RhoA and Membrane Fluidity Mediates the Spatially Polarized Src/FAK Activation in Response to Shear Stress

While Src plays crucial roles in shear stress-induced cellular processes, little is known on the spatiotemporal pattern of high shear stress (HSS)-induced Src activation. HSS (65 dyn/cm 2 ) was applied on bovine aortic endothelial cells to visualize the dynamic Src activation at subcellular levels u...

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Veröffentlicht in:	Scientific reports 2014-11, Vol.4 (1), p.7008-7008, Article 7008
Hauptverfasser:	Liu, Bo, Lu, Shaoying, Hu, Ying-li, Liao, Xiaoling, Ouyang, Mingxing, Wang, Yingxiao
Format:	Artikel
Sprache:	eng
Schlagworte:	13/95 14/33 14/35 38/35 631/57/2267 631/80/85/2362 631/80/86/2366 692/699/75/593/2100 9/10 96/33 96/95 Actin Actin Cytoskeleton - drug effects Actin Cytoskeleton - genetics Actin Cytoskeleton - metabolism Actin Cytoskeleton - ultrastructure Animals Aorta Aorta - cytology Aorta - drug effects Aorta - metabolism Benzyl alcohol Benzyl Alcohol - pharmacology Biosensors Cattle Cell Membrane - chemistry Cell Membrane - drug effects Cell Polarity - drug effects Cells, Cultured Cytochalasin D Cytochalasin D - pharmacology Endothelial cells Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Energy transfer Filaments Fluidity Fluorescence Resonance Energy Transfer Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors Focal Adhesion Protein-Tyrosine Kinases - genetics Focal Adhesion Protein-Tyrosine Kinases - metabolism Gene Expression Regulation Humanities and Social Sciences K-Ras protein Mechanical stimuli Mechanotransduction, Cellular Membrane fluidity Membrane Fluidity - drug effects Membranes multidisciplinary Mutation Polarity Protein Kinase Inhibitors - pharmacology Pyrazoles - pharmacology Pyrimidines - pharmacology ras Proteins - genetics ras Proteins - metabolism rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism RhoA protein Science Shear stress Spatial distribution Src protein src-Family Kinases - genetics src-Family Kinases - metabolism Stress, Mechanical
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