Progression of logopenic variant primary progressive aphasia to apraxia and semantic memory deficits
Due to the nature of neurodegenerative disorders, patients with primary progressive aphasia develop cognitive impairment other than aphasia as the disorder progresses. The progression of logopenic variant primary progressive aphasia (lvPPA), however, has not been well described. In particular, praxi...
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| Veröffentlicht in: | BMC neurology 2013-11, Vol.13 (1), p.158-158, Article 158 |
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| container_title | BMC neurology |
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| creator | Funayama, Michitaka Nakagawa, Yoshitaka Yamaya, Yoko Yoshino, Fumihiro Mimura, Masaru Kato, Motoichiro |
| description | Due to the nature of neurodegenerative disorders, patients with primary progressive aphasia develop cognitive impairment other than aphasia as the disorder progresses. The progression of logopenic variant primary progressive aphasia (lvPPA), however, has not been well described. In particular, praxic disorders and semantic memory deficits have rarely been reported.
We report three patients in the initial stage of lvPPA who subsequently developed apraxia in the middle stage and developed clinically evident semantic memory deficits in the advanced stages.
The present case series suggests that some patients with lvPPA develop an atypical type of dementia with apraxia and semantic memory deficits, suggesting that these cases should be classified as a type of early-onset Alzheimer's disease. |
| doi_str_mv | 10.1186/1471-2377-13-158 |
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We report three patients in the initial stage of lvPPA who subsequently developed apraxia in the middle stage and developed clinically evident semantic memory deficits in the advanced stages.
The present case series suggests that some patients with lvPPA develop an atypical type of dementia with apraxia and semantic memory deficits, suggesting that these cases should be classified as a type of early-onset Alzheimer's disease.</description><identifier>ISSN: 1471-2377</identifier><identifier>EISSN: 1471-2377</identifier><identifier>DOI: 10.1186/1471-2377-13-158</identifier><identifier>PMID: 24176108</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Alzheimer's disease ; Amnesia ; Aphasia ; Aphasia, Primary Progressive - complications ; Aphasia, Primary Progressive - diagnosis ; Aphasia, Primary Progressive - psychology ; Apraxias - complications ; Apraxias - diagnosis ; Apraxias - psychology ; Behavior ; Care and treatment ; Case Report ; Case studies ; Cognitive ability ; Consent ; Dementia ; Development and progression ; Diagnosis ; Disease Progression ; Electroencephalography ; Humans ; Language disorders ; Male ; Medical imaging ; Memory ; Memory Disorders - complications ; Memory Disorders - diagnosis ; Memory Disorders - psychology ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Patients ; Phonetics ; Risk factors</subject><ispartof>BMC neurology, 2013-11, Vol.13 (1), p.158-158, Article 158</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Funayama et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Funayama et al.; licensee BioMed Central Ltd. 2013 Funayama et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-fef1c8f02e282cf20dca8604a55154c2c047a829d8fb688cc7278a8c821ad0693</citedby><cites>FETCH-LOGICAL-c590t-fef1c8f02e282cf20dca8604a55154c2c047a829d8fb688cc7278a8c821ad0693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228422/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228422/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24176108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Funayama, Michitaka</creatorcontrib><creatorcontrib>Nakagawa, Yoshitaka</creatorcontrib><creatorcontrib>Yamaya, Yoko</creatorcontrib><creatorcontrib>Yoshino, Fumihiro</creatorcontrib><creatorcontrib>Mimura, Masaru</creatorcontrib><creatorcontrib>Kato, Motoichiro</creatorcontrib><title>Progression of logopenic variant primary progressive aphasia to apraxia and semantic memory deficits</title><title>BMC neurology</title><addtitle>BMC Neurol</addtitle><description>Due to the nature of neurodegenerative disorders, patients with primary progressive aphasia develop cognitive impairment other than aphasia as the disorder progresses. The progression of logopenic variant primary progressive aphasia (lvPPA), however, has not been well described. In particular, praxic disorders and semantic memory deficits have rarely been reported.
We report three patients in the initial stage of lvPPA who subsequently developed apraxia in the middle stage and developed clinically evident semantic memory deficits in the advanced stages.
The present case series suggests that some patients with lvPPA develop an atypical type of dementia with apraxia and semantic memory deficits, suggesting that these cases should be classified as a type of early-onset Alzheimer's disease.</description><subject>Alzheimer's disease</subject><subject>Amnesia</subject><subject>Aphasia</subject><subject>Aphasia, Primary Progressive - complications</subject><subject>Aphasia, Primary Progressive - diagnosis</subject><subject>Aphasia, Primary Progressive - psychology</subject><subject>Apraxias - complications</subject><subject>Apraxias - diagnosis</subject><subject>Apraxias - psychology</subject><subject>Behavior</subject><subject>Care and treatment</subject><subject>Case Report</subject><subject>Case studies</subject><subject>Cognitive ability</subject><subject>Consent</subject><subject>Dementia</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Disease Progression</subject><subject>Electroencephalography</subject><subject>Humans</subject><subject>Language disorders</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Memory</subject><subject>Memory Disorders - complications</subject><subject>Memory Disorders - diagnosis</subject><subject>Memory Disorders - psychology</subject><subject>Middle Aged</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Phonetics</subject><subject>Risk factors</subject><issn>1471-2377</issn><issn>1471-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNUk1rFTEUDWKxtbp3JQNu3EzNzeRrNkIptgoFu6jrkGaS15SZ5JnMe9R_7x36-mzFhYRwLzfnHHIPh5B3QE8AtPwEXEHLOqVa6FoQ-gU52o9ePukPyeta7ygFpTm8IoeMg5JA9REZrkpeFV9rzKnJoRnzKq99iq7Z2hJtmpt1iZMtv7DugFvf2PWtrdE2c8a22HtsbRqa6idkIHfyU0bK4EN0ca5vyEGwY_Vvd_WY_Dj_cn32tb38fvHt7PSydaKncxt8AKcDZZ5p5gKjg7NaUm6FAMEdc5Qrq1k_6HAjtXZOMaWtdpqBHajsu2Py-UF3vbmZ_OB8mosdzW4Dk200z19SvDWrvDWcMY0XBT7uBEr-ufF1NlOszo-jTT5vqgHeUyV534n_gEougGuqEPrhL-hd3pSETiBKUCpxXf0HtbKjNzGFjF90i6g5FR2XwGS3rHjyDxSewU_R5YSO4_wZgT4QXMm1Fh_2dgA1S4jMkhKzpMRAZzBESHn_1MY94TE13W_E1cHb</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Funayama, Michitaka</creator><creator>Nakagawa, Yoshitaka</creator><creator>Yamaya, Yoko</creator><creator>Yoshino, Fumihiro</creator><creator>Mimura, Masaru</creator><creator>Kato, Motoichiro</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131101</creationdate><title>Progression of logopenic variant primary progressive aphasia to apraxia and semantic memory deficits</title><author>Funayama, Michitaka ; Nakagawa, Yoshitaka ; Yamaya, Yoko ; Yoshino, Fumihiro ; Mimura, Masaru ; Kato, Motoichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c590t-fef1c8f02e282cf20dca8604a55154c2c047a829d8fb688cc7278a8c821ad0693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alzheimer's disease</topic><topic>Amnesia</topic><topic>Aphasia</topic><topic>Aphasia, Primary Progressive - complications</topic><topic>Aphasia, Primary Progressive - diagnosis</topic><topic>Aphasia, Primary Progressive - psychology</topic><topic>Apraxias - complications</topic><topic>Apraxias - diagnosis</topic><topic>Apraxias - psychology</topic><topic>Behavior</topic><topic>Care and treatment</topic><topic>Case Report</topic><topic>Case studies</topic><topic>Cognitive ability</topic><topic>Consent</topic><topic>Dementia</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Disease Progression</topic><topic>Electroencephalography</topic><topic>Humans</topic><topic>Language disorders</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Memory</topic><topic>Memory Disorders - complications</topic><topic>Memory Disorders - diagnosis</topic><topic>Memory Disorders - psychology</topic><topic>Middle Aged</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Phonetics</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Funayama, Michitaka</creatorcontrib><creatorcontrib>Nakagawa, Yoshitaka</creatorcontrib><creatorcontrib>Yamaya, Yoko</creatorcontrib><creatorcontrib>Yoshino, Fumihiro</creatorcontrib><creatorcontrib>Mimura, Masaru</creatorcontrib><creatorcontrib>Kato, Motoichiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Funayama, Michitaka</au><au>Nakagawa, Yoshitaka</au><au>Yamaya, Yoko</au><au>Yoshino, Fumihiro</au><au>Mimura, Masaru</au><au>Kato, Motoichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progression of logopenic variant primary progressive aphasia to apraxia and semantic memory deficits</atitle><jtitle>BMC neurology</jtitle><addtitle>BMC Neurol</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>13</volume><issue>1</issue><spage>158</spage><epage>158</epage><pages>158-158</pages><artnum>158</artnum><issn>1471-2377</issn><eissn>1471-2377</eissn><abstract>Due to the nature of neurodegenerative disorders, patients with primary progressive aphasia develop cognitive impairment other than aphasia as the disorder progresses. The progression of logopenic variant primary progressive aphasia (lvPPA), however, has not been well described. In particular, praxic disorders and semantic memory deficits have rarely been reported.
We report three patients in the initial stage of lvPPA who subsequently developed apraxia in the middle stage and developed clinically evident semantic memory deficits in the advanced stages.
The present case series suggests that some patients with lvPPA develop an atypical type of dementia with apraxia and semantic memory deficits, suggesting that these cases should be classified as a type of early-onset Alzheimer's disease.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24176108</pmid><doi>10.1186/1471-2377-13-158</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alzheimer's disease Amnesia Aphasia Aphasia, Primary Progressive - complications Aphasia, Primary Progressive - diagnosis Aphasia, Primary Progressive - psychology Apraxias - complications Apraxias - diagnosis Apraxias - psychology Behavior Care and treatment Case Report Case studies Cognitive ability Consent Dementia Development and progression Diagnosis Disease Progression Electroencephalography Humans Language disorders Male Medical imaging Memory Memory Disorders - complications Memory Disorders - diagnosis Memory Disorders - psychology Middle Aged NMR Nuclear magnetic resonance Patients Phonetics Risk factors |
| title | Progression of logopenic variant primary progressive aphasia to apraxia and semantic memory deficits |
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