Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease

Despite evidence about the implication of the bone marrow (BM) stromal microenvironment in multiple myeloma (MM) cell growth and survival, little is known about the effects of myelomatous cells on BM stromal cells. Mesenchymal stromal cells (MSCs) from healthy donors (dMSCs) or myeloma patients (pMS...

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Veröffentlicht in:	Oncotarget 2014-09, Vol.5 (18), p.8284-8305
Hauptverfasser:	Garcia-Gomez, Antonio, De Las Rivas, Javier, Ocio, Enrique M, Díaz-Rodríguez, Elena, Montero, Juan C, Martín, Montserrat, Blanco, Juan F, Sanchez-Guijo, Fermín M, Pandiella, Atanasio, San Miguel, Jesús F, Garayoa, Mercedes
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Diseases - genetics Bone Diseases - metabolism Bone Diseases - pathology Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Cell Communication Cell Line, Tumor Cluster Analysis Coculture Techniques Disease Progression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Gene Regulatory Networks Humans Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - pathology Multiple Myeloma - genetics Multiple Myeloma - metabolism Multiple Myeloma - pathology Research Paper RNA, Messenger - metabolism Signal Transduction Stem Cell Niche Tumor Microenvironment
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