Human CD4+CD39+ regulatory T cells produce adenosine upon co‐expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells

Summary While murine CD4+CD39+ regulatory T cells (Treg) co‐express CD73 and hydrolyze exogenous (e) adenosine triphosphate (ATP) to immunosuppressive adenosine (ADO), surface co‐expression of CD73 on human circulating CD4+CD39+ Treg is rare. Therefore, the ability of human Treg to produce and utili...

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Veröffentlicht in:	Clinical and experimental immunology 2014-08, Vol.177 (2), p.531-543
Hauptverfasser:	Schuler, P. J., Saze, Z., Hong, C.‐S., Muller, L., Gillespie, D. G., Cheng, D., Harasymczuk, M., Mandapathil, M., Lang, S., Jackson, E. K., Whiteside, T. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Nucleotidase - genetics 5'-Nucleotidase - metabolism adenosine Adenosine - biosynthesis Antigens, CD - metabolism Apyrase - metabolism Cell Line Cell Membrane - metabolism Cells, Cultured ectonucleotidases exosomes Exosomes - metabolism Gene Expression human tTreg Humans immune suppression Immune system Immunophenotyping Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lymphocyte Activation Lymphocytes Medical research Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Original Phenotype pTreg T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism
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