Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers

The transcription activator-like effectors (TALEs) and the RNA-guided clustered regularly interspaced short palindromic repeat (CRISPR) associated protein (Cas9) utlilize distinct molecular mechanisms in targeting site recognition. The two proteins can be modified to carry additional functional doma...

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Veröffentlicht in:	Nucleic acids research 2014-11, Vol.42 (20), p.e155-e155
Hauptverfasser:	Gao, Xuefei, Tsang, Jason C H, Gaba, Fortis, Wu, Donghai, Lu, Liming, Liu, Pentao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Cells, Cultured Cellular Reprogramming CRISPR-Associated Proteins - metabolism Enhancer Elements, Genetic Epigenesis, Genetic Gene Expression Regulation Gene Library Genetic Vectors Induced Pluripotent Stem Cells - metabolism Methods Online Mice Octamer Transcription Factor-3 - genetics Plasmids - genetics Repressor Proteins - metabolism Transcription Factors - metabolism Transcriptional Activation
Online-Zugang:	Volltext
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