Use of a Simplified Nomogram to Individualize Digoxin Dosing versus Standard Dosing Practices in Patients with Heart Failure

Study Objectives To compare the frequency of achieving a therapeutic serum digoxin concentration (SDC), defined as 0.5–0.9 ng/ml, by using a simplified nomogram to individualize digoxin dosing with standard dosing practices in patients with heart failure, and to characterize the relationship between...

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Veröffentlicht in:	Pharmacotherapy 2014-11, Vol.34 (11), p.1121-1131
Hauptverfasser:	DiDomenico, Robert J., Bress, Adam P., Na-Thalang, Kwanta, Tsao, Yvonne Y., Groo, Vicki L., Deyo, Kelly L., Patel, Shitalben R., Bishop, Jeffrey R., Bauman, Jerry L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Academic Medical Centers Aged Amino Acid Substitution ATP Binding Cassette Transporter, Sub-Family B - genetics Biological and medical sciences Cardiology. Vascular system Cardiotonic Agents - administration & dosage Cardiotonic Agents - blood Cardiotonic Agents - pharmacokinetics Cardiotonic Agents - therapeutic use Chicago digoxin Digoxin - administration & dosage Digoxin - blood Digoxin - pharmacokinetics Digoxin - therapeutic use Dose-Response Relationship, Drug dosing nomogram Drug Monitoring Female Gene Frequency Genetic Association Studies Heart heart failure Heart Failure - etiology Heart Failure - prevention & control Heart failure, cardiogenic pulmonary edema, cardiac enlargement Historically Controlled Study Humans Male Medical sciences Middle Aged Nomograms Outpatient Clinics, Hospital Pharmacology. Drug treatments Polymorphism, Single Nucleotide Precision Medicine Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - drug therapy Ventricular Dysfunction, Left - genetics Ventricular Dysfunction, Left - physiopathology
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