ; Forced Expiratory Volume ; Gender ; Health aspects ; Health Status ; Hospitals ; Humans ; Lung diseases, Obstructive ; Male ; Medical research ; Medicine, Experimental ; Middle Aged ; Morbidity ; Mortality ; Patients ; Population ; Prevalence ; Public health ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Pulmonary Disease, Chronic Obstructive - mortality ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonology ; Quality of Life ; Questionnaires ; Sensitivity and Specificity ; Severity of Illness Index ; Statistical analysis ; Studies ; Surveys and Questionnaires</subject><ispartof>BMC pulmonary medicine, 2014-06, Vol.14 (1), p.102-102, Article 102</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Koskela et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Copyright © 2014 Koskela et al.; licensee BioMed Central Ltd. 2014 Koskela et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b617t-fa941c05e712ee4430165678224ac4b1e4f5a5f7b090ddf4577aed9dbdfc40293</citedby><cites>FETCH-LOGICAL-b617t-fa941c05e712ee4430165678224ac4b1e4f5a5f7b090ddf4577aed9dbdfc40293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229911/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229911/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24946786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koskela, Jukka</creatorcontrib><creatorcontrib>Kilpeläinen, Maritta</creatorcontrib><creatorcontrib>Kupiainen, Henna</creatorcontrib><creatorcontrib>Mazur, Witold</creatorcontrib><creatorcontrib>Sintonen, Harri</creatorcontrib><creatorcontrib>Boezen, Marike</creatorcontrib><creatorcontrib>Lindqvist, Ari</creatorcontrib><creatorcontrib>Postma, Dirkje</creatorcontrib><creatorcontrib>Laitinen, Tarja</creatorcontrib><title>Co-morbidities are the key nominators of the health related quality of life in mild and moderate COPD</title><title>BMC pulmonary medicine</title><addtitle>BMC Pulm Med</addtitle><description>Co-morbidities are common in chronic obstructive pulmonary disease (COPD). We assessed the contribution of common co-morbidities on health related quality of life (HRQoL) among COPD patients.
Using both generic (15D) and respiratory-specific (AQ20) instruments, HRQoL was assessed in a hospital based COPD population (N = 739, 64% males, mean age 64 years, SD 7 years) in this observational study with inferential analysis. The prevalence of their co-morbidities was compared with those of 5000 population controls. The patients represented all severity stages of COPD and the patterns of common concomitant disorders differed between patients.
Co-morbidities such as psychiatric conditions, alcohol abuse, cardiovascular diseases, and diabetes were more common among COPD patients than in age and gender matched controls. Psychiatric conditions and alcohol abuse were the strongest determinants of HRQoL in COPD and could be detected by both 15D (Odds Ratio 4.7 and 2.3 respectively) and AQ20 (OR 2.0 and 3.0) instruments. Compared to respiratory specific AQ20, generic 15D was more sensitive to the effects of comorbidities while AQ20 was slightly more sensitive for the low FEV1. FEV1 was a strong determinant of HRQoL only at more severe stages of disease (FEV1 < 40% of predicted). Poor HRQoL also predicted death during the next five years.
The results suggest that co-morbidities may impair HRQoL at an early stage of the disease, while bronchial obstruction becomes a significant determinant of HRQoL only in severe COPD.</description><subject>Acquisitions & mergers</subject><subject>Aged</subject><subject>Airway management</subject><subject>Alcoholism - epidemiology</subject><subject>Analysis</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Clinical medicine</subject><subject>Clinical trials</subject><subject>Comorbidity</subject><subject>Comparative analysis</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Drug therapy</subject><subject>Family medical history</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Gender</subject><subject>Health aspects</subject><subject>Health Status</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Lung diseases, Obstructive</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Patients</subject><subject>Population</subject><subject>Prevalence</subject><subject>Public health</subject><subject>Pulmonary Disease, Chronic Obstructive - epidemiology</subject><subject>Pulmonary Disease, Chronic Obstructive - mortality</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonology</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Surveys and Questionnaires</subject><issn>1471-2466</issn><issn>1471-2466</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1Ul1vFCEUJUZja_XdJ0Pi81RggFleTJrxM2lSH_SZMHDpUgdoGdZk_72sW9duUsMDN-eee3I4XIReU3JO6Uq-o3ygHeNSdpR3lLAn6PQAPX1Qn6AXy3JDCB1Won-OThhXXA4reYpgzF3MZQou1AALNgVwXQP-CVuccgzJ1FwWnP0fdA1mrmtcYDYVHL7bmDnU7a47Bw84JBzD7LBJDsfsoDQWHq--fXiJnnkzL_Dq_j5DPz59_D5-6S6vPn8dLy67SdKhdt4oTi0RMFAGwHlPqBTNJ2PcWD5R4F4Y4YeJKOKc52IYDDjlJuctJ0z1Z-j9Xvd2M0VwFlItZta3JURTtjqboI87Kaz1df6lOWNKUdoExr3AFPJ_BI47Nke9i1nvYm6Vbr_QVN7e2yj5bgNL1Td5U1J7uaaSSibUSpF_rGszgw7J56ZoY1isvhC9Eopx1jfW-SOsdhzEYHMCHxp-NED2A7bkZSngD-4p0buteczvm4exHQb-rkn_G-l_vKg</recordid><startdate>20140619</startdate><enddate>20140619</enddate><creator>Koskela, Jukka</creator><creator>Kilpeläinen, Maritta</creator><creator>Kupiainen, Henna</creator><creator>Mazur, Witold</creator><creator>Sintonen, Harri</creator><creator>Boezen, Marike</creator><creator>Lindqvist, Ari</creator><creator>Postma, Dirkje</creator><creator>Laitinen, Tarja</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20140619</creationdate><title>Co-morbidities are the key nominators of the health related quality of life in mild and moderate COPD</title><author>Koskela, Jukka ; Kilpeläinen, Maritta ; Kupiainen, Henna ; Mazur, Witold ; Sintonen, Harri ; Boezen, Marike ; Lindqvist, Ari ; Postma, Dirkje ; Laitinen, Tarja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b617t-fa941c05e712ee4430165678224ac4b1e4f5a5f7b090ddf4577aed9dbdfc40293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acquisitions & mergers</topic><topic>Aged</topic><topic>Airway management</topic><topic>Alcoholism - epidemiology</topic><topic>Analysis</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Clinical medicine</topic><topic>Clinical trials</topic><topic>Comorbidity</topic><topic>Comparative analysis</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Drug therapy</topic><topic>Family medical history</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Gender</topic><topic>Health aspects</topic><topic>Health Status</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Lung diseases, Obstructive</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Patients</topic><topic>Population</topic><topic>Prevalence</topic><topic>Public health</topic><topic>Pulmonary Disease, Chronic Obstructive - epidemiology</topic><topic>Pulmonary Disease, Chronic Obstructive - 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We assessed the contribution of common co-morbidities on health related quality of life (HRQoL) among COPD patients.
Using both generic (15D) and respiratory-specific (AQ20) instruments, HRQoL was assessed in a hospital based COPD population (N = 739, 64% males, mean age 64 years, SD 7 years) in this observational study with inferential analysis. The prevalence of their co-morbidities was compared with those of 5000 population controls. The patients represented all severity stages of COPD and the patterns of common concomitant disorders differed between patients.
Co-morbidities such as psychiatric conditions, alcohol abuse, cardiovascular diseases, and diabetes were more common among COPD patients than in age and gender matched controls. Psychiatric conditions and alcohol abuse were the strongest determinants of HRQoL in COPD and could be detected by both 15D (Odds Ratio 4.7 and 2.3 respectively) and AQ20 (OR 2.0 and 3.0) instruments. Compared to respiratory specific AQ20, generic 15D was more sensitive to the effects of comorbidities while AQ20 was slightly more sensitive for the low FEV1. FEV1 was a strong determinant of HRQoL only at more severe stages of disease (FEV1 < 40% of predicted). Poor HRQoL also predicted death during the next five years.
The results suggest that co-morbidities may impair HRQoL at an early stage of the disease, while bronchial obstruction becomes a significant determinant of HRQoL only in severe COPD.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24946786</pmid><doi>10.1186/1471-2466-14-102</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Acquisitions & mergers Aged Airway management Alcoholism - epidemiology Analysis Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Chronic obstructive pulmonary disease Clinical medicine Clinical trials Comorbidity Comparative analysis Diabetes Mellitus - epidemiology Drug therapy Family medical history Female Forced Expiratory Volume Gender Health aspects Health Status Hospitals Humans Lung diseases, Obstructive Male Medical research Medicine, Experimental Middle Aged Morbidity Mortality Patients Population Prevalence Public health Pulmonary Disease, Chronic Obstructive - epidemiology Pulmonary Disease, Chronic Obstructive - mortality Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonology Quality of Life Questionnaires Sensitivity and Specificity Severity of Illness Index Statistical analysis Studies Surveys and Questionnaires |
| title | Co-morbidities are the key nominators of the health related quality of life in mild and moderate COPD |
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