TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations

Background: The role of telomerase reverse transcriptase ( TERT ) in gliomagenesis has been recently further strengthened by the frequent occurrence of TERT promoter mutations ( TERT p-mut) in gliomas and evidence that the TERT SNP genetic rs2736100 influences glioma risk. TERTp -mut creates a bindi...

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Veröffentlicht in:	British journal of cancer 2014-11, Vol.111 (10), p.2024-2032
Hauptverfasser:	Labussière, M, Di Stefano, A L, Gleize, V, Boisselier, B, Giry, M, Mangesius, S, Bruno, A, Paterra, R, Marie, Y, Rahimian, A, Finocchiaro, G, Houlston, R S, Hoang-Xuan, K, Idbaih, A, Delattre, J-Y, Mokhtari, K, Sanson, M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/737 692/699/67/1922 692/700/1750 Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Brain Neoplasms - genetics Brain Neoplasms - pathology Cancer Research DNA methylation Drug Resistance Epidemiology Female Follow-Up Studies Genetics and Genomics Glioma - genetics Glioma - mortality Glioma - pathology Humans Isocitrate Dehydrogenase - genetics Male Medical research Medical sciences Melanoma Middle Aged Molecular Medicine Mutation Mutation - genetics Neoplasm Grading Neurology Oncology Polymerase Chain Reaction Polymorphism Polymorphism, Single Nucleotide - genetics Prognosis Promoter Regions, Genetic - genetics Survival Rate Telomerase Telomerase - genetics Transcription factors Tumors Tumors of the nervous system. Phacomatoses Young Adult
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