Dysregulation of Claudin-5 in HIV-induced Interstitial Pneumonitis and Lung Vascular Injury: Protective Role of Peroxisome Proliferator-activated Receptor-γ

HIV-1-induced interstitial pneumonitis (IP) is a serious complication of HIV-1 infection, characterized by inflammation and cellular infiltration in lungs, often leading to respiratory failure and death. The barrier function of the pulmonary endothelium is caused in part by tight junction (TJ) prote...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2014-07, Vol.190 (1), p.85-97
Hauptverfasser:	HONG LI, SINGH, Sangya, POTULA, Raghava, PERSIDSKY, Yuri, KANMOGNE, Georgette D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - complications Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bronchopneumonia - etiology Bronchopneumonia - immunology Bronchopneumonia - microbiology Case-Control Studies Claudin-5 - immunology Claudin-5 - metabolism Disease Models, Animal Down-Regulation - drug effects Down-Regulation - immunology Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Female HIV-1 - immunology HIV-1 - pathogenicity Human viral diseases Humans Immunocompromised Host - immunology Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Intensive care medicine Lung - blood supply Lung - immunology Lung - microbiology Lung Diseases, Interstitial - etiology Lung Diseases, Interstitial - immunology Lung Diseases, Interstitial - microbiology Macrophages - immunology Male Medical sciences Mice Middle Aged Original Pneumology PPAR gamma - immunology PPAR gamma - metabolism Respiratory system : syndromes and miscellaneous diseases Tight Junction Proteins - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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