The PDE4 Inhibitor HT-0712 Improves Hippocampus-Dependent Memory in Aged Mice

Aging is associated with declines in memory and cognitive function. Here, we evaluate the effects of HT-0712 on memory formation and on cAMP response element-binding protein (CREB)-regulated genes in aged mice. HT-0712 enhanced long-term memory formation in normal young mice at brain concentrations...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2014-12, Vol.39 (13), p.2938-2948
Hauptverfasser:	PETERS, Marco, BLETSCH, Matthew, STANLEY, Jennifer, WHEELER, Damian, SCOTT, Roderick, TULLY, Tim
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Aging Aging - drug effects Animals Biological and medical sciences Brain-Derived Neurotrophic Factor - metabolism Cells, Cultured Conditioning (Psychology) - drug effects CREB-Binding Protein - metabolism Early Growth Response Protein 1 - metabolism Embryo, Mammalian Exploratory Behavior - drug effects Fear - psychology Gene expression Gene Expression Regulation - drug effects Hippocampus - physiology Male Maze Learning - drug effects Medical sciences Memory Memory, Long-Term - drug effects Mice Neurons - drug effects Neurons - metabolism Neurosciences Original Phosphodiesterase 4 Inhibitors - pharmacology Piperidones - pharmacology Protein Binding - drug effects Proteins Proto-Oncogene Proteins c-fos - metabolism Rolipram - pharmacology
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