Tumor Suppression by the Fbw7 Ubiquitin Ligase: Mechanisms and Opportunities

Tumor suppressors with widespread impact on carcinogenesis control broad spectra of oncogenic pathways. Protein degradation is an emerging mechanism by which tumor suppressors regulate a diversity of pathways and is exemplified by the SCFFbw7 ubiquitin ligase. Rapidly accumulating data indicate that...

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Veröffentlicht in:	Cancer cell 2014-10, Vol.26 (4), p.455-464
Hauptverfasser:	Davis, Ryan J., Welcker, Markus, Clurman, Bruce E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - genetics Cell Cycle Proteins - physiology F-Box Proteins - genetics F-Box Proteins - physiology F-Box-WD Repeat-Containing Protein 7 Genes, Tumor Suppressor Humans Mutation Neoplasms - genetics Neoplasms - pathology Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - physiology
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