Innate immunity drives xenobiotic‐induced murine autoimmune cholangitis

Summary Although primary biliary cirrhosis (PBC) is considered a model autoimmune disease, it has not responded therapeutically to traditional immunosuppressive agents. In addition, PBC may recur following liver transplantation, despite the absence of major histocompatibility complex (MHC) matching,...

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Veröffentlicht in:	Clinical and experimental immunology 2014-08, Vol.177 (2), p.373-380
Hauptverfasser:	Chang, C.‐H., Chen, Y.‐C., Yu, Y.‐H., Tao, M.‐H., Leung, P. S. C., Ansari, A. A., Gershwin, M. E., Chuang, Y.‐H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies - blood Autoantibodies - immunology Autoimmune diseases Autoimmune Diseases - chemically induced Autoimmune Diseases - genetics Autoimmune Diseases - immunology CD4 Antigens - genetics CD4 Antigens - immunology CD4 knock‐out mice CD8 Antigens - genetics CD8 Antigens - immunology CD8 knock‐out mice Cholangitis - chemically induced Cholangitis - genetics Cholangitis - immunology Dihydrolipoyllysine-Residue Acetyltransferase - immunology Disease Models, Animal Fatty Acids, Monounsaturated - adverse effects Fatty Acids, Monounsaturated - immunology Female Galactosylceramides - administration & dosage Galactosylceramides - adverse effects Immunity, Innate Liver - immunology Liver - metabolism Liver - pathology Liver cirrhosis Liver Cirrhosis, Biliary - immunology Mice Mice, Knockout Mitochondrial Proteins - immunology Original primary biliary cirrhosis Serum Albumin, Bovine - adverse effects Serum Albumin, Bovine - immunology Transplants & implants xenobiotics Xenobiotics - adverse effects
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